Comparative analysis of the effects of nomegestrol acetate/17 β-estradiol and drospirenone/ethinylestradiol on premenstrual and menstrual symptoms and dysmenorrhea

Han Witjes, Mitchell D Creinin, Inger Sundström-Poromaa, Allison Martin Nguyen, Tjeerd Korver

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Objectives To compare premenstrual and menstrual symptoms in healthy women using nomegestrol acetate/17β-estradiol (NOMAC/E2) and drospirenone/ethinylestradiol (DRSP/EE) via the Moos Menstrual Distress Questionnaire Form C (MDQ-C). Methods Women completed the MDQ-C at baseline and after completion of cycles 1, 3, 6 and 13, for the premenstrual (four days before most recent flow) and menstrual (most recent flow) phases in two randomized controlled trials. Treatment effects of NOMAC/E2 and DRSP/EE on the t-scores of eight MDQ-C symptom domains from 3522 women were examined, and the effects of both treatments on the score for cramps from 1779 women with moderate to severe cramps at baseline. Longitudinal data analysis methods were applied in both analyses. Results NOMAC/E2 users experienced a significant improvement in Pain, Water Retention, Negative Affect, Impaired Concentration and Behaviour Change domain scores in the menstrual phase compared with DRSP/EE users (p < 0.001 for all comparisons). However, Arousal (emotional and mental) scores worsened with NOMAC/E2 but not with DRSP/EE. Women with moderate to severe cramps experienced an improvement in the cramps score with NOMAC/E2 and DRSP/EE. Conclusions NOMAC/E2 was effective in reducing most premenstrual and menstrual symptoms, and was associated with significantly greater improvements in many MDQ-C domain scores compared with DRSP/EE. (ClinicalTrials.gov: NCT00413062 and NCT00511199).

Original languageEnglish (US)
Pages (from-to)296-307
Number of pages12
JournalEuropean Journal of Contraception and Reproductive Health Care
Volume20
Issue number4
DOIs
StatePublished - Aug 1 2015

Keywords

  • 17β-estradiol
  • Combined oral contraceptive
  • Drospirenone
  • DRSP/EE
  • Ethinylestradiol
  • MDQ
  • NOMAC/E2
  • Nomegestrol acetate

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pharmacology (medical)
  • Reproductive Medicine

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