Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs

A. Nam, S. M. Kim, J. W. Jeong, K. H. Song, T. S. Koo, Kyoung Won Seo

Research output: Contribution to journalArticle

Abstract

This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW). The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg/kg PDS were significantly greater than those in small-breed dogs given 2 mg/kg and in large-breed dogs given 40 mg/m2. The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect. Meanwhile, BSA dosing at 40 mg/m may be suboptimal. These findings confirm important differences between standard PDS dosing schemes in dogs while highlighting the need to further optimize PDS dosing in large-breed dogs.

Original languageEnglish (US)
Pages (from-to)611-613
Number of pages3
JournalPolish Journal of Veterinary Sciences
Volume20
Issue number3
DOIs
StatePublished - Sep 26 2017
Externally publishedYes

Fingerprint

prednisolone
Body Surface Area
dog breeds
Prednisolone
Oral Administration
mouth
surface area
Dogs
Weights and Measures
Body Weight
body weight
pharmacokinetics
Area Under Curve
Pharmacokinetics
dogs
blood

Keywords

  • body surface area
  • body weight-based
  • large-breed dog
  • pharmacokinetics
  • prednisolone

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs. / Nam, A.; Kim, S. M.; Jeong, J. W.; Song, K. H.; Koo, T. S.; Seo, Kyoung Won.

In: Polish Journal of Veterinary Sciences, Vol. 20, No. 3, 26.09.2017, p. 611-613.

Research output: Contribution to journalArticle

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