Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates

Barun K. De, Michael Dale Lairmore, Kevin Griffis, Laurina J. Williams, Francois Villinger, Thomas C. Quinn, Christopher Brown, Nzilambi, Mineharu Sugimoto, Shukuro Araki, Thomas M. Folks

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31 Scopus citations

Abstract

Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAMITSP). The nucleotide sequences of 640 by of the proviral genome (positions 5158-5797) derived from 11 HTLV-I-infected persons were analyzed using the polymerase chain reaction and M13-based sequencing techniques. Patterns of single nucleotide substitutions were characterized from the extracellular domain of the envelope gene (gp46). Compared with other retroviruses, the nucleotide sequences of the HTLV-I external envelope gene are highly conserved among the genotypes studied. We found no evidence of dual infections with HTLV-II among the seropositive asymptomatic persons or in patients with either ATL or HAMITSP. No unique sequence differences were observed in the envelope gene of the HTLV-I isolates derived from patients coinfected with human immunodeficiency virus type 1 (HIV-1). However, comparative analysis of these data and other published HTLV-I envelope sequences indicated the presence of four subtypes of HTLV-I in relation to their geographic origin.

Original languageEnglish (US)
Pages (from-to)413-419
Number of pages7
JournalVirology
Volume182
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    De, B. K., Lairmore, M. D., Griffis, K., Williams, L. J., Villinger, F., Quinn, T. C., Brown, C., Nzilambi, Sugimoto, M., Araki, S., & Folks, T. M. (1991). Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates. Virology, 182(1), 413-419. https://doi.org/10.1016/0042-6822(91)90692-5