Comparative effects of morphine, meperidine and pentazocine on cardiocirculatory dynamics in patients with acute myocardial infarction

Garrett Lee, Anthony N. DeMaria, Ezra A Amsterdam, Fidel Realyvasquez, Juan Angel, Stephen Morrison, Dean T. Mason

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The cardiocirculatory effects of the commonly used parenteral analgesics, morphine sulfate 15 mg, meperidine hydrochloride 100 mg and pentazocine 60 mg, each administered intravenously, were compared in 12 patients with acute myocardial infarction during cardiac catheterization and by echocardiogram. No untoward hemodynamic effects occurred following the administration of morphine or meperidine. In contrast, pentazocine produced significant (p < 0.01 to < 0.05) increases in systemic and pulmonary arterial pressures, left ventricular filling pressure, systemic vascular resistance, and systolic and diastolic dimensions; and decreases in left ventricular ejection fraction and mean velocity of circumferential fiber shortening. These deleterious actions of pentazocine appeared due to peripheral vasoconstriction and negative inotropic properties. Further, pentazocine-induced increases in left ventricular preload and afterload increased myocardial oxygen demands. Since this study demonstrates that pentazocine is hazardous in myocardial infarction, morphine and meperidine are the preferred analgesics in this condition.

Original languageEnglish (US)
Pages (from-to)949-955
Number of pages7
JournalThe American journal of medicine
Volume60
Issue number7
DOIs
StatePublished - 1976

ASJC Scopus subject areas

  • Nursing(all)

Fingerprint Dive into the research topics of 'Comparative effects of morphine, meperidine and pentazocine on cardiocirculatory dynamics in patients with acute myocardial infarction'. Together they form a unique fingerprint.

  • Cite this