Comparison of acellular and whole-cell pertussis-component diphtheria-tetanus-pertussis vaccines in infants

Dean A Blumberg, ChrisAnna M. Mink, James D. Cherry, Candice Johnson, Rachel Garber, Stanley A. Plotkin, Barbara Watson, Gerard A. Ballanco, Robert S. Daum, Bradley Sullivan, Timothy R. Townsend, James Brayton, W. M. Gooch, David B. Nelson, Blaise L. Congeni, Charles G. Prober, Jill G. Hackell, Cornelia L. Dekker, Peter D. Christenson

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

In a multicenter, double-blind, randomized, longitudinal study, 252 children recelved licensed Lederie diphtheria-tetanus toxoids and pertussis vaccine adsorbed (DTP) at 2, 4, and 6 months of age, and 245 children received a DTP vaccine with the Lederle/Takeda acellular pertussis component (APDT) at the same ages. Both groups of children received APDT vaccine at 18 months of age. After each of the first three immunizations, APDT vaccine recipients had fewer local and systemic reactions than did DTP vaccinees. Reactions after the 18-months APDT vaccination were minimal in severity regardiess of the vaccine previously received. Antibody responses to lymphocytosis-promoting factor and agglutinogens were more pronounced in DTP recipients; however, APDT recipients had a better serologic response to filamentous hemagglutinin, and responses to the 69K protein were equivalent. This APDT vaccine produces fewer reactions than the standard whole-cell DTP vaccine. The protective significance of the serologic responses to the APDT vaccine is unknown, but the greater response to filamentous hemagglutinin and equivalent response to the 69K protein compared with those to DTP vaccine seem promising.

Original languageEnglish (US)
Pages (from-to)194-204
Number of pages11
JournalThe Journal of Pediatrics
Volume119
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

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Diphtheria-Tetanus-Pertussis Vaccine
Whooping Cough
Cellular Structures
Vaccines
Hemagglutinins
Diphtheria Toxoid
Tetanus Toxoid
Pertussis Toxin
Antibody Formation
Longitudinal Studies
Immunization
Vaccination
Proteins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Comparison of acellular and whole-cell pertussis-component diphtheria-tetanus-pertussis vaccines in infants. / Blumberg, Dean A; Mink, ChrisAnna M.; Cherry, James D.; Johnson, Candice; Garber, Rachel; Plotkin, Stanley A.; Watson, Barbara; Ballanco, Gerard A.; Daum, Robert S.; Sullivan, Bradley; Townsend, Timothy R.; Brayton, James; Gooch, W. M.; Nelson, David B.; Congeni, Blaise L.; Prober, Charles G.; Hackell, Jill G.; Dekker, Cornelia L.; Christenson, Peter D.

In: The Journal of Pediatrics, Vol. 119, No. 2, 1991, p. 194-204.

Research output: Contribution to journalArticle

Blumberg, DA, Mink, CM, Cherry, JD, Johnson, C, Garber, R, Plotkin, SA, Watson, B, Ballanco, GA, Daum, RS, Sullivan, B, Townsend, TR, Brayton, J, Gooch, WM, Nelson, DB, Congeni, BL, Prober, CG, Hackell, JG, Dekker, CL & Christenson, PD 1991, 'Comparison of acellular and whole-cell pertussis-component diphtheria-tetanus-pertussis vaccines in infants', The Journal of Pediatrics, vol. 119, no. 2, pp. 194-204. https://doi.org/10.1016/S0022-3476(05)80727-9
Blumberg, Dean A ; Mink, ChrisAnna M. ; Cherry, James D. ; Johnson, Candice ; Garber, Rachel ; Plotkin, Stanley A. ; Watson, Barbara ; Ballanco, Gerard A. ; Daum, Robert S. ; Sullivan, Bradley ; Townsend, Timothy R. ; Brayton, James ; Gooch, W. M. ; Nelson, David B. ; Congeni, Blaise L. ; Prober, Charles G. ; Hackell, Jill G. ; Dekker, Cornelia L. ; Christenson, Peter D. / Comparison of acellular and whole-cell pertussis-component diphtheria-tetanus-pertussis vaccines in infants. In: The Journal of Pediatrics. 1991 ; Vol. 119, No. 2. pp. 194-204.
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