Abstract

Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.

Original languageEnglish (US)
Article number308ps21
JournalScience Translational Medicine
Volume7
Issue number308
DOIs
StatePublished - Oct 7 2015

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Pets
Clinical Trials
Translational Medical Research
Veterinary Medicine
Animal Models
Equipment and Supplies
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Companion animals: Translational scientist's new best friends",
abstract = "Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.",
author = "Amir Kol and Boaz Arzi and Athanasiou, {Kyriacos A.} and Farmer, {Diana L} and Jan Nolta and Rebhun, {Robert B} and Xinbin Chen and Griffiths, {Leigh G.} and Verstraete, {Frank J} and Murphy, {Christopher J} and Borjesson, {Dori L}",
year = "2015",
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doi = "10.1126/scitranslmed.aaa9116",
language = "English (US)",
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journal = "Science Translational Medicine",
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AU - Kol, Amir

AU - Arzi, Boaz

AU - Athanasiou, Kyriacos A.

AU - Farmer, Diana L

AU - Nolta, Jan

AU - Rebhun, Robert B

AU - Chen, Xinbin

AU - Griffiths, Leigh G.

AU - Verstraete, Frank J

AU - Murphy, Christopher J

AU - Borjesson, Dori L

PY - 2015/10/7

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AB - Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.

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