Comparative genomics and understanding of microbial biology

C. M. Fraser, Jonathan A Eisen, R. D. Fleischmann, K. A. Ketchum, S. Peterson

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


The sequences of close to 30 microbial genomes have been completed during the past 5 years, and the sequences of more than 100 genomes should be completed in the next 2 to 4 years. Soon, completed microbial genome sequences will represent a collection of >200,000 predicted coding sequences. While analysis of a single genome provides tremendous biological insights on any given organism, comparative analysis of multiple genomes provides substantially more information on the physiology and evolution of microbial species and expands our ability to better assign putative function to predicted coding sequences.

Original languageEnglish (US)
Pages (from-to)505-512
Number of pages8
JournalEmerging Infectious Diseases
Issue number5
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)


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