Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

Emma Jaeger; Emily Webb; Kimberley Howarth; Luis Carvajal-Carmona; Andrew Rowan; Peter Broderick; Axel Walther; Sarah Spain; Alan Pittman; Zoe Kemp; Kate Sullivan; Karl Heinimann; Steven Lubbe; Enric Domingo; Ella Barclay; Lynn Martin; Maggie Gorman; Ian Chandler; Jayaram Vijayakrishnan; Wendy Wood; Elli Papaemmanuil; Steven Penegar; Mobshra Qureshi; Susan Farrington; Albert Tenesa; Jean Baptiste Cazier; David Kerr; Richard Gray; Julian Peto; Malcolm Dunlop; Harry Campbell; Huw Thomas; Richard Houlston; Ian Tomlinson

doi:10.1038/ng.2007.41

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

Emma Jaeger, Emily Webb, Kimberley Howarth, Luis Carvajal-Carmona, Andrew Rowan, Peter Broderick, Axel Walther, Sarah Spain, Alan Pittman, Zoe Kemp, Kate Sullivan, Karl Heinimann, Steven Lubbe, Enric Domingo, Ella Barclay, Lynn Martin, Maggie Gorman, Ian Chandler, Jayaram Vijayakrishnan, Wendy WoodElli Papaemmanuil, Steven Penegar, Mobshra Qureshi, Susan Farrington, Albert Tenesa, Jean Baptiste Cazier, David Kerr, Richard Gray, Julian Peto, Malcolm Dunlop, Harry Campbell, Huw Thomas, Richard Houlston, Ian Tomlinson

Research output: Contribution to journal › Article

239 Scopus citations

Abstract

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 × 10^-14).

Original language	English (US)
Pages (from-to)	26-28
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	1
DOIs	https://doi.org/10.1038/ng.2007.41
State	Published - Jan 2008
Externally published	Yes

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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Jaeger, E., Webb, E., Howarth, K., Carvajal-Carmona, L., Rowan, A., Broderick, P., Walther, A., Spain, S., Pittman, A., Kemp, Z., Sullivan, K., Heinimann, K., Lubbe, S., Domingo, E., Barclay, E., Martin, L., Gorman, M., Chandler, I., Vijayakrishnan, J., ... Tomlinson, I. (2008). Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nature Genetics, 40(1), 26-28. https://doi.org/10.1038/ng.2007.41

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. / Jaeger, Emma; Webb, Emily; Howarth, Kimberley; Carvajal-Carmona, Luis; Rowan, Andrew; Broderick, Peter; Walther, Axel; Spain, Sarah; Pittman, Alan; Kemp, Zoe; Sullivan, Kate; Heinimann, Karl; Lubbe, Steven; Domingo, Enric; Barclay, Ella; Martin, Lynn; Gorman, Maggie; Chandler, Ian; Vijayakrishnan, Jayaram; Wood, Wendy; Papaemmanuil, Elli; Penegar, Steven; Qureshi, Mobshra; Farrington, Susan; Tenesa, Albert; Cazier, Jean Baptiste; Kerr, David; Gray, Richard; Peto, Julian; Dunlop, Malcolm; Campbell, Harry; Thomas, Huw; Houlston, Richard; Tomlinson, Ian.

In: Nature Genetics, Vol. 40, No. 1, 01.2008, p. 26-28.

Research output: Contribution to journal › Article

Jaeger, E, Webb, E, Howarth, K, Carvajal-Carmona, L, Rowan, A, Broderick, P, Walther, A, Spain, S, Pittman, A, Kemp, Z, Sullivan, K, Heinimann, K, Lubbe, S, Domingo, E, Barclay, E, Martin, L, Gorman, M, Chandler, I, Vijayakrishnan, J, Wood, W, Papaemmanuil, E, Penegar, S, Qureshi, M, Farrington, S, Tenesa, A, Cazier, JB, Kerr, D, Gray, R, Peto, J, Dunlop, M, Campbell, H, Thomas, H, Houlston, R & Tomlinson, I 2008, 'Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk', Nature Genetics, vol. 40, no. 1, pp. 26-28. https://doi.org/10.1038/ng.2007.41

Jaeger, Emma ; Webb, Emily ; Howarth, Kimberley ; Carvajal-Carmona, Luis ; Rowan, Andrew ; Broderick, Peter ; Walther, Axel ; Spain, Sarah ; Pittman, Alan ; Kemp, Zoe ; Sullivan, Kate ; Heinimann, Karl ; Lubbe, Steven ; Domingo, Enric ; Barclay, Ella ; Martin, Lynn ; Gorman, Maggie ; Chandler, Ian ; Vijayakrishnan, Jayaram ; Wood, Wendy ; Papaemmanuil, Elli ; Penegar, Steven ; Qureshi, Mobshra ; Farrington, Susan ; Tenesa, Albert ; Cazier, Jean Baptiste ; Kerr, David ; Gray, Richard ; Peto, Julian ; Dunlop, Malcolm ; Campbell, Harry ; Thomas, Huw ; Houlston, Richard ; Tomlinson, Ian. / Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. In: Nature Genetics. 2008 ; Vol. 40, No. 1. pp. 26-28.

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abstract = "We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 × 10-14).",

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AU - Rowan, Andrew

AU - Broderick, Peter

AU - Walther, Axel

AU - Spain, Sarah

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AU - Wood, Wendy

AU - Papaemmanuil, Elli

AU - Penegar, Steven

AU - Qureshi, Mobshra

AU - Farrington, Susan

AU - Tenesa, Albert

AU - Cazier, Jean Baptiste

AU - Kerr, David

AU - Gray, Richard

AU - Peto, Julian

AU - Dunlop, Malcolm

AU - Campbell, Harry

AU - Thomas, Huw

AU - Houlston, Richard

AU - Tomlinson, Ian

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