Comparative Genomics: The Next Generation

Leslie A Lyons, M. M. Raymond, S. J. O'Brien

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Recent advances in human gene mapping technologies have led to increased emphasis in developing representative genetic maps for several species, particularly domestic plants and animals. These maps are being compiled with two distinct goals: to provide a resource for genetic analysis, and to help dissect the evolution of genome organization by comparing linkage relationships of homologous genes. We recently proposed a list of reference anchor loci suitable for comparative gene mapping in mammals and other vertebrate classes. The comparative anchors, which are Type I (coding gene) loci, provide a comparative framework, but the addition of Type II (microsatellite) loci is also necessary for mapping phenotypes in animal gene maps. Strategies for combining the advantages of Type I and Type II locus markers are presented with emphasis on application of these concepts to the construction of a gene map of the domestic cat.

Original languageEnglish (US)
Pages (from-to)103-111
Number of pages9
JournalAnimal Biotechnology
Volume5
Issue number2
DOIs
StatePublished - Oct 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biotechnology
  • Bioengineering

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