Abstract
This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW). The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg/kg PDS were significantly greater than those in small-breed dogs given 2 mg/kg and in large-breed dogs given 40 mg/m2. The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect. Meanwhile, BSA dosing at 40 mg/m may be suboptimal. These findings confirm important differences between standard PDS dosing schemes in dogs while highlighting the need to further optimize PDS dosing in large-breed dogs.
Original language | English (US) |
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Pages (from-to) | 611-613 |
Number of pages | 3 |
Journal | Polish Journal of Veterinary Sciences |
Volume | 20 |
Issue number | 3 |
DOIs | |
State | Published - Sep 26 2017 |
Externally published | Yes |
Keywords
- body surface area
- body weight-based
- large-breed dog
- pharmacokinetics
- prednisolone
ASJC Scopus subject areas
- veterinary(all)