Abstract
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 × 10-14).
Original language | English (US) |
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Pages (from-to) | 26-28 |
Number of pages | 3 |
Journal | Nature Genetics |
Volume | 40 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2008 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics