Comparative biotransformation studies of MeIQx and PhIP in animal models and humans

R. C. Garner; T. J. Lightfoot; B. C. Cupid; D. Russell; J. M. Coxhead; W. Kutschera; A. Priller; W. Rom; P. Steier; D. J. Alexander; S. H. Leveson; K. H. Dingley; R. J. Mauthe; Ken W Turteltaub

doi:10.1016/S0304-3835(99)00118-4

Comparative biotransformation studies of MeIQx and PhIP in animal models and humans

R. C. Garner, T. J. Lightfoot, B. C. Cupid, D. Russell, J. M. Coxhead, W. Kutschera, A. Priller, W. Rom, P. Steier, D. J. Alexander, S. H. Leveson, K. H. Dingley, R. J. Mauthe, Ken W Turteltaub

Research output: Contribution to journal › Article

43 Scopus citations

Abstract

MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have investigated the metabolism and macromolecule binding of ¹⁴C-labelled MeIQx and PhIP in human cancer patients compared to the rat. Following oral administration of MeIQx and PhIP, more DNA adducts were formed in human colon tissue compared with rats. Differences were also observed between rats and humans in the metabolite profile and urine excretion for these compounds. These results suggest humans metabolise heterocyclic amines differently to laboratory rodents and question their use as models of human risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	161-165
Number of pages	5
Journal	Cancer Letters
Volume	143
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(99)00118-4
State	Published - Sep 1999
Externally published	Yes

Keywords

Accelerator mass spectrometry
Colorectal cancer
DNA adduct
Heterocyclic amine

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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Garner, R. C., Lightfoot, T. J., Cupid, B. C., Russell, D., Coxhead, J. M., Kutschera, W., Priller, A., Rom, W., Steier, P., Alexander, D. J., Leveson, S. H., Dingley, K. H., Mauthe, R. J., & Turteltaub, K. W. (1999). Comparative biotransformation studies of MeIQx and PhIP in animal models and humans. Cancer Letters, 143(2), 161-165. https://doi.org/10.1016/S0304-3835(99)00118-4

Comparative biotransformation studies of MeIQx and PhIP in animal models and humans. / Garner, R. C.; Lightfoot, T. J.; Cupid, B. C.; Russell, D.; Coxhead, J. M.; Kutschera, W.; Priller, A.; Rom, W.; Steier, P.; Alexander, D. J.; Leveson, S. H.; Dingley, K. H.; Mauthe, R. J.; Turteltaub, Ken W.

In: Cancer Letters, Vol. 143, No. 2, 09.1999, p. 161-165.

Research output: Contribution to journal › Article

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abstract = "MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have investigated the metabolism and macromolecule binding of 14C-labelled MeIQx and PhIP in human cancer patients compared to the rat. Following oral administration of MeIQx and PhIP, more DNA adducts were formed in human colon tissue compared with rats. Differences were also observed between rats and humans in the metabolite profile and urine excretion for these compounds. These results suggest humans metabolise heterocyclic amines differently to laboratory rodents and question their use as models of human risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "Accelerator mass spectrometry, Colorectal cancer, DNA adduct, Heterocyclic amine",

author = "Garner, {R. C.} and Lightfoot, {T. J.} and Cupid, {B. C.} and D. Russell and Coxhead, {J. M.} and W. Kutschera and A. Priller and W. Rom and P. Steier and Alexander, {D. J.} and Leveson, {S. H.} and Dingley, {K. H.} and Mauthe, {R. J.} and Turteltaub, {Ken W}",

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AB - MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have investigated the metabolism and macromolecule binding of 14C-labelled MeIQx and PhIP in human cancer patients compared to the rat. Following oral administration of MeIQx and PhIP, more DNA adducts were formed in human colon tissue compared with rats. Differences were also observed between rats and humans in the metabolite profile and urine excretion for these compounds. These results suggest humans metabolise heterocyclic amines differently to laboratory rodents and question their use as models of human risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.

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