Comparative studies of aryl hydrocarbon hydroxylase and the Ah receptor in nonmammalian species

Michael S. Denison, Joshua W. Hamilton, Christopher F. Wilkinson

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

1. In vivo treatment of chicks, quail and rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3-methylcholanthrene (MC) caused a dose-dependent increase in hepatic microsomal aryl hydrocarbon hydroxylase activity. 2. A much lower level of AHH induction was observed following similar treatment of trout with high concentrations of TCDD or MC. 3. No induction was apparent in midgut tissues from southern armyworm larvae exposed to the same inducers. 4. A low level of receptor exhibiting specific binding of [3H]TCDD was demonstrated in chick hepatic cytosol, but no evidence of receptor was obtained with the other species. 5. Although the specific binding of the receptor in chick eytosol was only 6-8 fmoles TCDD bound/mg protein compared to 135 fmoles/mg in rat hepatic cytosol, the chick receptor exhibited properties similar to those of Ah receptors in mammals.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume80
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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