Comparative vaccine-specific and other injectable-specific risks of injection-site sarcomas in cats.

Anup Srivastav, Philip H. Kass, Lawrence D. McGill, Thomas B. Farver, Michael S. Kent

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23 Citations (Scopus)

Abstract

To compare associations between vaccine types and other injectable drugs with development of injection-site sarcomas in cats. Case-control study. 181 cats with soft tissue sarcomas (cases), 96 cats with tumors at non-vaccine regions (control group I), and 159 cats with basal cell tumors (control group II). Subjects were prospectively obtained from a large pathology database. Demographic, sarcoma location, basal cell tumor, and vaccine and other injectable history data were documented by use of a questionnaire and used to define case, control, and exposure status. Three control groups were included: cats with sarcomas at non-vaccine sites, cats with basal cell tumors, and a combined group of cats with sarcomas at non-vaccine sites and cats with basal cell tumors. χ(2) tests, marginal homogeneity tests, and exact logistic regression were performed. In the broad interscapular region, the frequency of administration of long-acting corticosteroid injections (dexamethasone, methylprednisolone, and triamcinolone) was significantly higher in cases than in controls. In the broad rear limb region, case cats were significantly less likely to have received recombinant vaccines than inactivated vaccines; ORs from logistic regression analyses equaled 0.1, with 95% confidence intervals ranging from 0 to 0.4 and 0 to 0.7, depending on control group and time period of exposure used. This case-control study measuring temporal and spatial exposures efficiently detected associations between administrations of various types of vaccines (recombinant vs inactivated rabies) and other injectable products (ie, long-acting corticosteroids) with sarcoma development without the need to directly measure incidence. These findings nevertheless also indicated that no vaccines were risk free. The study is informative in allowing practitioners to weigh the relative merits and risks of commonly used pharmaceutical products.

Original languageEnglish (US)
Pages (from-to)595-602
Number of pages8
JournalJournal of the American Veterinary Medical Association
Volume241
Issue number5
StatePublished - Sep 1 2012

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injection site
sarcoma
Sarcoma
Cats
Vaccines
cats
vaccines
Injections
neoplasms
Control Groups
Synthetic Vaccines
recombinant vaccines
adrenal cortex hormones
case-control studies
Case-Control Studies
Neoplasms
Adrenal Cortex Hormones
Logistic Models
triamcinolone
cells

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Comparative vaccine-specific and other injectable-specific risks of injection-site sarcomas in cats.",
abstract = "To compare associations between vaccine types and other injectable drugs with development of injection-site sarcomas in cats. Case-control study. 181 cats with soft tissue sarcomas (cases), 96 cats with tumors at non-vaccine regions (control group I), and 159 cats with basal cell tumors (control group II). Subjects were prospectively obtained from a large pathology database. Demographic, sarcoma location, basal cell tumor, and vaccine and other injectable history data were documented by use of a questionnaire and used to define case, control, and exposure status. Three control groups were included: cats with sarcomas at non-vaccine sites, cats with basal cell tumors, and a combined group of cats with sarcomas at non-vaccine sites and cats with basal cell tumors. χ(2) tests, marginal homogeneity tests, and exact logistic regression were performed. In the broad interscapular region, the frequency of administration of long-acting corticosteroid injections (dexamethasone, methylprednisolone, and triamcinolone) was significantly higher in cases than in controls. In the broad rear limb region, case cats were significantly less likely to have received recombinant vaccines than inactivated vaccines; ORs from logistic regression analyses equaled 0.1, with 95{\%} confidence intervals ranging from 0 to 0.4 and 0 to 0.7, depending on control group and time period of exposure used. This case-control study measuring temporal and spatial exposures efficiently detected associations between administrations of various types of vaccines (recombinant vs inactivated rabies) and other injectable products (ie, long-acting corticosteroids) with sarcoma development without the need to directly measure incidence. These findings nevertheless also indicated that no vaccines were risk free. The study is informative in allowing practitioners to weigh the relative merits and risks of commonly used pharmaceutical products.",
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AU - Farver, Thomas B.

AU - Kent, Michael S.

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