Comparison between the scintigraphic uptake and plasma clearance of 99MTc-diethylenetriaminepentacetic acid (DTPA) for the evaluation of the glomerular filtration rate in dogs

Paul Y. Barthez, William J. Hornof, Larry D Cowgill, Larry A. Neal, Paul Mickel

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The scintigraphically measured percentage dose uptake of 99mTc-DTPA by the kidneys and the plasma clearance of 99mTc-DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance. Correlation between inulin clearance and the 99mTc-DTPA plasma clearance was better (p = .0016) than the correlation between the percentage DTPA uptake by the kidney. It was concluded that measurement of 99mTc-DTPA plasma clearance is a more accurate method to estimate global glomerular filtration rate (GFR) than the percentage kidney uptake.

Original languageEnglish (US)
Pages (from-to)470-474
Number of pages5
JournalVeterinary Radiology and Ultrasound
Volume39
Issue number5
StatePublished - Sep 1998

Keywords

  • Tc-DTPA
  • Dog
  • GFR
  • Scintigraphy

ASJC Scopus subject areas

  • veterinary(all)

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