Abstract
Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect most warm-blooded animals and cause severe and life-threatening disease in developing fetuses and in immune-compromised patients. Although Toxoplasma was discovered over 100 years ago, we are only now beginning to appreciate the importance of the role that parasite modulation of its host has on parasite growth, bradyzoite development, immune evasion, and virulence. The goal of this review is to highlight these findings, to develop an integrated model for communication between Toxoplasma and its host, and to discuss new questions that arise out of these studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 458-476 |
| Number of pages | 19 |
| Journal | APMIS |
| Volume | 117 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - May 2009 |
| Externally published | Yes |
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Keywords
- Apicomplexan
- Host-parasite interactions
- Immune response
- Toxoplasma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Microbiology (medical)
- Immunology and Allergy
Cite this
Communication between Toxoplasma gondii and its host : Impact on parasite growth, development, immune evasion, and virulence. / Blader, Ira J.; Saeij, Jeroen.
In: APMIS, Vol. 117, No. 5-6, 05.2009, p. 458-476.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Communication between Toxoplasma gondii and its host
T2 - Impact on parasite growth, development, immune evasion, and virulence
AU - Blader, Ira J.
AU - Saeij, Jeroen
PY - 2009/5
Y1 - 2009/5
N2 - Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect most warm-blooded animals and cause severe and life-threatening disease in developing fetuses and in immune-compromised patients. Although Toxoplasma was discovered over 100 years ago, we are only now beginning to appreciate the importance of the role that parasite modulation of its host has on parasite growth, bradyzoite development, immune evasion, and virulence. The goal of this review is to highlight these findings, to develop an integrated model for communication between Toxoplasma and its host, and to discuss new questions that arise out of these studies.
AB - Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect most warm-blooded animals and cause severe and life-threatening disease in developing fetuses and in immune-compromised patients. Although Toxoplasma was discovered over 100 years ago, we are only now beginning to appreciate the importance of the role that parasite modulation of its host has on parasite growth, bradyzoite development, immune evasion, and virulence. The goal of this review is to highlight these findings, to develop an integrated model for communication between Toxoplasma and its host, and to discuss new questions that arise out of these studies.
KW - Apicomplexan
KW - Host-parasite interactions
KW - Immune response
KW - Toxoplasma
UR - http://www.scopus.com/inward/record.url?scp=65349094083&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65349094083&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0463.2009.02453.x
DO - 10.1111/j.1600-0463.2009.02453.x
M3 - Review article
C2 - 19400868
AN - SCOPUS:65349094083
VL - 117
SP - 458
EP - 476
JO - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section B Microbiology
JF - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section B Microbiology
SN - 0365-5555
IS - 5-6
ER -