Comparative biotransformation studies of MeIQx and PhIP in animal models and humans

R. C. Garner, T. J. Lightfoot, B. C. Cupid, D. Russell, J. M. Coxhead, W. Kutschera, A. Priller, W. Rom, P. Steier, D. J. Alexander, S. H. Leveson, K. H. Dingley, R. J. Mauthe, Ken W Turteltaub

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have investigated the metabolism and macromolecule binding of 14C-labelled MeIQx and PhIP in human cancer patients compared to the rat. Following oral administration of MeIQx and PhIP, more DNA adducts were formed in human colon tissue compared with rats. Differences were also observed between rats and humans in the metabolite profile and urine excretion for these compounds. These results suggest humans metabolise heterocyclic amines differently to laboratory rodents and question their use as models of human risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalCancer Letters
Volume143
Issue number2
DOIs
StatePublished - Sep 1999
Externally publishedYes

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Keywords

  • Accelerator mass spectrometry
  • Colorectal cancer
  • DNA adduct
  • Heterocyclic amine

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Garner, R. C., Lightfoot, T. J., Cupid, B. C., Russell, D., Coxhead, J. M., Kutschera, W., Priller, A., Rom, W., Steier, P., Alexander, D. J., Leveson, S. H., Dingley, K. H., Mauthe, R. J., & Turteltaub, K. W. (1999). Comparative biotransformation studies of MeIQx and PhIP in animal models and humans. Cancer Letters, 143(2), 161-165. https://doi.org/10.1016/S0304-3835(99)00118-4