Comparative in-vitro activity of norfioxacin and selected antimicrobial agents against urinary tract pathogens and neisseria gonorrhoeae

Richard L Sweet, Marilyn J. Ohm-smith, W. Keith Hadley

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The in-vitro activity of norfioxacin was compared to that of nalidixic acid, cinoxacin trimethoprim, trimethoprim/sulphamethoxazole, ampicillin, cephalexin, doxycycline, amikacin, and gentamicin against 205 isolates of Gram-negative and Gram-positive bacteria. Norfloxacin was the most effective agent against all of the organisms tested except enterococci and Staphylococcus aureus. The minimal inhibitory concentrations at which at least 90% of the organisms were inhibited (MIC90 were 0·5 mg/l for all Enterobacteriaceae and Pseudomonas aeruginosa, 1·0 mg/l for all staphylococci, and 4·0 mg/l for enterococci.In addition, the activity of norfloxacin was compared to that of penicillin G, ampicillin, cefonicid, cefoxitin, cefuroxime, doxycycline, and spectinomycin against 104 clinical isolates of Neisseria gonorrhoeae. Norfloxacin was the most active with an MIC90 of 0·03 mg/l.

Original languageEnglish (US)
Pages (from-to)553-557
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume10
Issue number6
DOIs
StatePublished - Dec 1982
Externally publishedYes

Fingerprint

Antimicrobial agents
Norfloxacin
Neisseria gonorrhoeae
Pathogens
Anti-Infective Agents
Urinary Tract
Bacteria
Trimethoprim
Doxycycline
Enterococcus
Ampicillin
Acids
Cefonicid
Cinoxacin
Spectinomycin
Cephalexin
Sulfamethoxazole
Cefoxitin
Cefuroxime
Nalidixic Acid

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)
  • Pharmacology
  • Microbiology

Cite this

Comparative in-vitro activity of norfioxacin and selected antimicrobial agents against urinary tract pathogens and neisseria gonorrhoeae. / Sweet, Richard L; Ohm-smith, Marilyn J.; Hadley, W. Keith.

In: Journal of Antimicrobial Chemotherapy, Vol. 10, No. 6, 12.1982, p. 553-557.

Research output: Contribution to journalArticle

@article{99fe49c4a70a47738b2fa9adbe1a27a9,
title = "Comparative in-vitro activity of norfioxacin and selected antimicrobial agents against urinary tract pathogens and neisseria gonorrhoeae",
abstract = "The in-vitro activity of norfioxacin was compared to that of nalidixic acid, cinoxacin trimethoprim, trimethoprim/sulphamethoxazole, ampicillin, cephalexin, doxycycline, amikacin, and gentamicin against 205 isolates of Gram-negative and Gram-positive bacteria. Norfloxacin was the most effective agent against all of the organisms tested except enterococci and Staphylococcus aureus. The minimal inhibitory concentrations at which at least 90{\%} of the organisms were inhibited (MIC90 were 0·5 mg/l for all Enterobacteriaceae and Pseudomonas aeruginosa, 1·0 mg/l for all staphylococci, and 4·0 mg/l for enterococci.In addition, the activity of norfloxacin was compared to that of penicillin G, ampicillin, cefonicid, cefoxitin, cefuroxime, doxycycline, and spectinomycin against 104 clinical isolates of Neisseria gonorrhoeae. Norfloxacin was the most active with an MIC90 of 0·03 mg/l.",
author = "Sweet, {Richard L} and Ohm-smith, {Marilyn J.} and Hadley, {W. Keith}",
year = "1982",
month = "12",
doi = "10.1093/jac/10.6.553",
language = "English (US)",
volume = "10",
pages = "553--557",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Comparative in-vitro activity of norfioxacin and selected antimicrobial agents against urinary tract pathogens and neisseria gonorrhoeae

AU - Sweet, Richard L

AU - Ohm-smith, Marilyn J.

AU - Hadley, W. Keith

PY - 1982/12

Y1 - 1982/12

N2 - The in-vitro activity of norfioxacin was compared to that of nalidixic acid, cinoxacin trimethoprim, trimethoprim/sulphamethoxazole, ampicillin, cephalexin, doxycycline, amikacin, and gentamicin against 205 isolates of Gram-negative and Gram-positive bacteria. Norfloxacin was the most effective agent against all of the organisms tested except enterococci and Staphylococcus aureus. The minimal inhibitory concentrations at which at least 90% of the organisms were inhibited (MIC90 were 0·5 mg/l for all Enterobacteriaceae and Pseudomonas aeruginosa, 1·0 mg/l for all staphylococci, and 4·0 mg/l for enterococci.In addition, the activity of norfloxacin was compared to that of penicillin G, ampicillin, cefonicid, cefoxitin, cefuroxime, doxycycline, and spectinomycin against 104 clinical isolates of Neisseria gonorrhoeae. Norfloxacin was the most active with an MIC90 of 0·03 mg/l.

AB - The in-vitro activity of norfioxacin was compared to that of nalidixic acid, cinoxacin trimethoprim, trimethoprim/sulphamethoxazole, ampicillin, cephalexin, doxycycline, amikacin, and gentamicin against 205 isolates of Gram-negative and Gram-positive bacteria. Norfloxacin was the most effective agent against all of the organisms tested except enterococci and Staphylococcus aureus. The minimal inhibitory concentrations at which at least 90% of the organisms were inhibited (MIC90 were 0·5 mg/l for all Enterobacteriaceae and Pseudomonas aeruginosa, 1·0 mg/l for all staphylococci, and 4·0 mg/l for enterococci.In addition, the activity of norfloxacin was compared to that of penicillin G, ampicillin, cefonicid, cefoxitin, cefuroxime, doxycycline, and spectinomycin against 104 clinical isolates of Neisseria gonorrhoeae. Norfloxacin was the most active with an MIC90 of 0·03 mg/l.

UR - http://www.scopus.com/inward/record.url?scp=0020444011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020444011&partnerID=8YFLogxK

U2 - 10.1093/jac/10.6.553

DO - 10.1093/jac/10.6.553

M3 - Article

C2 - 6219085

AN - SCOPUS:0020444011

VL - 10

SP - 553

EP - 557

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 6

ER -