Common variants at 12q15 and 12q24 are associated with infant head circumference

H. Rob Taal, Beate St Pourcain, Elisabeth Thiering, Shikta Das, Dennis O. Mook-Kanamori, Nicole M. Warrington, Marika Kaakinen, Eskil Kreiner-Møller, Jonathan P. Bradfield, Rachel M. Freathy, Frank Geller, Mònica Guxens, Diana L. Cousminer, Marjan Kerkhof, Nicholas J. Timpson, M. Arfan Ikram, Lawrence J. Beilin, Klaus Bønnelykke, Jessica L. Buxton, Pimphen Charoen & 164 others Bo Lund Krogsgaard Chawes, Johan Eriksson, David M. Evans, Albert Hofman, John P. Kemp, Cecilia E. Kim, Norman Klopp, Jari Lahti, Stephen J. Lye, George Mcmahon, Frank D. Mentch, Martina Müller-Nurasyid, Paul F. O'reilly, Inga Prokopenko, Fernando Rivadeneira, Eric A P Steegers, Jordi Sunyer, Carla Tiesler, Hanieh Yaghootkar, Myriam Fornage, Albert V. Smith, Sudha Seshadri, Reinhold Schmidt, Stéphanie Debette, Henri A. Vrooman, Sigurdur Sigurdsson, Stefan Ropele, Laura H. Coker, W. T. Longstreth, Wiro J. Niessen, Anita L. Destefano, Alexa Beiser, Alex P. Zijdenbos, Maksim Struchalin, Clifford R. Jack, Mike A. Nalls, Rhoda Au, Haukur Gudnason, Aad Van Der Lugt, Tamara B. Harris, William M. Meeks, Meike W. Vernooij, Mark A. Van Buchem, Diane Catellier, Vilmundur Gudnason, B. Gwen Windham, Philip A. Wolf, Cornelia M. Van Duijn, Thomas H. Mosley, Helena Schmidt, Lenore J. Launer, Monique M B Breteler, Wei Ang, Toos Van Beijsterveldt, Nienke Bergen, Kelly Benke, Diane Berry, Lachlan Coin, Paul Elliott, Tim Frayling, Romy Gaillard, Maria Groen-Blokhuis, Dexter Hadley, Jouke Jan Hottenga, Ville Huikari, Elina Hypponen, Matthew Kowgier, Debbie A. Lawlor, Alex Lewin, Cecilia Lindgren, Julie Marsh, Christel Middeldorp, Iona Millwood, Michel Nivard, Lyle J. Palmer, Alina Rodriguez, Sylvain Sebert, Ulla Sovio, Marie Standl, David P. Strachan, H. Rob Taal, Andre G. Uitterlinden, Beatriz Valcárcel, Scott White, Gonneke Willemsen, Dorret I. Boomsma, Xavier Estivill, Struan F A Grant, Andrew T. Hattersley, Joachim Heinrich, Vincent W V Jaddoe, Marjo Riitta Jarvelin, Mark I. Mccarthy, Craig E. Pennell, Chris Power, Elisabeth Widen, Alexandra I F Blakemore, Rosetta M. Chiavacci, Bjarke Feenstra, Julio Fernandez-Banet, Anna Liisa Hartikainen, Albert J. Van Der Heijden, Carmen Iñiguez, Mark Lathrop, Wendy L. Mcardle, Anne Mølgaard, John P. Newnham, Aarno Palotie, Annneli Pouta, Susan M. Ring, H. Erich Wichmann, Nadja Hawwa Vissing, Charles DeCarli, Gerard H. Koppelman, Mads Melbye, Hans Bisgaard, Hakon Hakonarson, George Davey Smith, Vincent W V Jaddoe, Linda S. Adair, Mustafa Atalay, Oliver S P Davis, Claudia Flexeder, Liang Kee Goh, Claire M A Haworth, Johannes Hedebrand, Anke Hinney, Joel N. Hirschhorn, John W. Holloway, Claus Holst, Momoko Horikoshi, Tuomas O. Kilpeläinen, Mirna Kirin, Hanna Maaria Lakka, Leslie A. Lange, Terho Lehtimäki, Virpi Lindi, Reedik Maggi, Jeffrey C. Murray, Ellen Aagaard Nohr, Ioanna Ntalla, Emily Oken, Kalliope Panoutsopoulou, Jennifer Pararajasingham, Rany M. Salem, Niina Siitonen, H. Rob Taal, Yik Ying Teo, Eleftheria Zeggini, Cyrus Cooper, Matthew Gillman, Berthold Hocher, Timo A. Lakka, Karen L. Mohlke, George V. Dedoussis, Ken K. Ong, Ewan R. Pearson, Thomas S. Price, Olli T. Raitakari, Seang Mei Saw, Andre Scherag, Olli Simell, Thorkild I A Sørensen, James F. Wilson

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.

Original languageEnglish (US)
Pages (from-to)532-538
Number of pages7
JournalNature Genetics
Volume44
Issue number5
DOIs
StatePublished - May 2012

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Head
Chromosomes
Genome-Wide Association Study
Neurodegenerative Diseases
Single Nucleotide Polymorphism
Parkinson Disease
Meta-Analysis
Parturition
Genome
Pregnancy
Brain
Growth

ASJC Scopus subject areas

  • Genetics

Cite this

Rob Taal, H., St Pourcain, B., Thiering, E., Das, S., Mook-Kanamori, D. O., Warrington, N. M., ... Wilson, J. F. (2012). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44(5), 532-538. https://doi.org/10.1038/ng.2238

Common variants at 12q15 and 12q24 are associated with infant head circumference. / Rob Taal, H.; St Pourcain, Beate; Thiering, Elisabeth; Das, Shikta; Mook-Kanamori, Dennis O.; Warrington, Nicole M.; Kaakinen, Marika; Kreiner-Møller, Eskil; Bradfield, Jonathan P.; Freathy, Rachel M.; Geller, Frank; Guxens, Mònica; Cousminer, Diana L.; Kerkhof, Marjan; Timpson, Nicholas J.; Ikram, M. Arfan; Beilin, Lawrence J.; Bønnelykke, Klaus; Buxton, Jessica L.; Charoen, Pimphen; Chawes, Bo Lund Krogsgaard; Eriksson, Johan; Evans, David M.; Hofman, Albert; Kemp, John P.; Kim, Cecilia E.; Klopp, Norman; Lahti, Jari; Lye, Stephen J.; Mcmahon, George; Mentch, Frank D.; Müller-Nurasyid, Martina; O'reilly, Paul F.; Prokopenko, Inga; Rivadeneira, Fernando; Steegers, Eric A P; Sunyer, Jordi; Tiesler, Carla; Yaghootkar, Hanieh; Fornage, Myriam; Smith, Albert V.; Seshadri, Sudha; Schmidt, Reinhold; Debette, Stéphanie; Vrooman, Henri A.; Sigurdsson, Sigurdur; Ropele, Stefan; Coker, Laura H.; Longstreth, W. T.; Niessen, Wiro J.; Destefano, Anita L.; Beiser, Alexa; Zijdenbos, Alex P.; Struchalin, Maksim; Jack, Clifford R.; Nalls, Mike A.; Au, Rhoda; Gudnason, Haukur; Van Der Lugt, Aad; Harris, Tamara B.; Meeks, William M.; Vernooij, Meike W.; Van Buchem, Mark A.; Catellier, Diane; Gudnason, Vilmundur; Windham, B. Gwen; Wolf, Philip A.; Van Duijn, Cornelia M.; Mosley, Thomas H.; Schmidt, Helena; Launer, Lenore J.; Breteler, Monique M B; Ang, Wei; Van Beijsterveldt, Toos; Bergen, Nienke; Benke, Kelly; Berry, Diane; Coin, Lachlan; Elliott, Paul; Frayling, Tim; Gaillard, Romy; Groen-Blokhuis, Maria; Hadley, Dexter; Hottenga, Jouke Jan; Huikari, Ville; Hypponen, Elina; Kowgier, Matthew; Lawlor, Debbie A.; Lewin, Alex; Lindgren, Cecilia; Marsh, Julie; Middeldorp, Christel; Millwood, Iona; Nivard, Michel; Palmer, Lyle J.; Rodriguez, Alina; Sebert, Sylvain; Sovio, Ulla; Standl, Marie; Strachan, David P.; Rob Taal, H.; Uitterlinden, Andre G.; Valcárcel, Beatriz; White, Scott; Willemsen, Gonneke; Boomsma, Dorret I.; Estivill, Xavier; Grant, Struan F A; Hattersley, Andrew T.; Heinrich, Joachim; Jaddoe, Vincent W V; Jarvelin, Marjo Riitta; Mccarthy, Mark I.; Pennell, Craig E.; Power, Chris; Widen, Elisabeth; Blakemore, Alexandra I F; Chiavacci, Rosetta M.; Feenstra, Bjarke; Fernandez-Banet, Julio; Hartikainen, Anna Liisa; Van Der Heijden, Albert J.; Iñiguez, Carmen; Lathrop, Mark; Mcardle, Wendy L.; Mølgaard, Anne; Newnham, John P.; Palotie, Aarno; Pouta, Annneli; Ring, Susan M.; Wichmann, H. Erich; Vissing, Nadja Hawwa; DeCarli, Charles; Koppelman, Gerard H.; Melbye, Mads; Bisgaard, Hans; Hakonarson, Hakon; Smith, George Davey; Jaddoe, Vincent W V; Adair, Linda S.; Atalay, Mustafa; Davis, Oliver S P; Flexeder, Claudia; Goh, Liang Kee; Haworth, Claire M A; Hedebrand, Johannes; Hinney, Anke; Hirschhorn, Joel N.; Holloway, John W.; Holst, Claus; Horikoshi, Momoko; Kilpeläinen, Tuomas O.; Kirin, Mirna; Lakka, Hanna Maaria; Lange, Leslie A.; Lehtimäki, Terho; Lindi, Virpi; Maggi, Reedik; Murray, Jeffrey C.; Nohr, Ellen Aagaard; Ntalla, Ioanna; Oken, Emily; Panoutsopoulou, Kalliope; Pararajasingham, Jennifer; Salem, Rany M.; Siitonen, Niina; Rob Taal, H.; Teo, Yik Ying; Zeggini, Eleftheria; Cooper, Cyrus; Gillman, Matthew; Hocher, Berthold; Lakka, Timo A.; Mohlke, Karen L.; Dedoussis, George V.; Ong, Ken K.; Pearson, Ewan R.; Price, Thomas S.; Raitakari, Olli T.; Saw, Seang Mei; Scherag, Andre; Simell, Olli; Sørensen, Thorkild I A; Wilson, James F.

In: Nature Genetics, Vol. 44, No. 5, 05.2012, p. 532-538.

Research output: Contribution to journalArticle

Rob Taal, H, St Pourcain, B, Thiering, E, Das, S, Mook-Kanamori, DO, Warrington, NM, Kaakinen, M, Kreiner-Møller, E, Bradfield, JP, Freathy, RM, Geller, F, Guxens, M, Cousminer, DL, Kerkhof, M, Timpson, NJ, Ikram, MA, Beilin, LJ, Bønnelykke, K, Buxton, JL, Charoen, P, Chawes, BLK, Eriksson, J, Evans, DM, Hofman, A, Kemp, JP, Kim, CE, Klopp, N, Lahti, J, Lye, SJ, Mcmahon, G, Mentch, FD, Müller-Nurasyid, M, O'reilly, PF, Prokopenko, I, Rivadeneira, F, Steegers, EAP, Sunyer, J, Tiesler, C, Yaghootkar, H, Fornage, M, Smith, AV, Seshadri, S, Schmidt, R, Debette, S, Vrooman, HA, Sigurdsson, S, Ropele, S, Coker, LH, Longstreth, WT, Niessen, WJ, Destefano, AL, Beiser, A, Zijdenbos, AP, Struchalin, M, Jack, CR, Nalls, MA, Au, R, Gudnason, H, Van Der Lugt, A, Harris, TB, Meeks, WM, Vernooij, MW, Van Buchem, MA, Catellier, D, Gudnason, V, Windham, BG, Wolf, PA, Van Duijn, CM, Mosley, TH, Schmidt, H, Launer, LJ, Breteler, MMB, Ang, W, Van Beijsterveldt, T, Bergen, N, Benke, K, Berry, D, Coin, L, Elliott, P, Frayling, T, Gaillard, R, Groen-Blokhuis, M, Hadley, D, Hottenga, JJ, Huikari, V, Hypponen, E, Kowgier, M, Lawlor, DA, Lewin, A, Lindgren, C, Marsh, J, Middeldorp, C, Millwood, I, Nivard, M, Palmer, LJ, Rodriguez, A, Sebert, S, Sovio, U, Standl, M, Strachan, DP, Rob Taal, H, Uitterlinden, AG, Valcárcel, B, White, S, Willemsen, G, Boomsma, DI, Estivill, X, Grant, SFA, Hattersley, AT, Heinrich, J, Jaddoe, VWV, Jarvelin, MR, Mccarthy, MI, Pennell, CE, Power, C, Widen, E, Blakemore, AIF, Chiavacci, RM, Feenstra, B, Fernandez-Banet, J, Hartikainen, AL, Van Der Heijden, AJ, Iñiguez, C, Lathrop, M, Mcardle, WL, Mølgaard, A, Newnham, JP, Palotie, A, Pouta, A, Ring, SM, Wichmann, HE, Vissing, NH, DeCarli, C, Koppelman, GH, Melbye, M, Bisgaard, H, Hakonarson, H, Smith, GD, Jaddoe, VWV, Adair, LS, Atalay, M, Davis, OSP, Flexeder, C, Goh, LK, Haworth, CMA, Hedebrand, J, Hinney, A, Hirschhorn, JN, Holloway, JW, Holst, C, Horikoshi, M, Kilpeläinen, TO, Kirin, M, Lakka, HM, Lange, LA, Lehtimäki, T, Lindi, V, Maggi, R, Murray, JC, Nohr, EA, Ntalla, I, Oken, E, Panoutsopoulou, K, Pararajasingham, J, Salem, RM, Siitonen, N, Rob Taal, H, Teo, YY, Zeggini, E, Cooper, C, Gillman, M, Hocher, B, Lakka, TA, Mohlke, KL, Dedoussis, GV, Ong, KK, Pearson, ER, Price, TS, Raitakari, OT, Saw, SM, Scherag, A, Simell, O, Sørensen, TIA & Wilson, JF 2012, 'Common variants at 12q15 and 12q24 are associated with infant head circumference', Nature Genetics, vol. 44, no. 5, pp. 532-538. https://doi.org/10.1038/ng.2238
Rob Taal H, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM et al. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics. 2012 May;44(5):532-538. https://doi.org/10.1038/ng.2238
Rob Taal, H. ; St Pourcain, Beate ; Thiering, Elisabeth ; Das, Shikta ; Mook-Kanamori, Dennis O. ; Warrington, Nicole M. ; Kaakinen, Marika ; Kreiner-Møller, Eskil ; Bradfield, Jonathan P. ; Freathy, Rachel M. ; Geller, Frank ; Guxens, Mònica ; Cousminer, Diana L. ; Kerkhof, Marjan ; Timpson, Nicholas J. ; Ikram, M. Arfan ; Beilin, Lawrence J. ; Bønnelykke, Klaus ; Buxton, Jessica L. ; Charoen, Pimphen ; Chawes, Bo Lund Krogsgaard ; Eriksson, Johan ; Evans, David M. ; Hofman, Albert ; Kemp, John P. ; Kim, Cecilia E. ; Klopp, Norman ; Lahti, Jari ; Lye, Stephen J. ; Mcmahon, George ; Mentch, Frank D. ; Müller-Nurasyid, Martina ; O'reilly, Paul F. ; Prokopenko, Inga ; Rivadeneira, Fernando ; Steegers, Eric A P ; Sunyer, Jordi ; Tiesler, Carla ; Yaghootkar, Hanieh ; Fornage, Myriam ; Smith, Albert V. ; Seshadri, Sudha ; Schmidt, Reinhold ; Debette, Stéphanie ; Vrooman, Henri A. ; Sigurdsson, Sigurdur ; Ropele, Stefan ; Coker, Laura H. ; Longstreth, W. T. ; Niessen, Wiro J. ; Destefano, Anita L. ; Beiser, Alexa ; Zijdenbos, Alex P. ; Struchalin, Maksim ; Jack, Clifford R. ; Nalls, Mike A. ; Au, Rhoda ; Gudnason, Haukur ; Van Der Lugt, Aad ; Harris, Tamara B. ; Meeks, William M. ; Vernooij, Meike W. ; Van Buchem, Mark A. ; Catellier, Diane ; Gudnason, Vilmundur ; Windham, B. Gwen ; Wolf, Philip A. ; Van Duijn, Cornelia M. ; Mosley, Thomas H. ; Schmidt, Helena ; Launer, Lenore J. ; Breteler, Monique M B ; Ang, Wei ; Van Beijsterveldt, Toos ; Bergen, Nienke ; Benke, Kelly ; Berry, Diane ; Coin, Lachlan ; Elliott, Paul ; Frayling, Tim ; Gaillard, Romy ; Groen-Blokhuis, Maria ; Hadley, Dexter ; Hottenga, Jouke Jan ; Huikari, Ville ; Hypponen, Elina ; Kowgier, Matthew ; Lawlor, Debbie A. ; Lewin, Alex ; Lindgren, Cecilia ; Marsh, Julie ; Middeldorp, Christel ; Millwood, Iona ; Nivard, Michel ; Palmer, Lyle J. ; Rodriguez, Alina ; Sebert, Sylvain ; Sovio, Ulla ; Standl, Marie ; Strachan, David P. ; Rob Taal, H. ; Uitterlinden, Andre G. ; Valcárcel, Beatriz ; White, Scott ; Willemsen, Gonneke ; Boomsma, Dorret I. ; Estivill, Xavier ; Grant, Struan F A ; Hattersley, Andrew T. ; Heinrich, Joachim ; Jaddoe, Vincent W V ; Jarvelin, Marjo Riitta ; Mccarthy, Mark I. ; Pennell, Craig E. ; Power, Chris ; Widen, Elisabeth ; Blakemore, Alexandra I F ; Chiavacci, Rosetta M. ; Feenstra, Bjarke ; Fernandez-Banet, Julio ; Hartikainen, Anna Liisa ; Van Der Heijden, Albert J. ; Iñiguez, Carmen ; Lathrop, Mark ; Mcardle, Wendy L. ; Mølgaard, Anne ; Newnham, John P. ; Palotie, Aarno ; Pouta, Annneli ; Ring, Susan M. ; Wichmann, H. Erich ; Vissing, Nadja Hawwa ; DeCarli, Charles ; Koppelman, Gerard H. ; Melbye, Mads ; Bisgaard, Hans ; Hakonarson, Hakon ; Smith, George Davey ; Jaddoe, Vincent W V ; Adair, Linda S. ; Atalay, Mustafa ; Davis, Oliver S P ; Flexeder, Claudia ; Goh, Liang Kee ; Haworth, Claire M A ; Hedebrand, Johannes ; Hinney, Anke ; Hirschhorn, Joel N. ; Holloway, John W. ; Holst, Claus ; Horikoshi, Momoko ; Kilpeläinen, Tuomas O. ; Kirin, Mirna ; Lakka, Hanna Maaria ; Lange, Leslie A. ; Lehtimäki, Terho ; Lindi, Virpi ; Maggi, Reedik ; Murray, Jeffrey C. ; Nohr, Ellen Aagaard ; Ntalla, Ioanna ; Oken, Emily ; Panoutsopoulou, Kalliope ; Pararajasingham, Jennifer ; Salem, Rany M. ; Siitonen, Niina ; Rob Taal, H. ; Teo, Yik Ying ; Zeggini, Eleftheria ; Cooper, Cyrus ; Gillman, Matthew ; Hocher, Berthold ; Lakka, Timo A. ; Mohlke, Karen L. ; Dedoussis, George V. ; Ong, Ken K. ; Pearson, Ewan R. ; Price, Thomas S. ; Raitakari, Olli T. ; Saw, Seang Mei ; Scherag, Andre ; Simell, Olli ; Sørensen, Thorkild I A ; Wilson, James F. / Common variants at 12q15 and 12q24 are associated with infant head circumference. In: Nature Genetics. 2012 ; Vol. 44, No. 5. pp. 532-538.
@article{a2e1a41282ff49998ba7145e619e1e7f,
title = "Common variants at 12q15 and 12q24 are associated with infant head circumference",
abstract = "To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.",
author = "{Rob Taal}, H. and {St Pourcain}, Beate and Elisabeth Thiering and Shikta Das and Mook-Kanamori, {Dennis O.} and Warrington, {Nicole M.} and Marika Kaakinen and Eskil Kreiner-M{\o}ller and Bradfield, {Jonathan P.} and Freathy, {Rachel M.} and Frank Geller and M{\`o}nica Guxens and Cousminer, {Diana L.} and Marjan Kerkhof and Timpson, {Nicholas J.} and Ikram, {M. Arfan} and Beilin, {Lawrence J.} and Klaus B{\o}nnelykke and Buxton, {Jessica L.} and Pimphen Charoen and Chawes, {Bo Lund Krogsgaard} and Johan Eriksson and Evans, {David M.} and Albert Hofman and Kemp, {John P.} and Kim, {Cecilia E.} and Norman Klopp and Jari Lahti and Lye, {Stephen J.} and George Mcmahon and Mentch, {Frank D.} and Martina M{\"u}ller-Nurasyid and O'reilly, {Paul F.} and Inga Prokopenko and Fernando Rivadeneira and Steegers, {Eric A P} and Jordi Sunyer and Carla Tiesler and Hanieh Yaghootkar and Myriam Fornage and Smith, {Albert V.} and Sudha Seshadri and Reinhold Schmidt and St{\'e}phanie Debette and Vrooman, {Henri A.} and Sigurdur Sigurdsson and Stefan Ropele and Coker, {Laura H.} and Longstreth, {W. T.} and Niessen, {Wiro J.} and Destefano, {Anita L.} and Alexa Beiser and Zijdenbos, {Alex P.} and Maksim Struchalin and Jack, {Clifford R.} and Nalls, {Mike A.} and Rhoda Au and Haukur Gudnason and {Van Der Lugt}, Aad and Harris, {Tamara B.} and Meeks, {William M.} and Vernooij, {Meike W.} and {Van Buchem}, {Mark A.} and Diane Catellier and Vilmundur Gudnason and Windham, {B. Gwen} and Wolf, {Philip A.} and {Van Duijn}, {Cornelia M.} and Mosley, {Thomas H.} and Helena Schmidt and Launer, {Lenore J.} and Breteler, {Monique M B} and Wei Ang and {Van Beijsterveldt}, Toos and Nienke Bergen and Kelly Benke and Diane Berry and Lachlan Coin and Paul Elliott and Tim Frayling and Romy Gaillard and Maria Groen-Blokhuis and Dexter Hadley and Hottenga, {Jouke Jan} and Ville Huikari and Elina Hypponen and Matthew Kowgier and Lawlor, {Debbie A.} and Alex Lewin and Cecilia Lindgren and Julie Marsh and Christel Middeldorp and Iona Millwood and Michel Nivard and Palmer, {Lyle J.} and Alina Rodriguez and Sylvain Sebert and Ulla Sovio and Marie Standl and Strachan, {David P.} and {Rob Taal}, H. and Uitterlinden, {Andre G.} and Beatriz Valc{\'a}rcel and Scott White and Gonneke Willemsen and Boomsma, {Dorret I.} and Xavier Estivill and Grant, {Struan F A} and Hattersley, {Andrew T.} and Joachim Heinrich and Jaddoe, {Vincent W V} and Jarvelin, {Marjo Riitta} and Mccarthy, {Mark I.} and Pennell, {Craig E.} and Chris Power and Elisabeth Widen and Blakemore, {Alexandra I F} and Chiavacci, {Rosetta M.} and Bjarke Feenstra and Julio Fernandez-Banet and Hartikainen, {Anna Liisa} and {Van Der Heijden}, {Albert J.} and Carmen I{\~n}iguez and Mark Lathrop and Mcardle, {Wendy L.} and Anne M{\o}lgaard and Newnham, {John P.} and Aarno Palotie and Annneli Pouta and Ring, {Susan M.} and Wichmann, {H. Erich} and Vissing, {Nadja Hawwa} and Charles DeCarli and Koppelman, {Gerard H.} and Mads Melbye and Hans Bisgaard and Hakon Hakonarson and Smith, {George Davey} and Jaddoe, {Vincent W V} and Adair, {Linda S.} and Mustafa Atalay and Davis, {Oliver S P} and Claudia Flexeder and Goh, {Liang Kee} and Haworth, {Claire M A} and Johannes Hedebrand and Anke Hinney and Hirschhorn, {Joel N.} and Holloway, {John W.} and Claus Holst and Momoko Horikoshi and Kilpel{\"a}inen, {Tuomas O.} and Mirna Kirin and Lakka, {Hanna Maaria} and Lange, {Leslie A.} and Terho Lehtim{\"a}ki and Virpi Lindi and Reedik Maggi and Murray, {Jeffrey C.} and Nohr, {Ellen Aagaard} and Ioanna Ntalla and Emily Oken and Kalliope Panoutsopoulou and Jennifer Pararajasingham and Salem, {Rany M.} and Niina Siitonen and {Rob Taal}, H. and Teo, {Yik Ying} and Eleftheria Zeggini and Cyrus Cooper and Matthew Gillman and Berthold Hocher and Lakka, {Timo A.} and Mohlke, {Karen L.} and Dedoussis, {George V.} and Ong, {Ken K.} and Pearson, {Ewan R.} and Price, {Thomas S.} and Raitakari, {Olli T.} and Saw, {Seang Mei} and Andre Scherag and Olli Simell and S{\o}rensen, {Thorkild I A} and Wilson, {James F.}",
year = "2012",
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doi = "10.1038/ng.2238",
language = "English (US)",
volume = "44",
pages = "532--538",
journal = "Nature Genetics",
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TY - JOUR

T1 - Common variants at 12q15 and 12q24 are associated with infant head circumference

AU - Rob Taal, H.

AU - St Pourcain, Beate

AU - Thiering, Elisabeth

AU - Das, Shikta

AU - Mook-Kanamori, Dennis O.

AU - Warrington, Nicole M.

AU - Kaakinen, Marika

AU - Kreiner-Møller, Eskil

AU - Bradfield, Jonathan P.

AU - Freathy, Rachel M.

AU - Geller, Frank

AU - Guxens, Mònica

AU - Cousminer, Diana L.

AU - Kerkhof, Marjan

AU - Timpson, Nicholas J.

AU - Ikram, M. Arfan

AU - Beilin, Lawrence J.

AU - Bønnelykke, Klaus

AU - Buxton, Jessica L.

AU - Charoen, Pimphen

AU - Chawes, Bo Lund Krogsgaard

AU - Eriksson, Johan

AU - Evans, David M.

AU - Hofman, Albert

AU - Kemp, John P.

AU - Kim, Cecilia E.

AU - Klopp, Norman

AU - Lahti, Jari

AU - Lye, Stephen J.

AU - Mcmahon, George

AU - Mentch, Frank D.

AU - Müller-Nurasyid, Martina

AU - O'reilly, Paul F.

AU - Prokopenko, Inga

AU - Rivadeneira, Fernando

AU - Steegers, Eric A P

AU - Sunyer, Jordi

AU - Tiesler, Carla

AU - Yaghootkar, Hanieh

AU - Fornage, Myriam

AU - Smith, Albert V.

AU - Seshadri, Sudha

AU - Schmidt, Reinhold

AU - Debette, Stéphanie

AU - Vrooman, Henri A.

AU - Sigurdsson, Sigurdur

AU - Ropele, Stefan

AU - Coker, Laura H.

AU - Longstreth, W. T.

AU - Niessen, Wiro J.

AU - Destefano, Anita L.

AU - Beiser, Alexa

AU - Zijdenbos, Alex P.

AU - Struchalin, Maksim

AU - Jack, Clifford R.

AU - Nalls, Mike A.

AU - Au, Rhoda

AU - Gudnason, Haukur

AU - Van Der Lugt, Aad

AU - Harris, Tamara B.

AU - Meeks, William M.

AU - Vernooij, Meike W.

AU - Van Buchem, Mark A.

AU - Catellier, Diane

AU - Gudnason, Vilmundur

AU - Windham, B. Gwen

AU - Wolf, Philip A.

AU - Van Duijn, Cornelia M.

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AU - Wilson, James F.

PY - 2012/5

Y1 - 2012/5

N2 - To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.

AB - To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.

UR - http://www.scopus.com/inward/record.url?scp=84860324077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860324077&partnerID=8YFLogxK

U2 - 10.1038/ng.2238

DO - 10.1038/ng.2238

M3 - Article

VL - 44

SP - 532

EP - 538

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 5

ER -