Abstract
The cardiocirculatory effects of the commonly used parenteral analgesics, morphine sulfate 15 mg, meperidine hydrochloride 100 mg and pentazocine 60 mg, each administered intravenously, were compared in 12 patients with acute myocardial infarction during cardiac catheterization and by echocardiogram. No untoward hemodynamic effects occurred following the administration of morphine or meperidine. In contrast, pentazocine produced significant (p < 0.01 to < 0.05) increases in systemic and pulmonary arterial pressures, left ventricular filling pressure, systemic vascular resistance, and systolic and diastolic dimensions; and decreases in left ventricular ejection fraction and mean velocity of circumferential fiber shortening. These deleterious actions of pentazocine appeared due to peripheral vasoconstriction and negative inotropic properties. Further, pentazocine-induced increases in left ventricular preload and afterload increased myocardial oxygen demands. Since this study demonstrates that pentazocine is hazardous in myocardial infarction, morphine and meperidine are the preferred analgesics in this condition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 949-955 |
| Number of pages | 7 |
| Journal | The American journal of medicine |
| Volume | 60 |
| Issue number | 7 |
| DOIs | |
| State | Published - 1976 |
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ASJC Scopus subject areas
- Nursing(all)
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Comparative effects of morphine, meperidine and pentazocine on cardiocirculatory dynamics in patients with acute myocardial infarction. / Lee, Garrett; DeMaria, Anthony N.; Amsterdam, Ezra A; Realyvasquez, Fidel; Angel, Juan; Morrison, Stephen; Mason, Dean T.
In: The American journal of medicine, Vol. 60, No. 7, 1976, p. 949-955.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative effects of morphine, meperidine and pentazocine on cardiocirculatory dynamics in patients with acute myocardial infarction
AU - Lee, Garrett
AU - DeMaria, Anthony N.
AU - Amsterdam, Ezra A
AU - Realyvasquez, Fidel
AU - Angel, Juan
AU - Morrison, Stephen
AU - Mason, Dean T.
PY - 1976
Y1 - 1976
N2 - The cardiocirculatory effects of the commonly used parenteral analgesics, morphine sulfate 15 mg, meperidine hydrochloride 100 mg and pentazocine 60 mg, each administered intravenously, were compared in 12 patients with acute myocardial infarction during cardiac catheterization and by echocardiogram. No untoward hemodynamic effects occurred following the administration of morphine or meperidine. In contrast, pentazocine produced significant (p < 0.01 to < 0.05) increases in systemic and pulmonary arterial pressures, left ventricular filling pressure, systemic vascular resistance, and systolic and diastolic dimensions; and decreases in left ventricular ejection fraction and mean velocity of circumferential fiber shortening. These deleterious actions of pentazocine appeared due to peripheral vasoconstriction and negative inotropic properties. Further, pentazocine-induced increases in left ventricular preload and afterload increased myocardial oxygen demands. Since this study demonstrates that pentazocine is hazardous in myocardial infarction, morphine and meperidine are the preferred analgesics in this condition.
AB - The cardiocirculatory effects of the commonly used parenteral analgesics, morphine sulfate 15 mg, meperidine hydrochloride 100 mg and pentazocine 60 mg, each administered intravenously, were compared in 12 patients with acute myocardial infarction during cardiac catheterization and by echocardiogram. No untoward hemodynamic effects occurred following the administration of morphine or meperidine. In contrast, pentazocine produced significant (p < 0.01 to < 0.05) increases in systemic and pulmonary arterial pressures, left ventricular filling pressure, systemic vascular resistance, and systolic and diastolic dimensions; and decreases in left ventricular ejection fraction and mean velocity of circumferential fiber shortening. These deleterious actions of pentazocine appeared due to peripheral vasoconstriction and negative inotropic properties. Further, pentazocine-induced increases in left ventricular preload and afterload increased myocardial oxygen demands. Since this study demonstrates that pentazocine is hazardous in myocardial infarction, morphine and meperidine are the preferred analgesics in this condition.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017179049&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(76)90565-9
DO - 10.1016/0002-9343(76)90565-9
M3 - Article
C2 - 937355
AN - SCOPUS:0017179049
VL - 60
SP - 949
EP - 955
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 7
ER -