Comparison of body surface area-based and weight-based dosing format for oral prednisolone administration in small and large-breed dogs

A. Nam, S. M. Kim, J. W. Jeong, K. H. Song, T. S. Koo, Kyoung Won Seo

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW). The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg/kg PDS were significantly greater than those in small-breed dogs given 2 mg/kg and in large-breed dogs given 40 mg/m2. The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect. Meanwhile, BSA dosing at 40 mg/m may be suboptimal. These findings confirm important differences between standard PDS dosing schemes in dogs while highlighting the need to further optimize PDS dosing in large-breed dogs.

Original languageEnglish (US)
Pages (from-to)611-613
Number of pages3
JournalPolish Journal of Veterinary Sciences
Volume20
Issue number3
DOIs
StatePublished - Sep 26 2017
Externally publishedYes

Keywords

  • body surface area
  • body weight-based
  • large-breed dog
  • pharmacokinetics
  • prednisolone

ASJC Scopus subject areas

  • veterinary(all)

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