Comparative gene mapping in the domestic cat (Felis catus)

S. J. O'Brien, S. J. Cevario, J. S. Martenson, M. A. Thompson, W. G. Nash, E. Chang, J. A M Graves, J. A. Spencer, K. W. Cho, H. Tsujimoto, Leslie A Lyons

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The genetic map of the domestic cat has been developed as a model for studying both feline analogues of human genetic disease and comparative genome organization of mammals. We present here the results of syntenic mapping of 35 genes based upon concordant occurrence of feline gene homologues with feline chromosomes and previously mapped loci in a panel of 41 rodent x cat somatic cell hybrids. These somatic cell hybrids retain rodent chromosomes and segregate feline chromosomes, but in different combinations in each hybrid cell line. Thirty-three of the 35 new locus assignments extend and reaffirm conserved chromosome segment homologies between the human and cat genomes previously recognized by comparative mapping and zoo-FISH. These results demonstrate the extensive syntenic conservation between the human end feline genomes and extend the feline gene map to include 105 assigned loci.

Original languageEnglish (US)
Pages (from-to)408-414
Number of pages7
JournalJournal of Heredity
Volume88
Issue number5
StatePublished - Sep 1997
Externally publishedYes

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Chromosome Mapping
Felidae
chromosome mapping
Cats
cats
Hybrid Cells
Chromosomes
chromosomes
Rodentia
Genome
Synteny
somatic cells
Inborn Genetic Diseases
loci
genome
Medical Genetics
Human Genome
rodents
Genes
Mammals

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

O'Brien, S. J., Cevario, S. J., Martenson, J. S., Thompson, M. A., Nash, W. G., Chang, E., ... Lyons, L. A. (1997). Comparative gene mapping in the domestic cat (Felis catus). Journal of Heredity, 88(5), 408-414.

Comparative gene mapping in the domestic cat (Felis catus). / O'Brien, S. J.; Cevario, S. J.; Martenson, J. S.; Thompson, M. A.; Nash, W. G.; Chang, E.; Graves, J. A M; Spencer, J. A.; Cho, K. W.; Tsujimoto, H.; Lyons, Leslie A.

In: Journal of Heredity, Vol. 88, No. 5, 09.1997, p. 408-414.

Research output: Contribution to journalArticle

O'Brien, SJ, Cevario, SJ, Martenson, JS, Thompson, MA, Nash, WG, Chang, E, Graves, JAM, Spencer, JA, Cho, KW, Tsujimoto, H & Lyons, LA 1997, 'Comparative gene mapping in the domestic cat (Felis catus)', Journal of Heredity, vol. 88, no. 5, pp. 408-414.
O'Brien SJ, Cevario SJ, Martenson JS, Thompson MA, Nash WG, Chang E et al. Comparative gene mapping in the domestic cat (Felis catus). Journal of Heredity. 1997 Sep;88(5):408-414.
O'Brien, S. J. ; Cevario, S. J. ; Martenson, J. S. ; Thompson, M. A. ; Nash, W. G. ; Chang, E. ; Graves, J. A M ; Spencer, J. A. ; Cho, K. W. ; Tsujimoto, H. ; Lyons, Leslie A. / Comparative gene mapping in the domestic cat (Felis catus). In: Journal of Heredity. 1997 ; Vol. 88, No. 5. pp. 408-414.
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