Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

Samirkumar B. Amin, Kevin J. Anderson, C. Elizabeth Boudreau, Emmanuel Martinez-Ledesma, Emre Kocakavuk, Kevin C. Johnson, Floris P. Barthel, Frederick S. Varn, Cynthia Kassab, Xiaoyang Ling, Hoon Kim, Mary Barter, Ching C. Lau, Chew Yee Ngan, Margaret Chapman, Jennifer W. Koehler, James P. Long, Andrew D. Miller, C. Ryan Miller, Brian F. PorterDaniel R. Rissi, Christina Mazcko, Amy K. LeBlanc, Peter J. Dickinson, Rebecca A. Packer, Amanda R. Taylor, John H. Rossmeisl, Kevin D. Woolard, Amy B. Heimberger, Jonathan M. Levine, Roel G.W. Verhaak

Research output: Contribution to journalArticle

Abstract

Amin et al. characterize the molecular landscape of canine gliomas and compare it with that of human pediatric and adult gliomas, revealing high similarity between human pediatric and canine gliomas. The cross-species analysis identifies conserved glioma drivers and aneuploidy as a hallmark of high-grade disease.

Original languageEnglish (US)
Pages (from-to)243-257.e7
JournalCancer Cell
Volume37
Issue number2
DOIs
StatePublished - Feb 10 2020
Externally publishedYes

Keywords

  • adult glioma
  • canine glioma
  • comparative genomics
  • comparative oncology
  • computational biology
  • life history
  • mutagenesis
  • pediatric glioma

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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  • Cite this

    Amin, S. B., Anderson, K. J., Boudreau, C. E., Martinez-Ledesma, E., Kocakavuk, E., Johnson, K. C., Barthel, F. P., Varn, F. S., Kassab, C., Ling, X., Kim, H., Barter, M., Lau, C. C., Ngan, C. Y., Chapman, M., Koehler, J. W., Long, J. P., Miller, A. D., Miller, C. R., ... Verhaak, R. G. W. (2020). Comparative Molecular Life History of Spontaneous Canine and Human Gliomas. Cancer Cell, 37(2), 243-257.e7. https://doi.org/10.1016/j.ccell.2020.01.004