Comparison between 1-needle technique versus 2-needle technique for bone marrow aspiration and biopsy procedures

Alyaa Al-Ibraheemi, Tiffany Pham, Lei Chen, Erica Syklawer, Andres Quesada, Amer Wahed, Elena Nedelcu, Andy N D Nguyen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Context. - Bone marrow examination is essential for diagnosis and staging of hematologic disorders. Traditionally, the bone marrow biopsy and aspirate are obtained with 2 needles at 2 separate sites. This approach is associated with significant discomfort, procedural time, and occasionally, morbidity. Although previous observations had suggested that a single-needle technique at one site is a simpler and less-painful procedure, there had been concern that the 1-needle technique may yield a suboptimal biopsy for diagnosis. Objective. - To conduct a systematic comparison of multiple parameters of bone marrow biopsy specimens obtained by the traditional 2-needle technique versus the 1-needle technique for bone marrow collection. Design. - We retrospectively evaluated 20 biopsy specimens obtained by each of the 2 mentioned techniques by comparing the morphologic quality of the biopsy, biopsy length, and biopsy cellularity. Results. - We found that the 1-needle technique yielded an adequate biopsy for diagnosis. The measured parameters of the samples obtained by the 1-needle versus 2-needle techniques were similar. Conclusion. - This study suggests that the 1-needle technique may be preferred for bone marrow aspirate and biopsy.

Original languageEnglish (US)
Pages (from-to)974-978
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Issue number7
StatePublished - Jul 2013
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


Dive into the research topics of 'Comparison between 1-needle technique versus 2-needle technique for bone marrow aspiration and biopsy procedures'. Together they form a unique fingerprint.

Cite this