Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates

Barun K. De, Michael Dale Lairmore, Kevin Griffis, Laurina J. Williams, Francois Villinger, Thomas C. Quinn, Christopher Brown, Nzilambi, Mineharu Sugimoto, Shukuro Araki, Thomas M. Folks

Research output: Contribution to journalArticle

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Abstract

Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAMITSP). The nucleotide sequences of 640 by of the proviral genome (positions 5158-5797) derived from 11 HTLV-I-infected persons were analyzed using the polymerase chain reaction and M13-based sequencing techniques. Patterns of single nucleotide substitutions were characterized from the extracellular domain of the envelope gene (gp46). Compared with other retroviruses, the nucleotide sequences of the HTLV-I external envelope gene are highly conserved among the genotypes studied. We found no evidence of dual infections with HTLV-II among the seropositive asymptomatic persons or in patients with either ATL or HAMITSP. No unique sequence differences were observed in the envelope gene of the HTLV-I isolates derived from patients coinfected with human immunodeficiency virus type 1 (HIV-1). However, comparative analysis of these data and other published HTLV-I envelope sequences indicated the presence of four subtypes of HTLV-I in relation to their geographic origin.

Original languageEnglish (US)
Pages (from-to)413-419
Number of pages7
JournalVirology
Volume182
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

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Viruses
Genes
Adult T Cell Leukemia Lymphoma
HTLV-II Infections
Tropical Spastic Paraparesis
Spinal Cord Diseases
Retroviridae
HIV-1
Nucleotides
Genotype
Genome
T-Lymphocytes
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates. / De, Barun K.; Lairmore, Michael Dale; Griffis, Kevin; Williams, Laurina J.; Villinger, Francois; Quinn, Thomas C.; Brown, Christopher; Nzilambi; Sugimoto, Mineharu; Araki, Shukuro; Folks, Thomas M.

In: Virology, Vol. 182, No. 1, 1991, p. 413-419.

Research output: Contribution to journalArticle

De, BK, Lairmore, MD, Griffis, K, Williams, LJ, Villinger, F, Quinn, TC, Brown, C, Nzilambi, Sugimoto, M, Araki, S & Folks, TM 1991, 'Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates', Virology, vol. 182, no. 1, pp. 413-419. https://doi.org/10.1016/0042-6822(91)90692-5
De, Barun K. ; Lairmore, Michael Dale ; Griffis, Kevin ; Williams, Laurina J. ; Villinger, Francois ; Quinn, Thomas C. ; Brown, Christopher ; Nzilambi ; Sugimoto, Mineharu ; Araki, Shukuro ; Folks, Thomas M. / Comparative analysis of nucleotide sequences of the partial envelope gene (5′ Domain) among human T lymphotropic virus type I(HTLV-I) isolates. In: Virology. 1991 ; Vol. 182, No. 1. pp. 413-419.
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