Comorbid forms of psychopathology: Key patterns and future research directions

Magdalena Cerda, Aditi Sagdeo, Sandro Galea

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

The purpose of this review is to systematically appraise the peer-reviewed literature about clustered forms of psychopathology and to present a framework that can be useful for studying comorbid psychiatric disorders. The review focuses on four of the most prevalent types of mental health problems: anxiety, depression, conduct disorder, and substance abuse. The authors summarize existing empirical research on the distribution of concurrent and sequential comorbidity in children and adolescents and in adults, and they review existing knowledge about exogenous risk factors that influence comorbidity. The authors include articles that used a longitudinal study design and used psychiatric definitions of the disorders. A total of 58 articles met the inclusion criteria and were assessed. Current evidence demonstrates a reciprocal, sequential relation between most comorbid pairs, although the mechanisms that mediate such links remain to be explained. Methodological concerns include the inconsistency of measurement of the disorders across studies, small sample sizes, and restricted follow-up times. Given the significant mental health burden placed by comorbid disorders, and their high prevalence across populations, research on the key risk factors for clustering of psychopathology is needed.

Original languageEnglish (US)
Pages (from-to)155-177
Number of pages23
JournalEpidemiologic Reviews
Volume30
Issue number1
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

Keywords

  • Anxiety
  • Comorbidity
  • Conduct disorder
  • Depression
  • Social conditions
  • Substance-related disorders

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Comorbid forms of psychopathology: Key patterns and future research directions'. Together they form a unique fingerprint.

Cite this