Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Malcolm G. Dunlop, Sara E. Dobbins, Susan Mary Farrington, Angela M. Jones, Claire Palles, Nicola Whiffin, Albert Tenesa, Sarah Spain, Peter Broderick, Li Yin Ooi, Enric Domingo, Claire Smillie, Marc Henrion, Matthew Frampton, Lynn Martin, Graeme Grimes, Maggie Gorman, Colin Semple, Yusanne P. Ma, Ella BarclayJames Prendergast, Jean Baptiste Cazier, Bianca Olver, Steven Penegar, Steven Lubbe, Ian Chander, Luis Carvajal-Carmona, Stephane Ballereau, Amy Lloyd, Jayaram Vijayakrishnan, Lina Zgaga, Igor Rudan, Evropi Theodoratou, Huw Thomas, Eamonn Maher, Gareth Evans, Lisa Walker, Dorothy Halliday, Anneke Lucassen, Joan Paterson, Shirley Hodgson, Tessa Homfray, Lucy Side, Louise Izatt, Alan Donaldson, Susan Tomkins, Patrick Morrison, Carole Brewer, Alex Henderson, Rosemarie Davidson, Victoria Murday, Jaqueline Cook, Neva Haites, Timothy Bishop, Eamonn Sheridan, Andrew Green, Christopher Marks, Sue Carpenter, Mary Broughton, Lynn Greenhalge, Mohnish Suri, John M. Starr, Ian Deary, Iva Kirac, Dujo Kovacevia, Lauri A. Aaltonen, Laura Renkonen-Sinisalo, Jukka Pekka Mecklin, Koichi Matsuda, Yusuke Nakamura, Yukinori Okada, Steven Gallinger, David J. Duggan, David Conti, Polly Newcomb, John Hopper, Mark A. Jenkins, Fredrick Schumacher, Graham Casey, Douglas Easton, Mitul Shah, Paul Pharoah, Annika Lindblom, Tao Liu, David Edler, Claes Lenander, Johan Dalén, Fredrik Hjern, Nils Lundqvist, Ulrik Lindforss, Lars Påhlman, Kennet Smedh, Anders Törnqvist, Jörn Holm, Martin Janson, Magnus Andersson, Susanne Ekelund, Louise Olsson, Christopher G. Smith, Hannah West, Jeremy P. Cheadle, Graham MacDonald, Leslie M. Samuel, Athar Ahmad, Philippa Corrie, Duncan Jodrell, Cheryl Palmer, Charles Wilson, Julie O'Hagan, David Smith, Ray McDermott, Janice Walshe, James Cassidy, Alec McDonald, Nazia Mohammed, Jeff White, Hosney Yosef, Oscar Breathnach, Liam Grogan, Robert Thomas, Martin Eatock, Paul Henry, Russell Houston, Patrick Johnston, Richard Wilson, Ian Geh, Falalu Danwata, Andrew Hindley, Shabbir Susnerwala, Chris Bradley, Andrew Conn, Anne Raine, Chris Twelves, Stephen Falk, Kirstin Hopkins, Saad Tahir, Amandeep Dhadda, Anthony Maraveyas, Joseph Sgouros, Mark Teo, Rizvana Ahmad, Susan Cleator, Antonia Creak, Charles Lowdell, Philippa Riddle, Kim Benstead, David Farrugia, Nicholas Reed, Stephen Shepherd, Edward Levine, Saifee Mullamitha, Mark Saunders, Juan Valle, Gregory Wilson, Adam Jones, Andrew Weaver, Peter I. Clark, Brain Haylock, Mussawar I. Iqbal, Arthur S. Myint, Sharon Beesley, Timothy Sevitt, Jonathan Nicoll, Francis Daniel, Victoria Ford, Toby Talbot, Mohammad Butt, Abdel Hamid, Paul MacK, Raj Roy, Richard Osborne, Fiona McKinna, Heidar Alsab, Devyanee Basu, Phillip Murray, Bruce Sizer, Faisal A. Azam, Rekha Neupane, Ashita Waterston, John Glaholm, Claire Blesing, Sarah Lowndes, Aruna Medisetti, Andrew Gaya, Martin Leslie, Nicholas Maisey, Paul Ross, Grainne Dunn, Omar Al-Salihi, Harpreet S. Wasan, Li Tee Tan, Jo Dent, Uschi Hofmann, Johnathan K. Joffe, Elizabeth Sherwin, Rabinder Soomal, Amitabha Chakrabarti, Shibu Joseph, Johannes Van Der Voet, Nicholas J. Wadd, David Wilson, Salim Anjarwalia, Julia Hall, Rob Hughes, Andrew Polychronis, John H. Scarffe, Mark Hill, Rodger D. James, Riyaz Shah, Jeffrey Summers, Andrew Hartley, Desmond Carney, John McCaffrey, Brano Bystricky, Seamus O'Reilly, Rajnish Gupta, Talib Al-Mishlab, Fiona Gidden, Richard O'Hara, Jill Stewart, Richard Ashford, Robert Glynne-Jones, Mark Harrison, Suzannah Mawdsley, Hilary Barlow, Mary Tighe, Julie Walther, Janet Neal, Charlotte Rees, John Bridgewater, Stephen Karp, Ursula McGovern, Philip J. Atherton, Hany El-Deeb, Craig MacMillan, Kinnari Patel, Eric Michael Bessell, Peter D. Dickinson, Vanessa Potter, Catherine Jephcott, Karen McAdam, Jessica Wrigley, Sethupathi Muthuramalingam, Anne O'Callaghan, Lucinda Melcher, Chiara Braconi, Ju Ian Geh, Dan Palmer, Priya Narayana, Neil Steven, Andres Gaya, Sarah Rudman, Prabir Chakraborti, Kay Kelly, Carol MacGregor, David Whillis, Alice Freebairn, James Gildersleve, Sahid Sharif, George Astras, Tamas Hickish, Darren Beech, Richard Ellis, Rajendra Kulkarni, K. Shankland, Richard Begent, Astrid Mayer, Timothy Meyer, Sandra Strauss, Viriginia Hall, Sanjay Raj, Ian Chau, David Cunningham, Alison Birtle, Ashoke Biswas, Marcus Wise, Sebastian Cummins, Sharadah Essapen, Gary Middleton, Claire Topham, Ruth Langley, Andrew Webb, Marie Wilkins, Timothy John Iveson, Colin Askill, John Wagstaff, Ashraf Azzabi, Adrian Bateman, Jan Prejbisz, David Tsang, Nasim Ali, Amanda Jones, Paul O'Neill, Christopher Cottrill, David Propper, Fiona Jane Lofts, James Kennedy, David A. Anthoney, Rachel Cooper, Adrian Crellin, Alan Melcher, Matthew Seymour, Christopher Baughan, Emma Alexander, John Crown, David Fennelly, Fawzi Adab, Selvaraj Giridharan, Ian Pedley, Kathryn Wright, Peter Bliss, Geoffrey Cogill, Nangi Lo, Elizabeth Toy, Daniel Hochhauser, Jonathan Ledermann, Alison Brewster, Timothy Maughan, Diana Mort, Somnath Mukherjee, Werner Dobrowsky, Paula Calvert, Gregory Leonard, Hugo Ford, Anne Margeret Moody, Sonia Goriah, Margeret Wilkins, Sally Clive, Lesley Dawson, Catriona McLean, Hamish Andrew Phillips, Kakumudi Gopi, Marjorie Tomlinson, Susan Clenton, Debra Furniss, Joanne Hornbuckle, Simon Pledge, Jonathan Wadsley, Mohammed Abbas, Ernest Marshall, Catherine Harper-Wynne, Anne Barnes, Satish Kumar, Vallipuram Vigneswaran, Simon Gollins, M. Genton, Geoff Sparrow, Catherine Bale, C. Fuller, Anna Mullard, Nicholas Stuart, Rachel Williams, MacCon Keane, Tim Maughen, Richard Adams, Ayman Madi, Elizabeth Hodgkinson, Penny Rogers, Malcolm Pope, Rick Kaplan, Angela Meade, Mahesh Parmar, Sarah Kenny, David Fisher, Lynda Harper, Jena Mitchell, Laura Nichols, Benjamin Sydes, Louise Clement, Edward Kay, Cheryl Courtney, Madalena Gallagher, Claire Murphy, Lindsay Thompson, Sarah Beall, Sharma Hassan, Richard Gracie, Gareth Griffiths, Malcolm Mason, Chris Parker, Robin Rudd, Patrick Johnson, Jeremy Whelan, John Northover, Julia Brown, Matti Aapro, Ronald Stout, Rachel Midgley, David J. Kerr, Harry Campbell, Ian P. Tomlinson, Richard S. Houlston

Research output: Contribution to journalArticlepeer-review

166 Scopus citations

Abstract

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

Original languageEnglish (US)
Pages (from-to)770-776
Number of pages7
JournalNature Genetics
Volume44
Issue number7
DOIs
StatePublished - Jul 2012
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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