Abstract
1. In vivo treatment of chicks, quail and rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3-methylcholanthrene (MC) caused a dose-dependent increase in hepatic microsomal aryl hydrocarbon hydroxylase activity. 2. A much lower level of AHH induction was observed following similar treatment of trout with high concentrations of TCDD or MC. 3. No induction was apparent in midgut tissues from southern armyworm larvae exposed to the same inducers. 4. A low level of receptor exhibiting specific binding of [3H]TCDD was demonstrated in chick hepatic cytosol, but no evidence of receptor was obtained with the other species. 5. Although the specific binding of the receptor in chick eytosol was only 6-8 fmoles TCDD bound/mg protein compared to 135 fmoles/mg in rat hepatic cytosol, the chick receptor exhibited properties similar to those of Ah receptors in mammals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 319-324 |
| Number of pages | 6 |
| Journal | Comparative Biochemistry and Physiology. Part C, Comparative |
| Volume | 80 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Pharmacology
Cite this
Comparative studies of aryl hydrocarbon hydroxylase and the Ah receptor in nonmammalian species. / Denison, Michael S.; Hamilton, Joshua W.; Wilkinson, Christopher F.
In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 80, No. 2, 1985, p. 319-324.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative studies of aryl hydrocarbon hydroxylase and the Ah receptor in nonmammalian species
AU - Denison, Michael S.
AU - Hamilton, Joshua W.
AU - Wilkinson, Christopher F.
PY - 1985
Y1 - 1985
N2 - 1. In vivo treatment of chicks, quail and rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3-methylcholanthrene (MC) caused a dose-dependent increase in hepatic microsomal aryl hydrocarbon hydroxylase activity. 2. A much lower level of AHH induction was observed following similar treatment of trout with high concentrations of TCDD or MC. 3. No induction was apparent in midgut tissues from southern armyworm larvae exposed to the same inducers. 4. A low level of receptor exhibiting specific binding of [3H]TCDD was demonstrated in chick hepatic cytosol, but no evidence of receptor was obtained with the other species. 5. Although the specific binding of the receptor in chick eytosol was only 6-8 fmoles TCDD bound/mg protein compared to 135 fmoles/mg in rat hepatic cytosol, the chick receptor exhibited properties similar to those of Ah receptors in mammals.
AB - 1. In vivo treatment of chicks, quail and rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3-methylcholanthrene (MC) caused a dose-dependent increase in hepatic microsomal aryl hydrocarbon hydroxylase activity. 2. A much lower level of AHH induction was observed following similar treatment of trout with high concentrations of TCDD or MC. 3. No induction was apparent in midgut tissues from southern armyworm larvae exposed to the same inducers. 4. A low level of receptor exhibiting specific binding of [3H]TCDD was demonstrated in chick hepatic cytosol, but no evidence of receptor was obtained with the other species. 5. Although the specific binding of the receptor in chick eytosol was only 6-8 fmoles TCDD bound/mg protein compared to 135 fmoles/mg in rat hepatic cytosol, the chick receptor exhibited properties similar to those of Ah receptors in mammals.
UR - http://www.scopus.com/inward/record.url?scp=0021909357&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021909357&partnerID=8YFLogxK
U2 - 10.1016/0742-8413(85)90063-5
DO - 10.1016/0742-8413(85)90063-5
M3 - Article
C2 - 2861016
AN - SCOPUS:0021909357
VL - 80
SP - 319
EP - 324
JO - Comparative biochemistry and physiology. C: Comparative pharmacology
JF - Comparative biochemistry and physiology. C: Comparative pharmacology
SN - 0742-8413
IS - 2
ER -