Comment on Local impermeant anions establish the neuronal chloride concentration

Juha Voipio, Walter F. Boron, Stephen W. Jones, Ulrich Hopfer, John A Payne, Kai Kaila

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Glykys et al. (Reports, 7 February 2014, p. 670) conclude that, rather than ion transporters, "local impermeant anions establish the neuronal chloride concentration" and thereby determine "the magnitude and direction of GABAAR currents at individual synapses." If this were possible, perpetual ion-motion machines could be constructed. The authors' conclusions conflict with basic thermodynamic principles. Copyright

Original languageEnglish (US)
Pages (from-to)1130B
JournalScience
Issue number6201
DOIs
StatePublished - Sep 5 2014

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Anions
Chlorides
Ions
Thermodynamics
Synapses
Direction compound

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Comment on Local impermeant anions establish the neuronal chloride concentration. / Voipio, Juha; Boron, Walter F.; Jones, Stephen W.; Hopfer, Ulrich; Payne, John A; Kaila, Kai.

In: Science, No. 6201, 05.09.2014, p. 1130B.

Research output: Contribution to journalArticle

Voipio, Juha ; Boron, Walter F. ; Jones, Stephen W. ; Hopfer, Ulrich ; Payne, John A ; Kaila, Kai. / Comment on Local impermeant anions establish the neuronal chloride concentration. In: Science. 2014 ; No. 6201. pp. 1130B.
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