1. 1. Inhibition kinetics of hepatic microsomal mixed function oxidase catalyzed de-ethylation of p-nitrophenetole and naphthalene hydroxylation were studied in swine and sheep using p-nitrobutoxybenzene and carbon monoxide as inhibitors. 2. 2. Lineweaver-Burke plots were obtained which showed non-linear kinetic plots for both animals. 3. 3. Species differences were found in shapes of the kinetic curves. 4. 4. The shape of the kinetic curve was changed by p-nitrobutoxybenzene inhibition, indicating that one region of the curve was more susceptible than others. 5. 5. The implications of this data are discussed in reference to a hypothesis of a system with two enzymes, each having a different affinity, acting on the same substrate.
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