Comparative cancer cell signaling in muscle-invasive urothelial carcinoma of the bladder in dogs and humans

Maria Malvina Tsamouri, Thomas M. Steele, Maria Mudryj, Michael S Kent, Paramita M Ghosh

Research output: Contribution to journalArticlepeer-review

Abstract

Muscle-invasive urothelial carcinoma (MIUC) is the most common type of bladder ma-lignancy in humans, but also in dogs that represent a naturally occurring model for this disease. Dogs are immunocompetent animals that share risk factors, pathophysiological features, clinical signs and response to chemotherapeutics with human cancer patients. This review summarizes the fundamental pathways for canine MIUC initiation, progression, and metastasis, emerging therapeutic targets and mechanisms of drug resistance, and proposes new opportunities for potential prognostic and diagnostic biomarkers and therapeutics. Identifying similarities and differences between cancer signaling in dogs and humans is of utmost importance for the efficient translation of in vitro research to successful clinical trials for both species.

Original languageEnglish (US)
Article number1472
JournalBiomedicines
Volume9
Issue number10
DOIs
StatePublished - Oct 2021

Keywords

  • Basic & translational cancer research
  • Bladder cancer
  • Canine cancer
  • Comparative oncology
  • Molecular cancer therapeutics
  • Naturally occurring models of cancer
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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