Comparative treatment of mares susceptible to chronic uterine infection.

M. H. Troedsson, M. A. Scott, Irwin Liu

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Abstract

Four intrauterine treatment strategies were evaluated for effectiveness in mares that were confirmed to be susceptible to chronic uterine infection. Pretreatment samples were obtained at detection of estrus, and a genital strain of Streptococcus zooepidemicus was infused into the uterus when a preovulatory (> 35 mm) follicle was detected. At 12 hours after inoculation, mares were assigned to 1 of 4 selected treatment groups: autologous plasma, 100 ml (n = 5); potassium penicillin, 5 million U in 100 ml of phosphate-buffered saline solution (PBSS; n = 5); 10 mg of prostaglandin F2 alpha in 100 ml of PBSS (n = 5)' and large-volume lavage with normal saline solution (1,000 ml increments). A fifth group, treated with vehicle alone (100 ml of PBSS), served as a negative control (n = 7). All treatments were administered into the uterus. To assess the effectiveness of the treatment, samples for culture and cytologic examination were collected at 96 hours after bacterial inoculation. An effect of treatment was observed on the number of uterine neutrophils (P = 0.02) and growth of S zooepidemicus (P < 0.01). Intrauterine treatment with potassium penicillin, prostaglandin F2 alpha, and large-volume uterine lavage significantly reduced the growth of S zooepidemicus (P < 0.01) as well as the number of neutrophils (P < 0.02). Autologous plasma reduced the number of neutrophils (P < 0.05), but not growth of S zooepidemicus. There was significant correlation between the number of uterine neutrophils and growth of S zooepidemicus for each treatment group (r = 0.57; P < 0.05).

Original languageEnglish (US)
Pages (from-to)468-472
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume56
Issue number4
StatePublished - Apr 1 1995

Fingerprint

mares
neutrophils
Neutrophils
penicillins
Infection
infection
sodium chloride
uterus
prostaglandins
Dinoprost
Therapeutic Irrigation
potassium
Streptococcus equi subsp. zooepidemicus
Growth
Sodium Chloride
Penicillins
Uterus
estrus detection
Potassium
Therapeutics

ASJC Scopus subject areas

  • veterinary(all)

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Comparative treatment of mares susceptible to chronic uterine infection. / Troedsson, M. H.; Scott, M. A.; Liu, Irwin.

In: American Journal of Veterinary Research, Vol. 56, No. 4, 01.04.1995, p. 468-472.

Research output: Contribution to journalArticle

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