Comparative Aspects of Mammalian Cortical Development

Research output: Chapter in Book/Report/Conference proceedingChapter


The size of the cerebral cortex and the degree of cortical folding varies greatly among mammals. Yet, key developmental features are shared across species. Examination of the proliferative zones of vertebrates ranging from reptiles to primates has shed light on when specific precursor cell types first appeared during evolution and how they might contribute to the radial and tangential expansion of the cerebral cortex, both developmentally and evolutionarily. This chapter reviews recent work that has phenotyped the subventricular zone and neural precursor cells across mammalian and nonmammalian species.

Original languageEnglish (US)
Title of host publicationEvolution of Nervous Systems
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages7
ISBN (Electronic)9780128040423
ISBN (Print)9780128040966
StatePublished - Jan 1 2016


  • Cerebral cortex
  • Intermediate progenitor cells (IP cells)
  • Mammal
  • Marsupial
  • Pax6
  • Proliferation
  • Radial glial cells (RG cells)
  • Reptile
  • Subventricular zone (SVZ)
  • Tbr2
  • Ventricular zone (VZ)

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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