Abstract
OBJECTIVE: To determine the relationship between two common apoA-IV variants (Thr347→Ser; Gln360→His), and body mass index (BMI) and percentage body fat. DESIGN: Cross-sectional study. SUBJECTS: Eight-hundred and forty-eight subjects screened for participation in ongoing clinical studies. MEASUREMENTS: ApoA-IV genotype, body mass index, waist-to-hip ratio and percentage body fat by bioelectric impedance. RESULTS: Participants had an average age of 41 ± 12 y and an average BMI of 28.2 ± 5.5 kg/m2. Individuals homozygous for the Ser347 allele had higher BMI (32.3 ± 6.6 vs 28.6 ± 5.3 kg/m2; P < 0.01) and percentage body fat (36.9 ± 7.8 vs 31.0 ± 9.6%; P < 0.05) compared with individuals homozygous for Thr347. In contrast, the presence of at least one copy of the His360 allele was associated with lower BMI (27.2 ± 5.0 vs 28.4 ± 5.6 kg/m2; P < 0.05) and percentage body fat (28.6 ± 8.2 vs 30.7 ± 9.1%; P < 0.05). The genotype effects persisted after normalization of the data for the potential confounding effects of gender, age and race. When grouped by BMI percentile, the frequency of the Ser347/Ser347 genotype increased while the frequency of the His360 allele decreased with increasing BMI. CONCLUSIONS: These data suggest a role for apoA-IV in fat storage or mobilization and that genetic variations in the apoA-IV gene may play a role in the development of obesity.
Original language | English (US) |
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Pages (from-to) | 945-953 |
Number of pages | 9 |
Journal | International Journal of Obesity |
Volume | 24 |
Issue number | 8 |
State | Published - 2000 |
Externally published | Yes |
Keywords
- ApoA-IV
- Gene polymorphisms
- Genetics
- Obesity
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Public Health, Environmental and Occupational Health
- Endocrinology
- Food Science
- Endocrinology, Diabetes and Metabolism