Comparison of bone inductive proteins of rat and porcine bone matrix

N. Muthukumaran, T. K. Sampath, A Hari Reddi

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Subcutaneous implantation of demineralized bone matrix in allogenic rats induces a sequence of events resulting in de novo formation of cartilage, bone and bone marrow. In the present study endochondral bone formation by demineralized porcine matrix was studied and compared with the rat bone matrix. Endochondral bone formation was induced by 4M guanidine hydrochloride fraction IV (< 50,000 daltons) of Sepharose CL-6B gel filtration but not by whole extract or by demineralized porcine bone matrix. Sephacryl S-200 gel filtration of the osteoinductive proteins of fraction IV showed the Porcine osteoinductive factor to be associated with protein fraction III (< 20,000 daltons) whereas the rat with fraction II (between 20,000 and 30,000 daltons) of the chromatographic profile indicating an apparent difference in molecular weight of the osteoinductive factors between these two species.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Aug 30 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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