Abstract
This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW). The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg/kg PDS were significantly greater than those in small-breed dogs given 2 mg/kg and in large-breed dogs given 40 mg/m2. The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect. Meanwhile, BSA dosing at 40 mg/m may be suboptimal. These findings confirm important differences between standard PDS dosing schemes in dogs while highlighting the need to further optimize PDS dosing in large-breed dogs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 611-613 |
| Number of pages | 3 |
| Journal | Polish Journal of Veterinary Sciences |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 26 2017 |
| Externally published | Yes |
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Keywords
- body surface area
- body weight-based
- large-breed dog
- pharmacokinetics
- prednisolone
ASJC Scopus subject areas
- veterinary(all)
Cite this
Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs. / Nam, A.; Kim, S. M.; Jeong, J. W.; Song, K. H.; Koo, T. S.; Seo, Kyoung Won.
In: Polish Journal of Veterinary Sciences, Vol. 20, No. 3, 26.09.2017, p. 611-613.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs
AU - Nam, A.
AU - Kim, S. M.
AU - Jeong, J. W.
AU - Song, K. H.
AU - Koo, T. S.
AU - Seo, Kyoung Won
PY - 2017/9/26
Y1 - 2017/9/26
N2 - This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW). The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg/kg PDS were significantly greater than those in small-breed dogs given 2 mg/kg and in large-breed dogs given 40 mg/m2. The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect. Meanwhile, BSA dosing at 40 mg/m may be suboptimal. These findings confirm important differences between standard PDS dosing schemes in dogs while highlighting the need to further optimize PDS dosing in large-breed dogs.
AB - This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW). The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg/kg PDS were significantly greater than those in small-breed dogs given 2 mg/kg and in large-breed dogs given 40 mg/m2. The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect. Meanwhile, BSA dosing at 40 mg/m may be suboptimal. These findings confirm important differences between standard PDS dosing schemes in dogs while highlighting the need to further optimize PDS dosing in large-breed dogs.
KW - body surface area
KW - body weight-based
KW - large-breed dog
KW - pharmacokinetics
KW - prednisolone
UR - http://www.scopus.com/inward/record.url?scp=85035353171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85035353171&partnerID=8YFLogxK
U2 - 10.1515/pjvs-2017-0076
DO - 10.1515/pjvs-2017-0076
M3 - Article
C2 - 29166276
AN - SCOPUS:85035353171
VL - 20
SP - 611
EP - 613
JO - Polish Journal of Veterinary Sciences
JF - Polish Journal of Veterinary Sciences
SN - 1505-1773
IS - 3
ER -