Common apolipoprotein A-IV variants are associated with differences in body mass index levels and percentage body fat

M. Lefevre, J. C. Lovejoy, S. M. DeFelice, J. W. Keener, G. A. Bray, D. H. Ryan, D. H. Hwang, F. L. Greenway

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


OBJECTIVE: To determine the relationship between two common apoA-IV variants (Thr347→Ser; Gln360→His), and body mass index (BMI) and percentage body fat. DESIGN: Cross-sectional study. SUBJECTS: Eight-hundred and forty-eight subjects screened for participation in ongoing clinical studies. MEASUREMENTS: ApoA-IV genotype, body mass index, waist-to-hip ratio and percentage body fat by bioelectric impedance. RESULTS: Participants had an average age of 41 ± 12 y and an average BMI of 28.2 ± 5.5 kg/m2. Individuals homozygous for the Ser347 allele had higher BMI (32.3 ± 6.6 vs 28.6 ± 5.3 kg/m2; P < 0.01) and percentage body fat (36.9 ± 7.8 vs 31.0 ± 9.6%; P < 0.05) compared with individuals homozygous for Thr347. In contrast, the presence of at least one copy of the His360 allele was associated with lower BMI (27.2 ± 5.0 vs 28.4 ± 5.6 kg/m2; P < 0.05) and percentage body fat (28.6 ± 8.2 vs 30.7 ± 9.1%; P < 0.05). The genotype effects persisted after normalization of the data for the potential confounding effects of gender, age and race. When grouped by BMI percentile, the frequency of the Ser347/Ser347 genotype increased while the frequency of the His360 allele decreased with increasing BMI. CONCLUSIONS: These data suggest a role for apoA-IV in fat storage or mobilization and that genetic variations in the apoA-IV gene may play a role in the development of obesity.

Original languageEnglish (US)
Pages (from-to)945-953
Number of pages9
JournalInternational Journal of Obesity
Issue number8
StatePublished - 2000
Externally publishedYes


  • ApoA-IV
  • Gene polymorphisms
  • Genetics
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism


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