Comparative operative outcomes of early and delayed cholecystectomy for acute cholecystitis: A population-based propensity score analysis

Charles De Mestral, Ori D. Rotstein, Andreas Laupacis, Jeffrey S Hoch, Brandon Zagorski, Aziz S. Alali, Avery B. Nathens

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To compare the operative outcomes of early and delayed cholecystectomy for acute cholecystitis. BACKGROUND: Randomized trials comparing early to delayed cholecystectomy for acute cholecystitis have limited contemporary external validity. Furthermore, no study to date has been large enough to assess the impact of timing of cholecystectomy on the frequency of serious rare complications including bile duct injury and death. METHODS: This is a population-based retrospective cohort study of patients emergently admitted to hospital with acute cholecystitis and managed with cholecystectomy over the period of April 1, 2004, to March 31, 2011. We used administrative records for the province of Ontario, Canada. Patients were divided into 2 exposure groups: those who underwent cholecystectomy within 7 days of emergency department presentation on index admission (early cholecystectomy) and those whose cholecystectomy was delayed. The primary outcome was major bile duct injury requiring operative repair within 6 months of cholecystectomy. Secondary outcomes included major bile duct injury or death, 30-day postcholecystectomy mortality, completion of cholecystectomy with an open approach, conversion among laparoscopic cases, and total hospital length of stay. Propensity score methods were used to address confounding by indication. RESULTS: From 22,202 patients, a well-balanced matched cohort of 14,220 patients was defined. Early cholecystectomy was associated with a lower risk of major bile duct injury [0.28% vs 0.53%, relative risk (RR) = 0.53, 95% confidence interval [CI]: 0.31-0.90], of major bile duct injury or death (1.36% vs 1.88%, RR = 0.72, 95% CI: 0.56-0.94), and, albeit non-significant, of 30-day mortality (0.46% vs 0.64%, RR = 0.73, 95% CI: 0.47-1.15). Total hospital length of stay was shorter with early cholecystectomy (mean difference 1.9 days, 95% CI: 1.7-2.1). No significant differences were observed in terms, open cholecystectomy (15% vs 14%, RR = 1.07, 95% CI: 0.99-1.16) or in conversion among laparoscopic cases (11% vs 10%, RR = 1.02, 95% CI: 0.93-1.13). CONCLUSIONS: These results support the benefit of early overdelayed cholecystectomy for patients with acute cholecystitis.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalAnnals of Surgery
Volume259
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Fingerprint

Propensity Score
Acute Cholecystitis
Cholecystectomy
Population
Bile Ducts
Confidence Intervals
Length of Stay
Wounds and Injuries
Mortality
Ontario
Canada
Hospital Emergency Service

Keywords

  • Acute cholecystitis
  • Bile duct injury
  • Delayed cholecystectomy
  • Early cholecystectomy
  • Laparoscopic cholecystectomy

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

Comparative operative outcomes of early and delayed cholecystectomy for acute cholecystitis : A population-based propensity score analysis. / De Mestral, Charles; Rotstein, Ori D.; Laupacis, Andreas; Hoch, Jeffrey S; Zagorski, Brandon; Alali, Aziz S.; Nathens, Avery B.

In: Annals of Surgery, Vol. 259, No. 1, 01.2014, p. 10-15.

Research output: Contribution to journalArticle

De Mestral, Charles ; Rotstein, Ori D. ; Laupacis, Andreas ; Hoch, Jeffrey S ; Zagorski, Brandon ; Alali, Aziz S. ; Nathens, Avery B. / Comparative operative outcomes of early and delayed cholecystectomy for acute cholecystitis : A population-based propensity score analysis. In: Annals of Surgery. 2014 ; Vol. 259, No. 1. pp. 10-15.
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abstract = "OBJECTIVE: To compare the operative outcomes of early and delayed cholecystectomy for acute cholecystitis. BACKGROUND: Randomized trials comparing early to delayed cholecystectomy for acute cholecystitis have limited contemporary external validity. Furthermore, no study to date has been large enough to assess the impact of timing of cholecystectomy on the frequency of serious rare complications including bile duct injury and death. METHODS: This is a population-based retrospective cohort study of patients emergently admitted to hospital with acute cholecystitis and managed with cholecystectomy over the period of April 1, 2004, to March 31, 2011. We used administrative records for the province of Ontario, Canada. Patients were divided into 2 exposure groups: those who underwent cholecystectomy within 7 days of emergency department presentation on index admission (early cholecystectomy) and those whose cholecystectomy was delayed. The primary outcome was major bile duct injury requiring operative repair within 6 months of cholecystectomy. Secondary outcomes included major bile duct injury or death, 30-day postcholecystectomy mortality, completion of cholecystectomy with an open approach, conversion among laparoscopic cases, and total hospital length of stay. Propensity score methods were used to address confounding by indication. RESULTS: From 22,202 patients, a well-balanced matched cohort of 14,220 patients was defined. Early cholecystectomy was associated with a lower risk of major bile duct injury [0.28{\%} vs 0.53{\%}, relative risk (RR) = 0.53, 95{\%} confidence interval [CI]: 0.31-0.90], of major bile duct injury or death (1.36{\%} vs 1.88{\%}, RR = 0.72, 95{\%} CI: 0.56-0.94), and, albeit non-significant, of 30-day mortality (0.46{\%} vs 0.64{\%}, RR = 0.73, 95{\%} CI: 0.47-1.15). Total hospital length of stay was shorter with early cholecystectomy (mean difference 1.9 days, 95{\%} CI: 1.7-2.1). No significant differences were observed in terms, open cholecystectomy (15{\%} vs 14{\%}, RR = 1.07, 95{\%} CI: 0.99-1.16) or in conversion among laparoscopic cases (11{\%} vs 10{\%}, RR = 1.02, 95{\%} CI: 0.93-1.13). CONCLUSIONS: These results support the benefit of early overdelayed cholecystectomy for patients with acute cholecystitis.",
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T1 - Comparative operative outcomes of early and delayed cholecystectomy for acute cholecystitis

T2 - A population-based propensity score analysis

AU - De Mestral, Charles

AU - Rotstein, Ori D.

AU - Laupacis, Andreas

AU - Hoch, Jeffrey S

AU - Zagorski, Brandon

AU - Alali, Aziz S.

AU - Nathens, Avery B.

PY - 2014/1

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N2 - OBJECTIVE: To compare the operative outcomes of early and delayed cholecystectomy for acute cholecystitis. BACKGROUND: Randomized trials comparing early to delayed cholecystectomy for acute cholecystitis have limited contemporary external validity. Furthermore, no study to date has been large enough to assess the impact of timing of cholecystectomy on the frequency of serious rare complications including bile duct injury and death. METHODS: This is a population-based retrospective cohort study of patients emergently admitted to hospital with acute cholecystitis and managed with cholecystectomy over the period of April 1, 2004, to March 31, 2011. We used administrative records for the province of Ontario, Canada. Patients were divided into 2 exposure groups: those who underwent cholecystectomy within 7 days of emergency department presentation on index admission (early cholecystectomy) and those whose cholecystectomy was delayed. The primary outcome was major bile duct injury requiring operative repair within 6 months of cholecystectomy. Secondary outcomes included major bile duct injury or death, 30-day postcholecystectomy mortality, completion of cholecystectomy with an open approach, conversion among laparoscopic cases, and total hospital length of stay. Propensity score methods were used to address confounding by indication. RESULTS: From 22,202 patients, a well-balanced matched cohort of 14,220 patients was defined. Early cholecystectomy was associated with a lower risk of major bile duct injury [0.28% vs 0.53%, relative risk (RR) = 0.53, 95% confidence interval [CI]: 0.31-0.90], of major bile duct injury or death (1.36% vs 1.88%, RR = 0.72, 95% CI: 0.56-0.94), and, albeit non-significant, of 30-day mortality (0.46% vs 0.64%, RR = 0.73, 95% CI: 0.47-1.15). Total hospital length of stay was shorter with early cholecystectomy (mean difference 1.9 days, 95% CI: 1.7-2.1). No significant differences were observed in terms, open cholecystectomy (15% vs 14%, RR = 1.07, 95% CI: 0.99-1.16) or in conversion among laparoscopic cases (11% vs 10%, RR = 1.02, 95% CI: 0.93-1.13). CONCLUSIONS: These results support the benefit of early overdelayed cholecystectomy for patients with acute cholecystitis.

AB - OBJECTIVE: To compare the operative outcomes of early and delayed cholecystectomy for acute cholecystitis. BACKGROUND: Randomized trials comparing early to delayed cholecystectomy for acute cholecystitis have limited contemporary external validity. Furthermore, no study to date has been large enough to assess the impact of timing of cholecystectomy on the frequency of serious rare complications including bile duct injury and death. METHODS: This is a population-based retrospective cohort study of patients emergently admitted to hospital with acute cholecystitis and managed with cholecystectomy over the period of April 1, 2004, to March 31, 2011. We used administrative records for the province of Ontario, Canada. Patients were divided into 2 exposure groups: those who underwent cholecystectomy within 7 days of emergency department presentation on index admission (early cholecystectomy) and those whose cholecystectomy was delayed. The primary outcome was major bile duct injury requiring operative repair within 6 months of cholecystectomy. Secondary outcomes included major bile duct injury or death, 30-day postcholecystectomy mortality, completion of cholecystectomy with an open approach, conversion among laparoscopic cases, and total hospital length of stay. Propensity score methods were used to address confounding by indication. RESULTS: From 22,202 patients, a well-balanced matched cohort of 14,220 patients was defined. Early cholecystectomy was associated with a lower risk of major bile duct injury [0.28% vs 0.53%, relative risk (RR) = 0.53, 95% confidence interval [CI]: 0.31-0.90], of major bile duct injury or death (1.36% vs 1.88%, RR = 0.72, 95% CI: 0.56-0.94), and, albeit non-significant, of 30-day mortality (0.46% vs 0.64%, RR = 0.73, 95% CI: 0.47-1.15). Total hospital length of stay was shorter with early cholecystectomy (mean difference 1.9 days, 95% CI: 1.7-2.1). No significant differences were observed in terms, open cholecystectomy (15% vs 14%, RR = 1.07, 95% CI: 0.99-1.16) or in conversion among laparoscopic cases (11% vs 10%, RR = 1.02, 95% CI: 0.93-1.13). CONCLUSIONS: These results support the benefit of early overdelayed cholecystectomy for patients with acute cholecystitis.

KW - Acute cholecystitis

KW - Bile duct injury

KW - Delayed cholecystectomy

KW - Early cholecystectomy

KW - Laparoscopic cholecystectomy

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