Comparison of an acellular pertussis-component diphtheria-tetanus-pertussis (DTP) vaccine with a whole-cell pertussis-component DTP vaccine in 17- to 24-month-old children, with measurement of 69-kilodalton outer membrane protein antibody

Dean A Blumberg, ChrisAnna M. Mink, James D. Cherry, Keith S. Reisinger, Mark M. Blatter, Blaise L. Congeni, Cornella L. Dekker, Mason G. Stout, Joseph R. Mezzatesta, Jane V. Scott, Peter D. Christenson

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Healthy 17- to 24-month-old children, previously immunized with three doses of whole-cell diphtheria-tetanus-pertussis (DTP) vaccine, were enrolled in a multicenter double-blind, randomized study comparing a DTP vaccine with an acellular pertussis-component (APDT) and a conventional whole-cell pertussis-component DTP vaccine. Thirty-eight children received APDT vaccine, and 37 children received DTP vaccine. APDT vaccine reciplents had significantly less local pain and warmth than DTP vaccine reciplents. Antibody responses to lymphocytosis-promoting factor were similar in the two groups. The APDT vaccine recipients had a higher IgG antibody response to filamentous hemagglutinin than the DTP vaccinees had. Equivalent agglutinin responses were seen in the two groups. The APDT vaccine recipients had a significantly better antibody response to the 69-kilodalton outer membrane protein, as measured by an enzyme-linked immunosorbent assay, than DTP vaccinees had 1 month and 1 year after immunization. This APDT vaccine was immunogenic and caused fewer local reactions than conventional DTP vaccine when administered as a fourth dose to 17- to 24-month-old children.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalThe Journal of Pediatrics
Volume117
Issue number1 PART 1
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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