Comparative biological features of a rat liver abscess model induced with three Fusobacterium necrophorum strains.

C. M. Scanlan, J. N. Berg, Michael Dale Lairmore

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Several biological features were compared in a rat liver abscess model, using intraportal inoculations with 3 bovine strains of Fusobacterium necrophorum which varied in virulence. Serum alanine aminotransferase activities were increased significantly (P less than 0.05) in rats inoculated with F necrophorum 2101 by postinoculation hours 6, 12, and 24. Thereafter, alanine aminotransferase values returned to base line for the remainder of the experiment. Also, rats inoculated with F necrophorum 2101 had a significantly greater (P less than 0.05) weight loss than did the control rats during the first 5 postinoculation days and developed leukocytosis characterized by a neutrophilia with a left shift. The duration of the bacteremia was related directly to the virulence of the F necrophorum strain. Fusobacterium necrophorum 2101, a biotype A which was the most virulent, induced the most persistent bacteremia; F necrophorum 2035, a biotype B which was the least virulent, produced the shortest bacteremia; and F necrophorum 2030, a biotype AB which was of intermediate virulence, led to bacteremia of intermediate duration. Plasma endotoxin was demonstrated intermittently during the first 24 hours, but did not correlate with the bacteremia.

Original languageEnglish (US)
Pages (from-to)1789-1792
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume44
Issue number9
StatePublished - Sep 1983
Externally publishedYes

Fingerprint

Fusobacterium necrophorum
liver abscess
Liver Abscess
bacteremia
Bacteremia
biotypes
rats
Virulence
virulence
Alanine Transaminase
alanine transaminase
duration
Leukocytosis
endotoxins
Endotoxins
Weight Loss
weight loss
cattle
Serum

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Comparative biological features of a rat liver abscess model induced with three Fusobacterium necrophorum strains. / Scanlan, C. M.; Berg, J. N.; Lairmore, Michael Dale.

In: American Journal of Veterinary Research, Vol. 44, No. 9, 09.1983, p. 1789-1792.

Research output: Contribution to journalArticle

@article{6474441910d144a6aa8a2c3d95be42cd,
title = "Comparative biological features of a rat liver abscess model induced with three Fusobacterium necrophorum strains.",
abstract = "Several biological features were compared in a rat liver abscess model, using intraportal inoculations with 3 bovine strains of Fusobacterium necrophorum which varied in virulence. Serum alanine aminotransferase activities were increased significantly (P less than 0.05) in rats inoculated with F necrophorum 2101 by postinoculation hours 6, 12, and 24. Thereafter, alanine aminotransferase values returned to base line for the remainder of the experiment. Also, rats inoculated with F necrophorum 2101 had a significantly greater (P less than 0.05) weight loss than did the control rats during the first 5 postinoculation days and developed leukocytosis characterized by a neutrophilia with a left shift. The duration of the bacteremia was related directly to the virulence of the F necrophorum strain. Fusobacterium necrophorum 2101, a biotype A which was the most virulent, induced the most persistent bacteremia; F necrophorum 2035, a biotype B which was the least virulent, produced the shortest bacteremia; and F necrophorum 2030, a biotype AB which was of intermediate virulence, led to bacteremia of intermediate duration. Plasma endotoxin was demonstrated intermittently during the first 24 hours, but did not correlate with the bacteremia.",
author = "Scanlan, {C. M.} and Berg, {J. N.} and Lairmore, {Michael Dale}",
year = "1983",
month = "9",
language = "English (US)",
volume = "44",
pages = "1789--1792",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "9",

}

TY - JOUR

T1 - Comparative biological features of a rat liver abscess model induced with three Fusobacterium necrophorum strains.

AU - Scanlan, C. M.

AU - Berg, J. N.

AU - Lairmore, Michael Dale

PY - 1983/9

Y1 - 1983/9

N2 - Several biological features were compared in a rat liver abscess model, using intraportal inoculations with 3 bovine strains of Fusobacterium necrophorum which varied in virulence. Serum alanine aminotransferase activities were increased significantly (P less than 0.05) in rats inoculated with F necrophorum 2101 by postinoculation hours 6, 12, and 24. Thereafter, alanine aminotransferase values returned to base line for the remainder of the experiment. Also, rats inoculated with F necrophorum 2101 had a significantly greater (P less than 0.05) weight loss than did the control rats during the first 5 postinoculation days and developed leukocytosis characterized by a neutrophilia with a left shift. The duration of the bacteremia was related directly to the virulence of the F necrophorum strain. Fusobacterium necrophorum 2101, a biotype A which was the most virulent, induced the most persistent bacteremia; F necrophorum 2035, a biotype B which was the least virulent, produced the shortest bacteremia; and F necrophorum 2030, a biotype AB which was of intermediate virulence, led to bacteremia of intermediate duration. Plasma endotoxin was demonstrated intermittently during the first 24 hours, but did not correlate with the bacteremia.

AB - Several biological features were compared in a rat liver abscess model, using intraportal inoculations with 3 bovine strains of Fusobacterium necrophorum which varied in virulence. Serum alanine aminotransferase activities were increased significantly (P less than 0.05) in rats inoculated with F necrophorum 2101 by postinoculation hours 6, 12, and 24. Thereafter, alanine aminotransferase values returned to base line for the remainder of the experiment. Also, rats inoculated with F necrophorum 2101 had a significantly greater (P less than 0.05) weight loss than did the control rats during the first 5 postinoculation days and developed leukocytosis characterized by a neutrophilia with a left shift. The duration of the bacteremia was related directly to the virulence of the F necrophorum strain. Fusobacterium necrophorum 2101, a biotype A which was the most virulent, induced the most persistent bacteremia; F necrophorum 2035, a biotype B which was the least virulent, produced the shortest bacteremia; and F necrophorum 2030, a biotype AB which was of intermediate virulence, led to bacteremia of intermediate duration. Plasma endotoxin was demonstrated intermittently during the first 24 hours, but did not correlate with the bacteremia.

UR - http://www.scopus.com/inward/record.url?scp=0020822841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020822841&partnerID=8YFLogxK

M3 - Article

C2 - 6625335

AN - SCOPUS:0020822841

VL - 44

SP - 1789

EP - 1792

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 9

ER -