Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity

Valentina Medici, Stephen A. McClave, Keith R. Miller

Research output: Contribution to journalReview article

Abstract

Obesity is one of the most common chronic conditions in the world. Its management is difficult, partly due to the multiple associated comorbidities including fatty liver, diabetes, hypertension, and hyperlipidemia. As a result, the choice of prescription medications in overweight and obese patients has important implications as some of them can actually worsen the fat accumulation and its associated metabolic complications. Several prescription medications are associated with weight gain with mechanisms that are often poorly understood and under-recognized. Even less data are available on the distribution of fat and lipotoxicity (the organ damage related to fat accumulation). The present review will discuss the drugs associated with weight gain, their mechanism of action, and the magnitude and timing of their effect.

Original languageEnglish (US)
Pages (from-to)2
Number of pages1
JournalCurrent Gastroenterology Reports
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Weight Gain
Fats
Prescriptions
Fatty Liver
Hyperlipidemias
Comorbidity
Obesity
Hypertension
Pharmaceutical Preparations

Keywords

  • Lipotoxicity
  • Medications
  • Obesity
  • Side effects
  • Weight

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity. / Medici, Valentina; McClave, Stephen A.; Miller, Keith R.

In: Current Gastroenterology Reports, Vol. 18, No. 1, 01.01.2016, p. 2.

Research output: Contribution to journalReview article

@article{0459d759128e413b90195f1177c2d347,
title = "Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity",
abstract = "Obesity is one of the most common chronic conditions in the world. Its management is difficult, partly due to the multiple associated comorbidities including fatty liver, diabetes, hypertension, and hyperlipidemia. As a result, the choice of prescription medications in overweight and obese patients has important implications as some of them can actually worsen the fat accumulation and its associated metabolic complications. Several prescription medications are associated with weight gain with mechanisms that are often poorly understood and under-recognized. Even less data are available on the distribution of fat and lipotoxicity (the organ damage related to fat accumulation). The present review will discuss the drugs associated with weight gain, their mechanism of action, and the magnitude and timing of their effect.",
keywords = "Lipotoxicity, Medications, Obesity, Side effects, Weight",
author = "Valentina Medici and McClave, {Stephen A.} and Miller, {Keith R.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/s11894-015-0479-4",
language = "English (US)",
volume = "18",
pages = "2",
journal = "Current Gastroenterology Reports",
issn = "1522-8037",
publisher = "Current Medicine Group",
number = "1",

}

TY - JOUR

T1 - Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity

AU - Medici, Valentina

AU - McClave, Stephen A.

AU - Miller, Keith R.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Obesity is one of the most common chronic conditions in the world. Its management is difficult, partly due to the multiple associated comorbidities including fatty liver, diabetes, hypertension, and hyperlipidemia. As a result, the choice of prescription medications in overweight and obese patients has important implications as some of them can actually worsen the fat accumulation and its associated metabolic complications. Several prescription medications are associated with weight gain with mechanisms that are often poorly understood and under-recognized. Even less data are available on the distribution of fat and lipotoxicity (the organ damage related to fat accumulation). The present review will discuss the drugs associated with weight gain, their mechanism of action, and the magnitude and timing of their effect.

AB - Obesity is one of the most common chronic conditions in the world. Its management is difficult, partly due to the multiple associated comorbidities including fatty liver, diabetes, hypertension, and hyperlipidemia. As a result, the choice of prescription medications in overweight and obese patients has important implications as some of them can actually worsen the fat accumulation and its associated metabolic complications. Several prescription medications are associated with weight gain with mechanisms that are often poorly understood and under-recognized. Even less data are available on the distribution of fat and lipotoxicity (the organ damage related to fat accumulation). The present review will discuss the drugs associated with weight gain, their mechanism of action, and the magnitude and timing of their effect.

KW - Lipotoxicity

KW - Medications

KW - Obesity

KW - Side effects

KW - Weight

UR - http://www.scopus.com/inward/record.url?scp=84989790832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989790832&partnerID=8YFLogxK

U2 - 10.1007/s11894-015-0479-4

DO - 10.1007/s11894-015-0479-4

M3 - Review article

VL - 18

SP - 2

JO - Current Gastroenterology Reports

JF - Current Gastroenterology Reports

SN - 1522-8037

IS - 1

ER -