Comparison of acute and subclinical pelvic inflammatory disease

Harold C. Wiesenfeld, Richard L Sweet, Roberta B. Ness, Marijane A. Krohn, Anthony J. Amortegui, Sharon L. Hillier

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Objective: The objective of this study was to compare the demographic, clinical, and microbiologic findings in women with subclinical pelvic inflammatory disease (PID) and women with acute PID. Study: A cross-sectional study was performed using cohorts from 2 separate studies of 1293 women at risk for PID. Most participants were recruited from emergency departments, sexually transmitted disease clinics, and family planning clinics in metropolitan centers. We compared demographic, clinical, and microbiologic findings among women with acute PID, women with subclinical PID, and women without endometritis (controls). Statistical analyses included chi-square for categorical variables, calculation of odds ratio and 95% confidence intervals, and polychotomous logistic regression when appropriate. Results: Similar proportions of women with acute and subclinical PID tested positive for cervical Chlamydia trachomatis (odds ratio [OR], 1.1; 95% confidence interval, 0.6-2.0) and had bacterial vaginosis (OR, 0.7; 95% CI, 0.2-1.8). The rate of cervical Neisseria gonorrhoeae infection in women with subclinical PID was intermediate between the rates in women with acute PID and controls (21% vs. 49% vs. 7%, respectively, P <0.001, test for trend). Endometrial recovery of N. gonorrhoeae and C. trachomatis in women with subclinical PID was also seen at intermediate levels. Similar distributions of teenagers, women who smoked or used illicit drugs, and women engaging in sexual intercourse during menses were found in each group. Proportions of women with subclinical PID who were black and with lower education levels were intermediate between the proportions of these characteristics in women with acute PID and controls. Conclusion: Demographic and microbiologic characteristics of women with subclinical and acute PID are comparable. These findings suggest that the pathophysiological mechanisms of acute and subclinical PID are similar.

Original languageEnglish (US)
Pages (from-to)400-405
Number of pages6
JournalSexually Transmitted Diseases
Volume32
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

Fingerprint

Pelvic Inflammatory Disease
Neisseria gonorrhoeae
Chlamydia trachomatis
Odds Ratio
Demography
Confidence Intervals
Bacterial Vaginosis
Endometritis
Menstruation
Coitus
Family Planning Services
Street Drugs
Sexually Transmitted Diseases

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)

Cite this

Wiesenfeld, H. C., Sweet, R. L., Ness, R. B., Krohn, M. A., Amortegui, A. J., & Hillier, S. L. (2005). Comparison of acute and subclinical pelvic inflammatory disease. Sexually Transmitted Diseases, 32(7), 400-405. https://doi.org/10.1097/01.olq.0000154508.26532.6a

Comparison of acute and subclinical pelvic inflammatory disease. / Wiesenfeld, Harold C.; Sweet, Richard L; Ness, Roberta B.; Krohn, Marijane A.; Amortegui, Anthony J.; Hillier, Sharon L.

In: Sexually Transmitted Diseases, Vol. 32, No. 7, 07.2005, p. 400-405.

Research output: Contribution to journalArticle

Wiesenfeld, HC, Sweet, RL, Ness, RB, Krohn, MA, Amortegui, AJ & Hillier, SL 2005, 'Comparison of acute and subclinical pelvic inflammatory disease', Sexually Transmitted Diseases, vol. 32, no. 7, pp. 400-405. https://doi.org/10.1097/01.olq.0000154508.26532.6a
Wiesenfeld, Harold C. ; Sweet, Richard L ; Ness, Roberta B. ; Krohn, Marijane A. ; Amortegui, Anthony J. ; Hillier, Sharon L. / Comparison of acute and subclinical pelvic inflammatory disease. In: Sexually Transmitted Diseases. 2005 ; Vol. 32, No. 7. pp. 400-405.
@article{1de39e8c2a8840c28ced468faaa7a145,
title = "Comparison of acute and subclinical pelvic inflammatory disease",
abstract = "Objective: The objective of this study was to compare the demographic, clinical, and microbiologic findings in women with subclinical pelvic inflammatory disease (PID) and women with acute PID. Study: A cross-sectional study was performed using cohorts from 2 separate studies of 1293 women at risk for PID. Most participants were recruited from emergency departments, sexually transmitted disease clinics, and family planning clinics in metropolitan centers. We compared demographic, clinical, and microbiologic findings among women with acute PID, women with subclinical PID, and women without endometritis (controls). Statistical analyses included chi-square for categorical variables, calculation of odds ratio and 95{\%} confidence intervals, and polychotomous logistic regression when appropriate. Results: Similar proportions of women with acute and subclinical PID tested positive for cervical Chlamydia trachomatis (odds ratio [OR], 1.1; 95{\%} confidence interval, 0.6-2.0) and had bacterial vaginosis (OR, 0.7; 95{\%} CI, 0.2-1.8). The rate of cervical Neisseria gonorrhoeae infection in women with subclinical PID was intermediate between the rates in women with acute PID and controls (21{\%} vs. 49{\%} vs. 7{\%}, respectively, P <0.001, test for trend). Endometrial recovery of N. gonorrhoeae and C. trachomatis in women with subclinical PID was also seen at intermediate levels. Similar distributions of teenagers, women who smoked or used illicit drugs, and women engaging in sexual intercourse during menses were found in each group. Proportions of women with subclinical PID who were black and with lower education levels were intermediate between the proportions of these characteristics in women with acute PID and controls. Conclusion: Demographic and microbiologic characteristics of women with subclinical and acute PID are comparable. These findings suggest that the pathophysiological mechanisms of acute and subclinical PID are similar.",
author = "Wiesenfeld, {Harold C.} and Sweet, {Richard L} and Ness, {Roberta B.} and Krohn, {Marijane A.} and Amortegui, {Anthony J.} and Hillier, {Sharon L.}",
year = "2005",
month = "7",
doi = "10.1097/01.olq.0000154508.26532.6a",
language = "English (US)",
volume = "32",
pages = "400--405",
journal = "Sexually Transmitted Diseases",
issn = "0148-5717",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Comparison of acute and subclinical pelvic inflammatory disease

AU - Wiesenfeld, Harold C.

AU - Sweet, Richard L

AU - Ness, Roberta B.

AU - Krohn, Marijane A.

AU - Amortegui, Anthony J.

AU - Hillier, Sharon L.

PY - 2005/7

Y1 - 2005/7

N2 - Objective: The objective of this study was to compare the demographic, clinical, and microbiologic findings in women with subclinical pelvic inflammatory disease (PID) and women with acute PID. Study: A cross-sectional study was performed using cohorts from 2 separate studies of 1293 women at risk for PID. Most participants were recruited from emergency departments, sexually transmitted disease clinics, and family planning clinics in metropolitan centers. We compared demographic, clinical, and microbiologic findings among women with acute PID, women with subclinical PID, and women without endometritis (controls). Statistical analyses included chi-square for categorical variables, calculation of odds ratio and 95% confidence intervals, and polychotomous logistic regression when appropriate. Results: Similar proportions of women with acute and subclinical PID tested positive for cervical Chlamydia trachomatis (odds ratio [OR], 1.1; 95% confidence interval, 0.6-2.0) and had bacterial vaginosis (OR, 0.7; 95% CI, 0.2-1.8). The rate of cervical Neisseria gonorrhoeae infection in women with subclinical PID was intermediate between the rates in women with acute PID and controls (21% vs. 49% vs. 7%, respectively, P <0.001, test for trend). Endometrial recovery of N. gonorrhoeae and C. trachomatis in women with subclinical PID was also seen at intermediate levels. Similar distributions of teenagers, women who smoked or used illicit drugs, and women engaging in sexual intercourse during menses were found in each group. Proportions of women with subclinical PID who were black and with lower education levels were intermediate between the proportions of these characteristics in women with acute PID and controls. Conclusion: Demographic and microbiologic characteristics of women with subclinical and acute PID are comparable. These findings suggest that the pathophysiological mechanisms of acute and subclinical PID are similar.

AB - Objective: The objective of this study was to compare the demographic, clinical, and microbiologic findings in women with subclinical pelvic inflammatory disease (PID) and women with acute PID. Study: A cross-sectional study was performed using cohorts from 2 separate studies of 1293 women at risk for PID. Most participants were recruited from emergency departments, sexually transmitted disease clinics, and family planning clinics in metropolitan centers. We compared demographic, clinical, and microbiologic findings among women with acute PID, women with subclinical PID, and women without endometritis (controls). Statistical analyses included chi-square for categorical variables, calculation of odds ratio and 95% confidence intervals, and polychotomous logistic regression when appropriate. Results: Similar proportions of women with acute and subclinical PID tested positive for cervical Chlamydia trachomatis (odds ratio [OR], 1.1; 95% confidence interval, 0.6-2.0) and had bacterial vaginosis (OR, 0.7; 95% CI, 0.2-1.8). The rate of cervical Neisseria gonorrhoeae infection in women with subclinical PID was intermediate between the rates in women with acute PID and controls (21% vs. 49% vs. 7%, respectively, P <0.001, test for trend). Endometrial recovery of N. gonorrhoeae and C. trachomatis in women with subclinical PID was also seen at intermediate levels. Similar distributions of teenagers, women who smoked or used illicit drugs, and women engaging in sexual intercourse during menses were found in each group. Proportions of women with subclinical PID who were black and with lower education levels were intermediate between the proportions of these characteristics in women with acute PID and controls. Conclusion: Demographic and microbiologic characteristics of women with subclinical and acute PID are comparable. These findings suggest that the pathophysiological mechanisms of acute and subclinical PID are similar.

UR - http://www.scopus.com/inward/record.url?scp=21044435524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21044435524&partnerID=8YFLogxK

U2 - 10.1097/01.olq.0000154508.26532.6a

DO - 10.1097/01.olq.0000154508.26532.6a

M3 - Article

C2 - 15976596

AN - SCOPUS:21044435524

VL - 32

SP - 400

EP - 405

JO - Sexually Transmitted Diseases

JF - Sexually Transmitted Diseases

SN - 0148-5717

IS - 7

ER -