Comparative review of diets for the metabolic syndrome: Implications for nonalcoholic fatty liver disease

Angela M. Zivkovic, J. Bruce German, Arun J. Sanyal

Research output: Contribution to journalArticle

277 Citations (Scopus)

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a significant health problem and affects 70 million adults in the United States(30%of the adult population), and an estimated 20% of these individuals have the most severe form of NAFLD - nonalcoholic steatohepatitis (NASH). The mechanisms underlying disease development and progression are awaiting clarification. Insulin resistance and obesity-related inflammation, among other possible genetic, dietary, and lifestyle factors, are thought to play a key role. A program targeting gradual weight reduction and physical exercise continues to be the gold standard of treatment for all forms of NAFLD. Even though weight loss and dietary and lifestyle changes are recommended as primary treatment for fatty liver, little to no scientific evidence is available on diet and NAFLD. This article reviews the implications of current dietary approaches, including national guidelines and popular weight-loss diets, with a focus on determining the optimal diet to prescribe for NAFLD and NASH patients. The effects of macronutrient content (carbohydrate, fat, and protein ratios) and specific food components, such as soluble fiber, n-3 fatty acids, and fructose, are discussed. The premises, effects, barriers, and issues related to current dietary guidelines and specific diets are discussed, and the question, "Will it work for the pathogenesis of NAFLD and NASH?", is addressed.

Original languageEnglish (US)
Pages (from-to)285-300
Number of pages16
JournalAmerican Journal of Clinical Nutrition
Volume86
Issue number2
StatePublished - Aug 1 2007

Fingerprint

fatty liver
metabolic syndrome
Diet
diet
weight loss
lifestyle
Life Style
Weight Loss
optimal nutrition
Dietary Guidelines
soluble fiber
Reducing Diet
Non-alcoholic Fatty Liver Disease
carbohydrate content
Nutrition Policy
insulin resistance
omega-3 fatty acids
gold
fructose
Omega-3 Fatty Acids

Keywords

  • Diet
  • NAFLD
  • NASH
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Weight loss

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Comparative review of diets for the metabolic syndrome : Implications for nonalcoholic fatty liver disease. / Zivkovic, Angela M.; German, J. Bruce; Sanyal, Arun J.

In: American Journal of Clinical Nutrition, Vol. 86, No. 2, 01.08.2007, p. 285-300.

Research output: Contribution to journalArticle

Zivkovic, Angela M. ; German, J. Bruce ; Sanyal, Arun J. / Comparative review of diets for the metabolic syndrome : Implications for nonalcoholic fatty liver disease. In: American Journal of Clinical Nutrition. 2007 ; Vol. 86, No. 2. pp. 285-300.
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