Comparative biotransformation studies of MeIQx and PhIP in animal models and humans

R. C. Garner, T. J. Lightfoot, B. C. Cupid, D. Russell, J. M. Coxhead, W. Kutschera, A. Priller, W. Rom, P. Steier, D. J. Alexander, S. H. Leveson, K. H. Dingley, R. J. Mauthe, Ken W Turteltaub

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have investigated the metabolism and macromolecule binding of 14C-labelled MeIQx and PhIP in human cancer patients compared to the rat. Following oral administration of MeIQx and PhIP, more DNA adducts were formed in human colon tissue compared with rats. Differences were also observed between rats and humans in the metabolite profile and urine excretion for these compounds. These results suggest humans metabolise heterocyclic amines differently to laboratory rodents and question their use as models of human risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalCancer Letters
Volume143
Issue number2
DOIs
StatePublished - Sep 1999
Externally publishedYes

Fingerprint

Biotransformation
Animal Models
Amines
Cooking
Meat
Oral Administration
Rodentia
Mass Spectrometry
Colon
Fishes
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
Urine
Neoplasms

Keywords

  • Accelerator mass spectrometry
  • Colorectal cancer
  • DNA adduct
  • Heterocyclic amine

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Garner, R. C., Lightfoot, T. J., Cupid, B. C., Russell, D., Coxhead, J. M., Kutschera, W., ... Turteltaub, K. W. (1999). Comparative biotransformation studies of MeIQx and PhIP in animal models and humans. Cancer Letters, 143(2), 161-165. https://doi.org/10.1016/S0304-3835(99)00118-4

Comparative biotransformation studies of MeIQx and PhIP in animal models and humans. / Garner, R. C.; Lightfoot, T. J.; Cupid, B. C.; Russell, D.; Coxhead, J. M.; Kutschera, W.; Priller, A.; Rom, W.; Steier, P.; Alexander, D. J.; Leveson, S. H.; Dingley, K. H.; Mauthe, R. J.; Turteltaub, Ken W.

In: Cancer Letters, Vol. 143, No. 2, 09.1999, p. 161-165.

Research output: Contribution to journalArticle

Garner, RC, Lightfoot, TJ, Cupid, BC, Russell, D, Coxhead, JM, Kutschera, W, Priller, A, Rom, W, Steier, P, Alexander, DJ, Leveson, SH, Dingley, KH, Mauthe, RJ & Turteltaub, KW 1999, 'Comparative biotransformation studies of MeIQx and PhIP in animal models and humans', Cancer Letters, vol. 143, no. 2, pp. 161-165. https://doi.org/10.1016/S0304-3835(99)00118-4
Garner RC, Lightfoot TJ, Cupid BC, Russell D, Coxhead JM, Kutschera W et al. Comparative biotransformation studies of MeIQx and PhIP in animal models and humans. Cancer Letters. 1999 Sep;143(2):161-165. https://doi.org/10.1016/S0304-3835(99)00118-4
Garner, R. C. ; Lightfoot, T. J. ; Cupid, B. C. ; Russell, D. ; Coxhead, J. M. ; Kutschera, W. ; Priller, A. ; Rom, W. ; Steier, P. ; Alexander, D. J. ; Leveson, S. H. ; Dingley, K. H. ; Mauthe, R. J. ; Turteltaub, Ken W. / Comparative biotransformation studies of MeIQx and PhIP in animal models and humans. In: Cancer Letters. 1999 ; Vol. 143, No. 2. pp. 161-165.
@article{5e6b9e758bd048d4932add52eec215d5,
title = "Comparative biotransformation studies of MeIQx and PhIP in animal models and humans",
abstract = "MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have investigated the metabolism and macromolecule binding of 14C-labelled MeIQx and PhIP in human cancer patients compared to the rat. Following oral administration of MeIQx and PhIP, more DNA adducts were formed in human colon tissue compared with rats. Differences were also observed between rats and humans in the metabolite profile and urine excretion for these compounds. These results suggest humans metabolise heterocyclic amines differently to laboratory rodents and question their use as models of human risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.",
keywords = "Accelerator mass spectrometry, Colorectal cancer, DNA adduct, Heterocyclic amine",
author = "Garner, {R. C.} and Lightfoot, {T. J.} and Cupid, {B. C.} and D. Russell and Coxhead, {J. M.} and W. Kutschera and A. Priller and W. Rom and P. Steier and Alexander, {D. J.} and Leveson, {S. H.} and Dingley, {K. H.} and Mauthe, {R. J.} and Turteltaub, {Ken W}",
year = "1999",
month = "9",
doi = "10.1016/S0304-3835(99)00118-4",
language = "English (US)",
volume = "143",
pages = "161--165",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Comparative biotransformation studies of MeIQx and PhIP in animal models and humans

AU - Garner, R. C.

AU - Lightfoot, T. J.

AU - Cupid, B. C.

AU - Russell, D.

AU - Coxhead, J. M.

AU - Kutschera, W.

AU - Priller, A.

AU - Rom, W.

AU - Steier, P.

AU - Alexander, D. J.

AU - Leveson, S. H.

AU - Dingley, K. H.

AU - Mauthe, R. J.

AU - Turteltaub, Ken W

PY - 1999/9

Y1 - 1999/9

N2 - MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have investigated the metabolism and macromolecule binding of 14C-labelled MeIQx and PhIP in human cancer patients compared to the rat. Following oral administration of MeIQx and PhIP, more DNA adducts were formed in human colon tissue compared with rats. Differences were also observed between rats and humans in the metabolite profile and urine excretion for these compounds. These results suggest humans metabolise heterocyclic amines differently to laboratory rodents and question their use as models of human risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have investigated the metabolism and macromolecule binding of 14C-labelled MeIQx and PhIP in human cancer patients compared to the rat. Following oral administration of MeIQx and PhIP, more DNA adducts were formed in human colon tissue compared with rats. Differences were also observed between rats and humans in the metabolite profile and urine excretion for these compounds. These results suggest humans metabolise heterocyclic amines differently to laboratory rodents and question their use as models of human risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - Accelerator mass spectrometry

KW - Colorectal cancer

KW - DNA adduct

KW - Heterocyclic amine

UR - http://www.scopus.com/inward/record.url?scp=0032806626&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032806626&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(99)00118-4

DO - 10.1016/S0304-3835(99)00118-4

M3 - Article

VL - 143

SP - 161

EP - 165

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -