Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Malcolm G. Dunlop, Sara E. Dobbins, Susan Mary Farrington, Angela M. Jones, Claire Palles, Nicola Whiffin, Albert Tenesa, Sarah Spain, Peter Broderick, Li Yin Ooi, Enric Domingo, Claire Smillie, Marc Henrion, Matthew Frampton, Lynn Martin, Graeme Grimes, Maggie Gorman, Colin Semple, Yusanne P. Ma, Ella BarclayJames Prendergast, Jean Baptiste Cazier, Bianca Olver, Steven Penegar, Steven Lubbe, Ian Chander, Luis Carvajal-Carmona, Stephane Ballereau, Amy Lloyd, Jayaram Vijayakrishnan, Lina Zgaga, Igor Rudan, Evropi Theodoratou, Huw Thomas, Eamonn Maher, Gareth Evans, Lisa Walker, Dorothy Halliday, Anneke Lucassen, Joan Paterson, Shirley Hodgson, Tessa Homfray, Lucy Side, Louise Izatt, Alan Donaldson, Susan Tomkins, Patrick Morrison, Carole Brewer, Alex Henderson, Rosemarie Davidson, Victoria Murday, Jaqueline Cook, Neva Haites, Timothy Bishop, Eamonn Sheridan, Andrew Green, Christopher Marks, Sue Carpenter, Mary Broughton, Lynn Greenhalge, Mohnish Suri, John M. Starr, Ian Deary, Iva Kirac, Dujo Kovacevia, Lauri A. Aaltonen, Laura Renkonen-Sinisalo, Jukka Pekka Mecklin, Koichi Matsuda, Yusuke Nakamura, Yukinori Okada, Steven Gallinger, David J. Duggan, David Conti, Polly Newcomb, John Hopper, Mark A. Jenkins, Fredrick Schumacher, Graham Casey, Douglas Easton, Mitul Shah, Paul Pharoah, Annika Lindblom, Tao Liu, David Edler, Claes Lenander, Johan Dalén, Fredrik Hjern, Nils Lundqvist, Ulrik Lindforss, Lars Påhlman, Kennet Smedh, Anders Törnqvist, Jörn Holm, Martin Janson, Magnus Andersson, Susanne Ekelund, Louise Olsson, Christopher G. Smith, Hannah West, Jeremy P. Cheadle, Graham MacDonald, Leslie M. Samuel, Athar Ahmad, Philippa Corrie, Duncan Jodrell, Cheryl Palmer, Charles Wilson, Julie O'Hagan, David Smith, Ray McDermott, Janice Walshe, James Cassidy, Alec McDonald, Nazia Mohammed, Jeff White, Hosney Yosef, Oscar Breathnach, Liam Grogan, Robert Thomas, Martin Eatock, Paul Henry, Russell Houston, Patrick Johnston, Richard Wilson, Ian Geh, Falalu Danwata, Andrew Hindley, Shabbir Susnerwala, Chris Bradley, Andrew Conn, Anne Raine, Chris Twelves, Stephen Falk, Kirstin Hopkins, Saad Tahir, Amandeep Dhadda, Anthony Maraveyas, Joseph Sgouros, Mark Teo, Rizvana Ahmad, Susan Cleator, Antonia Creak, Charles Lowdell, Philippa Riddle, Kim Benstead, David Farrugia, Nicholas Reed, Stephen Shepherd, Edward Levine, Saifee Mullamitha, Mark Saunders, Juan Valle, Gregory Wilson, Adam Jones, Andrew Weaver, Peter I. Clark, Brain Haylock, Mussawar I. Iqbal, Arthur S. Myint, Sharon Beesley, Timothy Sevitt, Jonathan Nicoll, Francis Daniel, Victoria Ford, Toby Talbot, Mohammad Butt, Abdel Hamid, Paul MacK, Raj Roy, Richard Osborne, Fiona McKinna, Heidar Alsab, Devyanee Basu, Phillip Murray, Bruce Sizer, Faisal A. Azam, Rekha Neupane, Ashita Waterston, John Glaholm, Claire Blesing, Sarah Lowndes, Aruna Medisetti, Andrew Gaya, Martin Leslie, Nicholas Maisey, Paul Ross, Grainne Dunn, Omar Al-Salihi, Harpreet S. Wasan, Li Tee Tan, Jo Dent, Uschi Hofmann, Johnathan K. Joffe, Elizabeth Sherwin, Rabinder Soomal, Amitabha Chakrabarti, Shibu Joseph, Johannes Van Der Voet, Nicholas J. Wadd, David Wilson, Salim Anjarwalia, Julia Hall, Rob Hughes, Andrew Polychronis, John H. Scarffe, Mark Hill, Rodger D. James, Riyaz Shah, Jeffrey Summers, Andrew Hartley, Desmond Carney, John McCaffrey, Brano Bystricky, Seamus O'Reilly, Rajnish Gupta, Talib Al-Mishlab, Fiona Gidden, Richard O'Hara, Jill Stewart, Richard Ashford, Robert Glynne-Jones, Mark Harrison, Suzannah Mawdsley, Hilary Barlow, Mary Tighe, Julie Walther, Janet Neal, Charlotte Rees, John Bridgewater, Stephen Karp, Ursula McGovern, Philip J. Atherton, Hany El-Deeb, Craig MacMillan, Kinnari Patel, Eric Michael Bessell, Peter D. Dickinson, Vanessa Potter, Catherine Jephcott, Karen McAdam, Jessica Wrigley, Sethupathi Muthuramalingam, Anne O'Callaghan, Lucinda Melcher, Chiara Braconi, Ju Ian Geh, Dan Palmer, Priya Narayana, Neil Steven, Andres Gaya, Sarah Rudman, Prabir Chakraborti, Kay Kelly, Carol MacGregor, David Whillis, Alice Freebairn, James Gildersleve, Sahid Sharif, George Astras, Tamas Hickish, Darren Beech, Richard Ellis, Rajendra Kulkarni, K. Shankland, Richard Begent, Astrid Mayer, Timothy Meyer, Sandra Strauss, Viriginia Hall, Sanjay Raj, Ian Chau, David Cunningham, Alison Birtle, Ashoke Biswas, Marcus Wise, Sebastian Cummins, Sharadah Essapen, Gary Middleton, Claire Topham, Ruth Langley, Andrew Webb, Marie Wilkins, Timothy John Iveson, Colin Askill, John Wagstaff, Ashraf Azzabi, Adrian Bateman, Jan Prejbisz, David Tsang, Nasim Ali, Amanda Jones, Paul O'Neill, Christopher Cottrill, David Propper, Fiona Jane Lofts, James Kennedy, David A. Anthoney, Rachel Cooper, Adrian Crellin, Alan Melcher, Matthew Seymour, Christopher Baughan, Emma Alexander, John Crown, David Fennelly, Fawzi Adab, Selvaraj Giridharan, Ian Pedley, Kathryn Wright, Peter Bliss, Geoffrey Cogill, Nangi Lo, Elizabeth Toy, Daniel Hochhauser, Jonathan Ledermann, Alison Brewster, Timothy Maughan, Diana Mort, Somnath Mukherjee, Werner Dobrowsky, Paula Calvert, Gregory Leonard, Hugo Ford, Anne Margeret Moody, Sonia Goriah, Margeret Wilkins, Sally Clive, Lesley Dawson, Catriona McLean, Hamish Andrew Phillips, Kakumudi Gopi, Marjorie Tomlinson, Susan Clenton, Debra Furniss, Joanne Hornbuckle, Simon Pledge, Jonathan Wadsley, Mohammed Abbas, Ernest Marshall, Catherine Harper-Wynne, Anne Barnes, Satish Kumar, Vallipuram Vigneswaran, Simon Gollins, M. Genton, Geoff Sparrow, Catherine Bale, C. Fuller, Anna Mullard, Nicholas Stuart, Rachel Williams, MacCon Keane, Tim Maughen, Richard Adams, Ayman Madi, Elizabeth Hodgkinson, Penny Rogers, Malcolm Pope, Rick Kaplan, Angela Meade, Mahesh Parmar, Sarah Kenny, David Fisher, Lynda Harper, Jena Mitchell, Laura Nichols, Benjamin Sydes, Louise Clement, Edward Kay, Cheryl Courtney, Madalena Gallagher, Claire Murphy, Lindsay Thompson, Sarah Beall, Sharma Hassan, Richard Gracie, Gareth Griffiths, Malcolm Mason, Chris Parker, Robin Rudd, Patrick Johnson, Jeremy Whelan, John Northover, Julia Brown, Matti Aapro, Ronald Stout, Rachel Midgley, David J. Kerr, Harry Campbell, Ian P. Tomlinson, Richard S. Houlston

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

Original languageEnglish (US)
Pages (from-to)770-776
Number of pages7
JournalNature Genetics
Volume44
Issue number7
DOIs
StatePublished - Jul 2012
Externally publishedYes

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Colorectal Neoplasms
Genome-Wide Association Study
Meta-Analysis

ASJC Scopus subject areas

  • Genetics

Cite this

Dunlop, M. G., Dobbins, S. E., Farrington, S. M., Jones, A. M., Palles, C., Whiffin, N., ... Houlston, R. S. (2012). Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nature Genetics, 44(7), 770-776. https://doi.org/10.1038/ng.2293

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. / Dunlop, Malcolm G.; Dobbins, Sara E.; Farrington, Susan Mary; Jones, Angela M.; Palles, Claire; Whiffin, Nicola; Tenesa, Albert; Spain, Sarah; Broderick, Peter; Ooi, Li Yin; Domingo, Enric; Smillie, Claire; Henrion, Marc; Frampton, Matthew; Martin, Lynn; Grimes, Graeme; Gorman, Maggie; Semple, Colin; Ma, Yusanne P.; Barclay, Ella; Prendergast, James; Cazier, Jean Baptiste; Olver, Bianca; Penegar, Steven; Lubbe, Steven; Chander, Ian; Carvajal-Carmona, Luis; Ballereau, Stephane; Lloyd, Amy; Vijayakrishnan, Jayaram; Zgaga, Lina; Rudan, Igor; Theodoratou, Evropi; Thomas, Huw; Maher, Eamonn; Evans, Gareth; Walker, Lisa; Halliday, Dorothy; Lucassen, Anneke; Paterson, Joan; Hodgson, Shirley; Homfray, Tessa; Side, Lucy; Izatt, Louise; Donaldson, Alan; Tomkins, Susan; Morrison, Patrick; Brewer, Carole; Henderson, Alex; Davidson, Rosemarie; Murday, Victoria; Cook, Jaqueline; Haites, Neva; Bishop, Timothy; Sheridan, Eamonn; Green, Andrew; Marks, Christopher; Carpenter, Sue; Broughton, Mary; Greenhalge, Lynn; Suri, Mohnish; Starr, John M.; Deary, Ian; Kirac, Iva; Kovacevia, Dujo; Aaltonen, Lauri A.; Renkonen-Sinisalo, Laura; Mecklin, Jukka Pekka; Matsuda, Koichi; Nakamura, Yusuke; Okada, Yukinori; Gallinger, Steven; Duggan, David J.; Conti, David; Newcomb, Polly; Hopper, John; Jenkins, Mark A.; Schumacher, Fredrick; Casey, Graham; Easton, Douglas; Shah, Mitul; Pharoah, Paul; Lindblom, Annika; Liu, Tao; Edler, David; Lenander, Claes; Dalén, Johan; Hjern, Fredrik; Lundqvist, Nils; Lindforss, Ulrik; Påhlman, Lars; Smedh, Kennet; Törnqvist, Anders; Holm, Jörn; Janson, Martin; Andersson, Magnus; Ekelund, Susanne; Olsson, Louise; Smith, Christopher G.; West, Hannah; Cheadle, Jeremy P.; MacDonald, Graham; Samuel, Leslie M.; Ahmad, Athar; Corrie, Philippa; Jodrell, Duncan; Palmer, Cheryl; Wilson, Charles; O'Hagan, Julie; Smith, David; McDermott, Ray; Walshe, Janice; Cassidy, James; McDonald, Alec; Mohammed, Nazia; White, Jeff; Yosef, Hosney; Breathnach, Oscar; Grogan, Liam; Thomas, Robert; Eatock, Martin; Henry, Paul; Houston, Russell; Johnston, Patrick; Wilson, Richard; Geh, Ian; Danwata, Falalu; Hindley, Andrew; Susnerwala, Shabbir; Bradley, Chris; Conn, Andrew; Raine, Anne; Twelves, Chris; Falk, Stephen; Hopkins, Kirstin; Tahir, Saad; Dhadda, Amandeep; Maraveyas, Anthony; Sgouros, Joseph; Teo, Mark; Ahmad, Rizvana; Cleator, Susan; Creak, Antonia; Lowdell, Charles; Riddle, Philippa; Benstead, Kim; Farrugia, David; Reed, Nicholas; Shepherd, Stephen; Levine, Edward; Mullamitha, Saifee; Saunders, Mark; Valle, Juan; Wilson, Gregory; Jones, Adam; Weaver, Andrew; Clark, Peter I.; Haylock, Brain; Iqbal, Mussawar I.; Myint, Arthur S.; Beesley, Sharon; Sevitt, Timothy; Nicoll, Jonathan; Daniel, Francis; Ford, Victoria; Talbot, Toby; Butt, Mohammad; Hamid, Abdel; MacK, Paul; Roy, Raj; Osborne, Richard; McKinna, Fiona; Alsab, Heidar; Basu, Devyanee; Murray, Phillip; Sizer, Bruce; Azam, Faisal A.; Neupane, Rekha; Waterston, Ashita; Glaholm, John; Blesing, Claire; Lowndes, Sarah; Medisetti, Aruna; Gaya, Andrew; Leslie, Martin; Maisey, Nicholas; Ross, Paul; Dunn, Grainne; Al-Salihi, Omar; Wasan, Harpreet S.; Tan, Li Tee; Dent, Jo; Hofmann, Uschi; Joffe, Johnathan K.; Sherwin, Elizabeth; Soomal, Rabinder; Chakrabarti, Amitabha; Joseph, Shibu; Van Der Voet, Johannes; Wadd, Nicholas J.; Wilson, David; Anjarwalia, Salim; Hall, Julia; Hughes, Rob; Polychronis, Andrew; Scarffe, John H.; Hill, Mark; James, Rodger D.; Shah, Riyaz; Summers, Jeffrey; Hartley, Andrew; Carney, Desmond; McCaffrey, John; Bystricky, Brano; O'Reilly, Seamus; Gupta, Rajnish; Al-Mishlab, Talib; Gidden, Fiona; O'Hara, Richard; Stewart, Jill; Ashford, Richard; Glynne-Jones, Robert; Harrison, Mark; Mawdsley, Suzannah; Barlow, Hilary; Tighe, Mary; Walther, Julie; Neal, Janet; Rees, Charlotte; Bridgewater, John; Karp, Stephen; McGovern, Ursula; Atherton, Philip J.; El-Deeb, Hany; MacMillan, Craig; Patel, Kinnari; Bessell, Eric Michael; Dickinson, Peter D.; Potter, Vanessa; Jephcott, Catherine; McAdam, Karen; Wrigley, Jessica; Muthuramalingam, Sethupathi; O'Callaghan, Anne; Melcher, Lucinda; Braconi, Chiara; Geh, Ju Ian; Palmer, Dan; Narayana, Priya; Steven, Neil; Gaya, Andres; Rudman, Sarah; Chakraborti, Prabir; Kelly, Kay; MacGregor, Carol; Whillis, David; Freebairn, Alice; Gildersleve, James; Sharif, Sahid; Astras, George; Hickish, Tamas; Beech, Darren; Ellis, Richard; Kulkarni, Rajendra; Shankland, K.; Begent, Richard; Mayer, Astrid; Meyer, Timothy; Strauss, Sandra; Hall, Viriginia; Raj, Sanjay; Chau, Ian; Cunningham, David; Birtle, Alison; Biswas, Ashoke; Wise, Marcus; Cummins, Sebastian; Essapen, Sharadah; Middleton, Gary; Topham, Claire; Langley, Ruth; Webb, Andrew; Wilkins, Marie; Iveson, Timothy John; Askill, Colin; Wagstaff, John; Azzabi, Ashraf; Bateman, Adrian; Prejbisz, Jan; Tsang, David; Ali, Nasim; Jones, Amanda; O'Neill, Paul; Cottrill, Christopher; Propper, David; Lofts, Fiona Jane; Kennedy, James; Anthoney, David A.; Cooper, Rachel; Crellin, Adrian; Melcher, Alan; Seymour, Matthew; Baughan, Christopher; Alexander, Emma; Crown, John; Fennelly, David; Adab, Fawzi; Giridharan, Selvaraj; Pedley, Ian; Wright, Kathryn; Bliss, Peter; Cogill, Geoffrey; Lo, Nangi; Toy, Elizabeth; Hochhauser, Daniel; Ledermann, Jonathan; Brewster, Alison; Maughan, Timothy; Mort, Diana; Mukherjee, Somnath; Dobrowsky, Werner; Calvert, Paula; Leonard, Gregory; Ford, Hugo; Moody, Anne Margeret; Goriah, Sonia; Wilkins, Margeret; Clive, Sally; Dawson, Lesley; McLean, Catriona; Phillips, Hamish Andrew; Gopi, Kakumudi; Tomlinson, Marjorie; Clenton, Susan; Furniss, Debra; Hornbuckle, Joanne; Pledge, Simon; Wadsley, Jonathan; Abbas, Mohammed; Marshall, Ernest; Harper-Wynne, Catherine; Barnes, Anne; Kumar, Satish; Vigneswaran, Vallipuram; Gollins, Simon; Genton, M.; Sparrow, Geoff; Bale, Catherine; Fuller, C.; Mullard, Anna; Stuart, Nicholas; Williams, Rachel; Keane, MacCon; Maughen, Tim; Adams, Richard; Madi, Ayman; Hodgkinson, Elizabeth; Rogers, Penny; Pope, Malcolm; Kaplan, Rick; Meade, Angela; Parmar, Mahesh; Kenny, Sarah; Fisher, David; Harper, Lynda; Mitchell, Jena; Nichols, Laura; Sydes, Benjamin; Clement, Louise; Kay, Edward; Courtney, Cheryl; Gallagher, Madalena; Murphy, Claire; Thompson, Lindsay; Beall, Sarah; Hassan, Sharma; Gracie, Richard; Griffiths, Gareth; Mason, Malcolm; Parker, Chris; Rudd, Robin; Johnson, Patrick; Whelan, Jeremy; Northover, John; Brown, Julia; Aapro, Matti; Stout, Ronald; Midgley, Rachel; Kerr, David J.; Campbell, Harry; Tomlinson, Ian P.; Houlston, Richard S.

In: Nature Genetics, Vol. 44, No. 7, 07.2012, p. 770-776.

Research output: Contribution to journalArticle

Dunlop, MG, Dobbins, SE, Farrington, SM, Jones, AM, Palles, C, Whiffin, N, Tenesa, A, Spain, S, Broderick, P, Ooi, LY, Domingo, E, Smillie, C, Henrion, M, Frampton, M, Martin, L, Grimes, G, Gorman, M, Semple, C, Ma, YP, Barclay, E, Prendergast, J, Cazier, JB, Olver, B, Penegar, S, Lubbe, S, Chander, I, Carvajal-Carmona, L, Ballereau, S, Lloyd, A, Vijayakrishnan, J, Zgaga, L, Rudan, I, Theodoratou, E, Thomas, H, Maher, E, Evans, G, Walker, L, Halliday, D, Lucassen, A, Paterson, J, Hodgson, S, Homfray, T, Side, L, Izatt, L, Donaldson, A, Tomkins, S, Morrison, P, Brewer, C, Henderson, A, Davidson, R, Murday, V, Cook, J, Haites, N, Bishop, T, Sheridan, E, Green, A, Marks, C, Carpenter, S, Broughton, M, Greenhalge, L, Suri, M, Starr, JM, Deary, I, Kirac, I, Kovacevia, D, Aaltonen, LA, Renkonen-Sinisalo, L, Mecklin, JP, Matsuda, K, Nakamura, Y, Okada, Y, Gallinger, S, Duggan, DJ, Conti, D, Newcomb, P, Hopper, J, Jenkins, MA, Schumacher, F, Casey, G, Easton, D, Shah, M, Pharoah, P, Lindblom, A, Liu, T, Edler, D, Lenander, C, Dalén, J, Hjern, F, Lundqvist, N, Lindforss, U, Påhlman, L, Smedh, K, Törnqvist, A, Holm, J, Janson, M, Andersson, M, Ekelund, S, Olsson, L, Smith, CG, West, H, Cheadle, JP, MacDonald, G, Samuel, LM, Ahmad, A, Corrie, P, Jodrell, D, Palmer, C, Wilson, C, O'Hagan, J, Smith, D, McDermott, R, Walshe, J, Cassidy, J, McDonald, A, Mohammed, N, White, J, Yosef, H, Breathnach, O, Grogan, L, Thomas, R, Eatock, M, Henry, P, Houston, R, Johnston, P, Wilson, R, Geh, I, Danwata, F, Hindley, A, Susnerwala, S, Bradley, C, Conn, A, Raine, A, Twelves, C, Falk, S, Hopkins, K, Tahir, S, Dhadda, A, Maraveyas, A, Sgouros, J, Teo, M, Ahmad, R, Cleator, S, Creak, A, Lowdell, C, Riddle, P, Benstead, K, Farrugia, D, Reed, N, Shepherd, S, Levine, E, Mullamitha, S, Saunders, M, Valle, J, Wilson, G, Jones, A, Weaver, A, Clark, PI, Haylock, B, Iqbal, MI, Myint, AS, Beesley, S, Sevitt, T, Nicoll, J, Daniel, F, Ford, V, Talbot, T, Butt, M, Hamid, A, MacK, P, Roy, R, Osborne, R, McKinna, F, Alsab, H, Basu, D, Murray, P, Sizer, B, Azam, FA, Neupane, R, Waterston, A, Glaholm, J, Blesing, C, Lowndes, S, Medisetti, A, Gaya, A, Leslie, M, Maisey, N, Ross, P, Dunn, G, Al-Salihi, O, Wasan, HS, Tan, LT, Dent, J, Hofmann, U, Joffe, JK, Sherwin, E, Soomal, R, Chakrabarti, A, Joseph, S, Van Der Voet, J, Wadd, NJ, Wilson, D, Anjarwalia, S, Hall, J, Hughes, R, Polychronis, A, Scarffe, JH, Hill, M, James, RD, Shah, R, Summers, J, Hartley, A, Carney, D, McCaffrey, J, Bystricky, B, O'Reilly, S, Gupta, R, Al-Mishlab, T, Gidden, F, O'Hara, R, Stewart, J, Ashford, R, Glynne-Jones, R, Harrison, M, Mawdsley, S, Barlow, H, Tighe, M, Walther, J, Neal, J, Rees, C, Bridgewater, J, Karp, S, McGovern, U, Atherton, PJ, El-Deeb, H, MacMillan, C, Patel, K, Bessell, EM, Dickinson, PD, Potter, V, Jephcott, C, McAdam, K, Wrigley, J, Muthuramalingam, S, O'Callaghan, A, Melcher, L, Braconi, C, Geh, JI, Palmer, D, Narayana, P, Steven, N, Gaya, A, Rudman, S, Chakraborti, P, Kelly, K, MacGregor, C, Whillis, D, Freebairn, A, Gildersleve, J, Sharif, S, Astras, G, Hickish, T, Beech, D, Ellis, R, Kulkarni, R, Shankland, K, Begent, R, Mayer, A, Meyer, T, Strauss, S, Hall, V, Raj, S, Chau, I, Cunningham, D, Birtle, A, Biswas, A, Wise, M, Cummins, S, Essapen, S, Middleton, G, Topham, C, Langley, R, Webb, A, Wilkins, M, Iveson, TJ, Askill, C, Wagstaff, J, Azzabi, A, Bateman, A, Prejbisz, J, Tsang, D, Ali, N, Jones, A, O'Neill, P, Cottrill, C, Propper, D, Lofts, FJ, Kennedy, J, Anthoney, DA, Cooper, R, Crellin, A, Melcher, A, Seymour, M, Baughan, C, Alexander, E, Crown, J, Fennelly, D, Adab, F, Giridharan, S, Pedley, I, Wright, K, Bliss, P, Cogill, G, Lo, N, Toy, E, Hochhauser, D, Ledermann, J, Brewster, A, Maughan, T, Mort, D, Mukherjee, S, Dobrowsky, W, Calvert, P, Leonard, G, Ford, H, Moody, AM, Goriah, S, Wilkins, M, Clive, S, Dawson, L, McLean, C, Phillips, HA, Gopi, K, Tomlinson, M, Clenton, S, Furniss, D, Hornbuckle, J, Pledge, S, Wadsley, J, Abbas, M, Marshall, E, Harper-Wynne, C, Barnes, A, Kumar, S, Vigneswaran, V, Gollins, S, Genton, M, Sparrow, G, Bale, C, Fuller, C, Mullard, A, Stuart, N, Williams, R, Keane, M, Maughen, T, Adams, R, Madi, A, Hodgkinson, E, Rogers, P, Pope, M, Kaplan, R, Meade, A, Parmar, M, Kenny, S, Fisher, D, Harper, L, Mitchell, J, Nichols, L, Sydes, B, Clement, L, Kay, E, Courtney, C, Gallagher, M, Murphy, C, Thompson, L, Beall, S, Hassan, S, Gracie, R, Griffiths, G, Mason, M, Parker, C, Rudd, R, Johnson, P, Whelan, J, Northover, J, Brown, J, Aapro, M, Stout, R, Midgley, R, Kerr, DJ, Campbell, H, Tomlinson, IP & Houlston, RS 2012, 'Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk', Nature Genetics, vol. 44, no. 7, pp. 770-776. https://doi.org/10.1038/ng.2293
Dunlop MG, Dobbins SE, Farrington SM, Jones AM, Palles C, Whiffin N et al. Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nature Genetics. 2012 Jul;44(7):770-776. https://doi.org/10.1038/ng.2293
Dunlop, Malcolm G. ; Dobbins, Sara E. ; Farrington, Susan Mary ; Jones, Angela M. ; Palles, Claire ; Whiffin, Nicola ; Tenesa, Albert ; Spain, Sarah ; Broderick, Peter ; Ooi, Li Yin ; Domingo, Enric ; Smillie, Claire ; Henrion, Marc ; Frampton, Matthew ; Martin, Lynn ; Grimes, Graeme ; Gorman, Maggie ; Semple, Colin ; Ma, Yusanne P. ; Barclay, Ella ; Prendergast, James ; Cazier, Jean Baptiste ; Olver, Bianca ; Penegar, Steven ; Lubbe, Steven ; Chander, Ian ; Carvajal-Carmona, Luis ; Ballereau, Stephane ; Lloyd, Amy ; Vijayakrishnan, Jayaram ; Zgaga, Lina ; Rudan, Igor ; Theodoratou, Evropi ; Thomas, Huw ; Maher, Eamonn ; Evans, Gareth ; Walker, Lisa ; Halliday, Dorothy ; Lucassen, Anneke ; Paterson, Joan ; Hodgson, Shirley ; Homfray, Tessa ; Side, Lucy ; Izatt, Louise ; Donaldson, Alan ; Tomkins, Susan ; Morrison, Patrick ; Brewer, Carole ; Henderson, Alex ; Davidson, Rosemarie ; Murday, Victoria ; Cook, Jaqueline ; Haites, Neva ; Bishop, Timothy ; Sheridan, Eamonn ; Green, Andrew ; Marks, Christopher ; Carpenter, Sue ; Broughton, Mary ; Greenhalge, Lynn ; Suri, Mohnish ; Starr, John M. ; Deary, Ian ; Kirac, Iva ; Kovacevia, Dujo ; Aaltonen, Lauri A. ; Renkonen-Sinisalo, Laura ; Mecklin, Jukka Pekka ; Matsuda, Koichi ; Nakamura, Yusuke ; Okada, Yukinori ; Gallinger, Steven ; Duggan, David J. ; Conti, David ; Newcomb, Polly ; Hopper, John ; Jenkins, Mark A. ; Schumacher, Fredrick ; Casey, Graham ; Easton, Douglas ; Shah, Mitul ; Pharoah, Paul ; Lindblom, Annika ; Liu, Tao ; Edler, David ; Lenander, Claes ; Dalén, Johan ; Hjern, Fredrik ; Lundqvist, Nils ; Lindforss, Ulrik ; Påhlman, Lars ; Smedh, Kennet ; Törnqvist, Anders ; Holm, Jörn ; Janson, Martin ; Andersson, Magnus ; Ekelund, Susanne ; Olsson, Louise ; Smith, Christopher G. ; West, Hannah ; Cheadle, Jeremy P. ; MacDonald, Graham ; Samuel, Leslie M. ; Ahmad, Athar ; Corrie, Philippa ; Jodrell, Duncan ; Palmer, Cheryl ; Wilson, Charles ; O'Hagan, Julie ; Smith, David ; McDermott, Ray ; Walshe, Janice ; Cassidy, James ; McDonald, Alec ; Mohammed, Nazia ; White, Jeff ; Yosef, Hosney ; Breathnach, Oscar ; Grogan, Liam ; Thomas, Robert ; Eatock, Martin ; Henry, Paul ; Houston, Russell ; Johnston, Patrick ; Wilson, Richard ; Geh, Ian ; Danwata, Falalu ; Hindley, Andrew ; Susnerwala, Shabbir ; Bradley, Chris ; Conn, Andrew ; Raine, Anne ; Twelves, Chris ; Falk, Stephen ; Hopkins, Kirstin ; Tahir, Saad ; Dhadda, Amandeep ; Maraveyas, Anthony ; Sgouros, Joseph ; Teo, Mark ; Ahmad, Rizvana ; Cleator, Susan ; Creak, Antonia ; Lowdell, Charles ; Riddle, Philippa ; Benstead, Kim ; Farrugia, David ; Reed, Nicholas ; Shepherd, Stephen ; Levine, Edward ; Mullamitha, Saifee ; Saunders, Mark ; Valle, Juan ; Wilson, Gregory ; Jones, Adam ; Weaver, Andrew ; Clark, Peter I. ; Haylock, Brain ; Iqbal, Mussawar I. ; Myint, Arthur S. ; Beesley, Sharon ; Sevitt, Timothy ; Nicoll, Jonathan ; Daniel, Francis ; Ford, Victoria ; Talbot, Toby ; Butt, Mohammad ; Hamid, Abdel ; MacK, Paul ; Roy, Raj ; Osborne, Richard ; McKinna, Fiona ; Alsab, Heidar ; Basu, Devyanee ; Murray, Phillip ; Sizer, Bruce ; Azam, Faisal A. ; Neupane, Rekha ; Waterston, Ashita ; Glaholm, John ; Blesing, Claire ; Lowndes, Sarah ; Medisetti, Aruna ; Gaya, Andrew ; Leslie, Martin ; Maisey, Nicholas ; Ross, Paul ; Dunn, Grainne ; Al-Salihi, Omar ; Wasan, Harpreet S. ; Tan, Li Tee ; Dent, Jo ; Hofmann, Uschi ; Joffe, Johnathan K. ; Sherwin, Elizabeth ; Soomal, Rabinder ; Chakrabarti, Amitabha ; Joseph, Shibu ; Van Der Voet, Johannes ; Wadd, Nicholas J. ; Wilson, David ; Anjarwalia, Salim ; Hall, Julia ; Hughes, Rob ; Polychronis, Andrew ; Scarffe, John H. ; Hill, Mark ; James, Rodger D. ; Shah, Riyaz ; Summers, Jeffrey ; Hartley, Andrew ; Carney, Desmond ; McCaffrey, John ; Bystricky, Brano ; O'Reilly, Seamus ; Gupta, Rajnish ; Al-Mishlab, Talib ; Gidden, Fiona ; O'Hara, Richard ; Stewart, Jill ; Ashford, Richard ; Glynne-Jones, Robert ; Harrison, Mark ; Mawdsley, Suzannah ; Barlow, Hilary ; Tighe, Mary ; Walther, Julie ; Neal, Janet ; Rees, Charlotte ; Bridgewater, John ; Karp, Stephen ; McGovern, Ursula ; Atherton, Philip J. ; El-Deeb, Hany ; MacMillan, Craig ; Patel, Kinnari ; Bessell, Eric Michael ; Dickinson, Peter D. ; Potter, Vanessa ; Jephcott, Catherine ; McAdam, Karen ; Wrigley, Jessica ; Muthuramalingam, Sethupathi ; O'Callaghan, Anne ; Melcher, Lucinda ; Braconi, Chiara ; Geh, Ju Ian ; Palmer, Dan ; Narayana, Priya ; Steven, Neil ; Gaya, Andres ; Rudman, Sarah ; Chakraborti, Prabir ; Kelly, Kay ; MacGregor, Carol ; Whillis, David ; Freebairn, Alice ; Gildersleve, James ; Sharif, Sahid ; Astras, George ; Hickish, Tamas ; Beech, Darren ; Ellis, Richard ; Kulkarni, Rajendra ; Shankland, K. ; Begent, Richard ; Mayer, Astrid ; Meyer, Timothy ; Strauss, Sandra ; Hall, Viriginia ; Raj, Sanjay ; Chau, Ian ; Cunningham, David ; Birtle, Alison ; Biswas, Ashoke ; Wise, Marcus ; Cummins, Sebastian ; Essapen, Sharadah ; Middleton, Gary ; Topham, Claire ; Langley, Ruth ; Webb, Andrew ; Wilkins, Marie ; Iveson, Timothy John ; Askill, Colin ; Wagstaff, John ; Azzabi, Ashraf ; Bateman, Adrian ; Prejbisz, Jan ; Tsang, David ; Ali, Nasim ; Jones, Amanda ; O'Neill, Paul ; Cottrill, Christopher ; Propper, David ; Lofts, Fiona Jane ; Kennedy, James ; Anthoney, David A. ; Cooper, Rachel ; Crellin, Adrian ; Melcher, Alan ; Seymour, Matthew ; Baughan, Christopher ; Alexander, Emma ; Crown, John ; Fennelly, David ; Adab, Fawzi ; Giridharan, Selvaraj ; Pedley, Ian ; Wright, Kathryn ; Bliss, Peter ; Cogill, Geoffrey ; Lo, Nangi ; Toy, Elizabeth ; Hochhauser, Daniel ; Ledermann, Jonathan ; Brewster, Alison ; Maughan, Timothy ; Mort, Diana ; Mukherjee, Somnath ; Dobrowsky, Werner ; Calvert, Paula ; Leonard, Gregory ; Ford, Hugo ; Moody, Anne Margeret ; Goriah, Sonia ; Wilkins, Margeret ; Clive, Sally ; Dawson, Lesley ; McLean, Catriona ; Phillips, Hamish Andrew ; Gopi, Kakumudi ; Tomlinson, Marjorie ; Clenton, Susan ; Furniss, Debra ; Hornbuckle, Joanne ; Pledge, Simon ; Wadsley, Jonathan ; Abbas, Mohammed ; Marshall, Ernest ; Harper-Wynne, Catherine ; Barnes, Anne ; Kumar, Satish ; Vigneswaran, Vallipuram ; Gollins, Simon ; Genton, M. ; Sparrow, Geoff ; Bale, Catherine ; Fuller, C. ; Mullard, Anna ; Stuart, Nicholas ; Williams, Rachel ; Keane, MacCon ; Maughen, Tim ; Adams, Richard ; Madi, Ayman ; Hodgkinson, Elizabeth ; Rogers, Penny ; Pope, Malcolm ; Kaplan, Rick ; Meade, Angela ; Parmar, Mahesh ; Kenny, Sarah ; Fisher, David ; Harper, Lynda ; Mitchell, Jena ; Nichols, Laura ; Sydes, Benjamin ; Clement, Louise ; Kay, Edward ; Courtney, Cheryl ; Gallagher, Madalena ; Murphy, Claire ; Thompson, Lindsay ; Beall, Sarah ; Hassan, Sharma ; Gracie, Richard ; Griffiths, Gareth ; Mason, Malcolm ; Parker, Chris ; Rudd, Robin ; Johnson, Patrick ; Whelan, Jeremy ; Northover, John ; Brown, Julia ; Aapro, Matti ; Stout, Ronald ; Midgley, Rachel ; Kerr, David J. ; Campbell, Harry ; Tomlinson, Ian P. ; Houlston, Richard S. / Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. In: Nature Genetics. 2012 ; Vol. 44, No. 7. pp. 770-776.
@article{928debd8a8a6466bb9c2d1bccfe6e136,
title = "Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk",
abstract = "We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.",
author = "Dunlop, {Malcolm G.} and Dobbins, {Sara E.} and Farrington, {Susan Mary} and Jones, {Angela M.} and Claire Palles and Nicola Whiffin and Albert Tenesa and Sarah Spain and Peter Broderick and Ooi, {Li Yin} and Enric Domingo and Claire Smillie and Marc Henrion and Matthew Frampton and Lynn Martin and Graeme Grimes and Maggie Gorman and Colin Semple and Ma, {Yusanne P.} and Ella Barclay and James Prendergast and Cazier, {Jean Baptiste} and Bianca Olver and Steven Penegar and Steven Lubbe and Ian Chander and Luis Carvajal-Carmona and Stephane Ballereau and Amy Lloyd and Jayaram Vijayakrishnan and Lina Zgaga and Igor Rudan and Evropi Theodoratou and Huw Thomas and Eamonn Maher and Gareth Evans and Lisa Walker and Dorothy Halliday and Anneke Lucassen and Joan Paterson and Shirley Hodgson and Tessa Homfray and Lucy Side and Louise Izatt and Alan Donaldson and Susan Tomkins and Patrick Morrison and Carole Brewer and Alex Henderson and Rosemarie Davidson and Victoria Murday and Jaqueline Cook and Neva Haites and Timothy Bishop and Eamonn Sheridan and Andrew Green and Christopher Marks and Sue Carpenter and Mary Broughton and Lynn Greenhalge and Mohnish Suri and Starr, {John M.} and Ian Deary and Iva Kirac and Dujo Kovacevia and Aaltonen, {Lauri A.} and Laura Renkonen-Sinisalo and Mecklin, {Jukka Pekka} and Koichi Matsuda and Yusuke Nakamura and Yukinori Okada and Steven Gallinger and Duggan, {David J.} and David Conti and Polly Newcomb and John Hopper and Jenkins, {Mark A.} and Fredrick Schumacher and Graham Casey and Douglas Easton and Mitul Shah and Paul Pharoah and Annika Lindblom and Tao Liu and David Edler and Claes Lenander and Johan Dal{\'e}n and Fredrik Hjern and Nils Lundqvist and Ulrik Lindforss and Lars P{\aa}hlman and Kennet Smedh and Anders T{\"o}rnqvist and J{\"o}rn Holm and Martin Janson and Magnus Andersson and Susanne Ekelund and Louise Olsson and Smith, {Christopher G.} and Hannah West and Cheadle, {Jeremy P.} and Graham MacDonald and Samuel, {Leslie M.} and Athar Ahmad and Philippa Corrie and Duncan Jodrell and Cheryl Palmer and Charles Wilson and Julie O'Hagan and David Smith and Ray McDermott and Janice Walshe and James Cassidy and Alec McDonald and Nazia Mohammed and Jeff White and Hosney Yosef and Oscar Breathnach and Liam Grogan and Robert Thomas and Martin Eatock and Paul Henry and Russell Houston and Patrick Johnston and Richard Wilson and Ian Geh and Falalu Danwata and Andrew Hindley and Shabbir Susnerwala and Chris Bradley and Andrew Conn and Anne Raine and Chris Twelves and Stephen Falk and Kirstin Hopkins and Saad Tahir and Amandeep Dhadda and Anthony Maraveyas and Joseph Sgouros and Mark Teo and Rizvana Ahmad and Susan Cleator and Antonia Creak and Charles Lowdell and Philippa Riddle and Kim Benstead and David Farrugia and Nicholas Reed and Stephen Shepherd and Edward Levine and Saifee Mullamitha and Mark Saunders and Juan Valle and Gregory Wilson and Adam Jones and Andrew Weaver and Clark, {Peter I.} and Brain Haylock and Iqbal, {Mussawar I.} and Myint, {Arthur S.} and Sharon Beesley and Timothy Sevitt and Jonathan Nicoll and Francis Daniel and Victoria Ford and Toby Talbot and Mohammad Butt and Abdel Hamid and Paul MacK and Raj Roy and Richard Osborne and Fiona McKinna and Heidar Alsab and Devyanee Basu and Phillip Murray and Bruce Sizer and Azam, {Faisal A.} and Rekha Neupane and Ashita Waterston and John Glaholm and Claire Blesing and Sarah Lowndes and Aruna Medisetti and Andrew Gaya and Martin Leslie and Nicholas Maisey and Paul Ross and Grainne Dunn and Omar Al-Salihi and Wasan, {Harpreet S.} and Tan, {Li Tee} and Jo Dent and Uschi Hofmann and Joffe, {Johnathan K.} and Elizabeth Sherwin and Rabinder Soomal and Amitabha Chakrabarti and Shibu Joseph and {Van Der Voet}, Johannes and Wadd, {Nicholas J.} and David Wilson and Salim Anjarwalia and Julia Hall and Rob Hughes and Andrew Polychronis and Scarffe, {John H.} and Mark Hill and James, {Rodger D.} and Riyaz Shah and Jeffrey Summers and Andrew Hartley and Desmond Carney and John McCaffrey and Brano Bystricky and Seamus O'Reilly and Rajnish Gupta and Talib Al-Mishlab and Fiona Gidden and Richard O'Hara and Jill Stewart and Richard Ashford and Robert Glynne-Jones and Mark Harrison and Suzannah Mawdsley and Hilary Barlow and Mary Tighe and Julie Walther and Janet Neal and Charlotte Rees and John Bridgewater and Stephen Karp and Ursula McGovern and Atherton, {Philip J.} and Hany El-Deeb and Craig MacMillan and Kinnari Patel and Bessell, {Eric Michael} and Dickinson, {Peter D.} and Vanessa Potter and Catherine Jephcott and Karen McAdam and Jessica Wrigley and Sethupathi Muthuramalingam and Anne O'Callaghan and Lucinda Melcher and Chiara Braconi and Geh, {Ju Ian} and Dan Palmer and Priya Narayana and Neil Steven and Andres Gaya and Sarah Rudman and Prabir Chakraborti and Kay Kelly and Carol MacGregor and David Whillis and Alice Freebairn and James Gildersleve and Sahid Sharif and George Astras and Tamas Hickish and Darren Beech and Richard Ellis and Rajendra Kulkarni and K. Shankland and Richard Begent and Astrid Mayer and Timothy Meyer and Sandra Strauss and Viriginia Hall and Sanjay Raj and Ian Chau and David Cunningham and Alison Birtle and Ashoke Biswas and Marcus Wise and Sebastian Cummins and Sharadah Essapen and Gary Middleton and Claire Topham and Ruth Langley and Andrew Webb and Marie Wilkins and Iveson, {Timothy John} and Colin Askill and John Wagstaff and Ashraf Azzabi and Adrian Bateman and Jan Prejbisz and David Tsang and Nasim Ali and Amanda Jones and Paul O'Neill and Christopher Cottrill and David Propper and Lofts, {Fiona Jane} and James Kennedy and Anthoney, {David A.} and Rachel Cooper and Adrian Crellin and Alan Melcher and Matthew Seymour and Christopher Baughan and Emma Alexander and John Crown and David Fennelly and Fawzi Adab and Selvaraj Giridharan and Ian Pedley and Kathryn Wright and Peter Bliss and Geoffrey Cogill and Nangi Lo and Elizabeth Toy and Daniel Hochhauser and Jonathan Ledermann and Alison Brewster and Timothy Maughan and Diana Mort and Somnath Mukherjee and Werner Dobrowsky and Paula Calvert and Gregory Leonard and Hugo Ford and Moody, {Anne Margeret} and Sonia Goriah and Margeret Wilkins and Sally Clive and Lesley Dawson and Catriona McLean and Phillips, {Hamish Andrew} and Kakumudi Gopi and Marjorie Tomlinson and Susan Clenton and Debra Furniss and Joanne Hornbuckle and Simon Pledge and Jonathan Wadsley and Mohammed Abbas and Ernest Marshall and Catherine Harper-Wynne and Anne Barnes and Satish Kumar and Vallipuram Vigneswaran and Simon Gollins and M. Genton and Geoff Sparrow and Catherine Bale and C. Fuller and Anna Mullard and Nicholas Stuart and Rachel Williams and MacCon Keane and Tim Maughen and Richard Adams and Ayman Madi and Elizabeth Hodgkinson and Penny Rogers and Malcolm Pope and Rick Kaplan and Angela Meade and Mahesh Parmar and Sarah Kenny and David Fisher and Lynda Harper and Jena Mitchell and Laura Nichols and Benjamin Sydes and Louise Clement and Edward Kay and Cheryl Courtney and Madalena Gallagher and Claire Murphy and Lindsay Thompson and Sarah Beall and Sharma Hassan and Richard Gracie and Gareth Griffiths and Malcolm Mason and Chris Parker and Robin Rudd and Patrick Johnson and Jeremy Whelan and John Northover and Julia Brown and Matti Aapro and Ronald Stout and Rachel Midgley and Kerr, {David J.} and Harry Campbell and Tomlinson, {Ian P.} and Houlston, {Richard S.}",
year = "2012",
month = "7",
doi = "10.1038/ng.2293",
language = "English (US)",
volume = "44",
pages = "770--776",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

AU - Dunlop, Malcolm G.

AU - Dobbins, Sara E.

AU - Farrington, Susan Mary

AU - Jones, Angela M.

AU - Palles, Claire

AU - Whiffin, Nicola

AU - Tenesa, Albert

AU - Spain, Sarah

AU - Broderick, Peter

AU - Ooi, Li Yin

AU - Domingo, Enric

AU - Smillie, Claire

AU - Henrion, Marc

AU - Frampton, Matthew

AU - Martin, Lynn

AU - Grimes, Graeme

AU - Gorman, Maggie

AU - Semple, Colin

AU - Ma, Yusanne P.

AU - Barclay, Ella

AU - Prendergast, James

AU - Cazier, Jean Baptiste

AU - Olver, Bianca

AU - Penegar, Steven

AU - Lubbe, Steven

AU - Chander, Ian

AU - Carvajal-Carmona, Luis

AU - Ballereau, Stephane

AU - Lloyd, Amy

AU - Vijayakrishnan, Jayaram

AU - Zgaga, Lina

AU - Rudan, Igor

AU - Theodoratou, Evropi

AU - Thomas, Huw

AU - Maher, Eamonn

AU - Evans, Gareth

AU - Walker, Lisa

AU - Halliday, Dorothy

AU - Lucassen, Anneke

AU - Paterson, Joan

AU - Hodgson, Shirley

AU - Homfray, Tessa

AU - Side, Lucy

AU - Izatt, Louise

AU - Donaldson, Alan

AU - Tomkins, Susan

AU - Morrison, Patrick

AU - Brewer, Carole

AU - Henderson, Alex

AU - Davidson, Rosemarie

AU - Murday, Victoria

AU - Cook, Jaqueline

AU - Haites, Neva

AU - Bishop, Timothy

AU - Sheridan, Eamonn

AU - Green, Andrew

AU - Marks, Christopher

AU - Carpenter, Sue

AU - Broughton, Mary

AU - Greenhalge, Lynn

AU - Suri, Mohnish

AU - Starr, John M.

AU - Deary, Ian

AU - Kirac, Iva

AU - Kovacevia, Dujo

AU - Aaltonen, Lauri A.

AU - Renkonen-Sinisalo, Laura

AU - Mecklin, Jukka Pekka

AU - Matsuda, Koichi

AU - Nakamura, Yusuke

AU - Okada, Yukinori

AU - Gallinger, Steven

AU - Duggan, David J.

AU - Conti, David

AU - Newcomb, Polly

AU - Hopper, John

AU - Jenkins, Mark A.

AU - Schumacher, Fredrick

AU - Casey, Graham

AU - Easton, Douglas

AU - Shah, Mitul

AU - Pharoah, Paul

AU - Lindblom, Annika

AU - Liu, Tao

AU - Edler, David

AU - Lenander, Claes

AU - Dalén, Johan

AU - Hjern, Fredrik

AU - Lundqvist, Nils

AU - Lindforss, Ulrik

AU - Påhlman, Lars

AU - Smedh, Kennet

AU - Törnqvist, Anders

AU - Holm, Jörn

AU - Janson, Martin

AU - Andersson, Magnus

AU - Ekelund, Susanne

AU - Olsson, Louise

AU - Smith, Christopher G.

AU - West, Hannah

AU - Cheadle, Jeremy P.

AU - MacDonald, Graham

AU - Samuel, Leslie M.

AU - Ahmad, Athar

AU - Corrie, Philippa

AU - Jodrell, Duncan

AU - Palmer, Cheryl

AU - Wilson, Charles

AU - O'Hagan, Julie

AU - Smith, David

AU - McDermott, Ray

AU - Walshe, Janice

AU - Cassidy, James

AU - McDonald, Alec

AU - Mohammed, Nazia

AU - White, Jeff

AU - Yosef, Hosney

AU - Breathnach, Oscar

AU - Grogan, Liam

AU - Thomas, Robert

AU - Eatock, Martin

AU - Henry, Paul

AU - Houston, Russell

AU - Johnston, Patrick

AU - Wilson, Richard

AU - Geh, Ian

AU - Danwata, Falalu

AU - Hindley, Andrew

AU - Susnerwala, Shabbir

AU - Bradley, Chris

AU - Conn, Andrew

AU - Raine, Anne

AU - Twelves, Chris

AU - Falk, Stephen

AU - Hopkins, Kirstin

AU - Tahir, Saad

AU - Dhadda, Amandeep

AU - Maraveyas, Anthony

AU - Sgouros, Joseph

AU - Teo, Mark

AU - Ahmad, Rizvana

AU - Cleator, Susan

AU - Creak, Antonia

AU - Lowdell, Charles

AU - Riddle, Philippa

AU - Benstead, Kim

AU - Farrugia, David

AU - Reed, Nicholas

AU - Shepherd, Stephen

AU - Levine, Edward

AU - Mullamitha, Saifee

AU - Saunders, Mark

AU - Valle, Juan

AU - Wilson, Gregory

AU - Jones, Adam

AU - Weaver, Andrew

AU - Clark, Peter I.

AU - Haylock, Brain

AU - Iqbal, Mussawar I.

AU - Myint, Arthur S.

AU - Beesley, Sharon

AU - Sevitt, Timothy

AU - Nicoll, Jonathan

AU - Daniel, Francis

AU - Ford, Victoria

AU - Talbot, Toby

AU - Butt, Mohammad

AU - Hamid, Abdel

AU - MacK, Paul

AU - Roy, Raj

AU - Osborne, Richard

AU - McKinna, Fiona

AU - Alsab, Heidar

AU - Basu, Devyanee

AU - Murray, Phillip

AU - Sizer, Bruce

AU - Azam, Faisal A.

AU - Neupane, Rekha

AU - Waterston, Ashita

AU - Glaholm, John

AU - Blesing, Claire

AU - Lowndes, Sarah

AU - Medisetti, Aruna

AU - Gaya, Andrew

AU - Leslie, Martin

AU - Maisey, Nicholas

AU - Ross, Paul

AU - Dunn, Grainne

AU - Al-Salihi, Omar

AU - Wasan, Harpreet S.

AU - Tan, Li Tee

AU - Dent, Jo

AU - Hofmann, Uschi

AU - Joffe, Johnathan K.

AU - Sherwin, Elizabeth

AU - Soomal, Rabinder

AU - Chakrabarti, Amitabha

AU - Joseph, Shibu

AU - Van Der Voet, Johannes

AU - Wadd, Nicholas J.

AU - Wilson, David

AU - Anjarwalia, Salim

AU - Hall, Julia

AU - Hughes, Rob

AU - Polychronis, Andrew

AU - Scarffe, John H.

AU - Hill, Mark

AU - James, Rodger D.

AU - Shah, Riyaz

AU - Summers, Jeffrey

AU - Hartley, Andrew

AU - Carney, Desmond

AU - McCaffrey, John

AU - Bystricky, Brano

AU - O'Reilly, Seamus

AU - Gupta, Rajnish

AU - Al-Mishlab, Talib

AU - Gidden, Fiona

AU - O'Hara, Richard

AU - Stewart, Jill

AU - Ashford, Richard

AU - Glynne-Jones, Robert

AU - Harrison, Mark

AU - Mawdsley, Suzannah

AU - Barlow, Hilary

AU - Tighe, Mary

AU - Walther, Julie

AU - Neal, Janet

AU - Rees, Charlotte

AU - Bridgewater, John

AU - Karp, Stephen

AU - McGovern, Ursula

AU - Atherton, Philip J.

AU - El-Deeb, Hany

AU - MacMillan, Craig

AU - Patel, Kinnari

AU - Bessell, Eric Michael

AU - Dickinson, Peter D.

AU - Potter, Vanessa

AU - Jephcott, Catherine

AU - McAdam, Karen

AU - Wrigley, Jessica

AU - Muthuramalingam, Sethupathi

AU - O'Callaghan, Anne

AU - Melcher, Lucinda

AU - Braconi, Chiara

AU - Geh, Ju Ian

AU - Palmer, Dan

AU - Narayana, Priya

AU - Steven, Neil

AU - Gaya, Andres

AU - Rudman, Sarah

AU - Chakraborti, Prabir

AU - Kelly, Kay

AU - MacGregor, Carol

AU - Whillis, David

AU - Freebairn, Alice

AU - Gildersleve, James

AU - Sharif, Sahid

AU - Astras, George

AU - Hickish, Tamas

AU - Beech, Darren

AU - Ellis, Richard

AU - Kulkarni, Rajendra

AU - Shankland, K.

AU - Begent, Richard

AU - Mayer, Astrid

AU - Meyer, Timothy

AU - Strauss, Sandra

AU - Hall, Viriginia

AU - Raj, Sanjay

AU - Chau, Ian

AU - Cunningham, David

AU - Birtle, Alison

AU - Biswas, Ashoke

AU - Wise, Marcus

AU - Cummins, Sebastian

AU - Essapen, Sharadah

AU - Middleton, Gary

AU - Topham, Claire

AU - Langley, Ruth

AU - Webb, Andrew

AU - Wilkins, Marie

AU - Iveson, Timothy John

AU - Askill, Colin

AU - Wagstaff, John

AU - Azzabi, Ashraf

AU - Bateman, Adrian

AU - Prejbisz, Jan

AU - Tsang, David

AU - Ali, Nasim

AU - Jones, Amanda

AU - O'Neill, Paul

AU - Cottrill, Christopher

AU - Propper, David

AU - Lofts, Fiona Jane

AU - Kennedy, James

AU - Anthoney, David A.

AU - Cooper, Rachel

AU - Crellin, Adrian

AU - Melcher, Alan

AU - Seymour, Matthew

AU - Baughan, Christopher

AU - Alexander, Emma

AU - Crown, John

AU - Fennelly, David

AU - Adab, Fawzi

AU - Giridharan, Selvaraj

AU - Pedley, Ian

AU - Wright, Kathryn

AU - Bliss, Peter

AU - Cogill, Geoffrey

AU - Lo, Nangi

AU - Toy, Elizabeth

AU - Hochhauser, Daniel

AU - Ledermann, Jonathan

AU - Brewster, Alison

AU - Maughan, Timothy

AU - Mort, Diana

AU - Mukherjee, Somnath

AU - Dobrowsky, Werner

AU - Calvert, Paula

AU - Leonard, Gregory

AU - Ford, Hugo

AU - Moody, Anne Margeret

AU - Goriah, Sonia

AU - Wilkins, Margeret

AU - Clive, Sally

AU - Dawson, Lesley

AU - McLean, Catriona

AU - Phillips, Hamish Andrew

AU - Gopi, Kakumudi

AU - Tomlinson, Marjorie

AU - Clenton, Susan

AU - Furniss, Debra

AU - Hornbuckle, Joanne

AU - Pledge, Simon

AU - Wadsley, Jonathan

AU - Abbas, Mohammed

AU - Marshall, Ernest

AU - Harper-Wynne, Catherine

AU - Barnes, Anne

AU - Kumar, Satish

AU - Vigneswaran, Vallipuram

AU - Gollins, Simon

AU - Genton, M.

AU - Sparrow, Geoff

AU - Bale, Catherine

AU - Fuller, C.

AU - Mullard, Anna

AU - Stuart, Nicholas

AU - Williams, Rachel

AU - Keane, MacCon

AU - Maughen, Tim

AU - Adams, Richard

AU - Madi, Ayman

AU - Hodgkinson, Elizabeth

AU - Rogers, Penny

AU - Pope, Malcolm

AU - Kaplan, Rick

AU - Meade, Angela

AU - Parmar, Mahesh

AU - Kenny, Sarah

AU - Fisher, David

AU - Harper, Lynda

AU - Mitchell, Jena

AU - Nichols, Laura

AU - Sydes, Benjamin

AU - Clement, Louise

AU - Kay, Edward

AU - Courtney, Cheryl

AU - Gallagher, Madalena

AU - Murphy, Claire

AU - Thompson, Lindsay

AU - Beall, Sarah

AU - Hassan, Sharma

AU - Gracie, Richard

AU - Griffiths, Gareth

AU - Mason, Malcolm

AU - Parker, Chris

AU - Rudd, Robin

AU - Johnson, Patrick

AU - Whelan, Jeremy

AU - Northover, John

AU - Brown, Julia

AU - Aapro, Matti

AU - Stout, Ronald

AU - Midgley, Rachel

AU - Kerr, David J.

AU - Campbell, Harry

AU - Tomlinson, Ian P.

AU - Houlston, Richard S.

PY - 2012/7

Y1 - 2012/7

N2 - We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

AB - We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

UR - http://www.scopus.com/inward/record.url?scp=84863005628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863005628&partnerID=8YFLogxK

U2 - 10.1038/ng.2293

DO - 10.1038/ng.2293

M3 - Article

C2 - 22634755

AN - SCOPUS:84863005628

VL - 44

SP - 770

EP - 776

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 7

ER -