Combined keratectomy, strontium-90 irradiation and permanent bulbar conjunctival grafts for corneolimbal squamous cell carcinomas in horses (1990-2002): 38 Horses

C. E. Plummer, S. Smith, S. E. Andrew, Mary Utter, K. N. Gelatt, D. E. Brooks, M. E. Kallberg, F. J. Ollivier

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objective: The purpose of this study was to evaluate the effectiveness of postoperative beta-irradiation with strontium-90 as an adjunctive treatment to superficial keratectomy and permanent bulbar conjunctival graft for removal of equine corneolimbal squamous cell carcinoma (SCC), in decreasing recurrence rate. Study: The retrospective case study included 38 horses diagnosed and treated for SCC of the eye that involved the limbus and/or cornea. The patients were treated between 1990 and 2002, with strontium-90 irradiation immediately after corneal and conjunctival graft surgery. Recurrence was defined as the postoperative and postirradiation regrowth of SCC in the same site and globe that was previously treated. Results: The Appaloosa was the most commonly represented breed and horses that had more than one base coat color represented the majority of the cases (53%). The coat colors of white, chestnut/sorrel and gray were the most commonly represented colors of the horses treated. Eight horses (21%) could not be assessed for tumor recurrence due to lack of two or more post-treatment examinations, and another horse was enucleated 6 days postoperatively due to progressive corneal ulceration. Twenty-four horses (63% of the entire study population; 83% of the followed cases) had a mean ± SD of 1754 ± 1319 days without tumor recurrence, ranging from 14 days to 5110 days. Five horses (13% of the entire study population; 17% of the assessed horses) had tumor recurrence at a mean ± SD of 449 ± 339 days with a range of 29 days to 900 days. For the five recurrences, treatment included local excision (n = 1), enucleation (n = 2), and additional strontium-90 therapy (n = 3). Conclusions: The combination of superficial keratectomy, β-irradiation and permanent bulbar conjunctival grafts for limbal, corneal or corneolimbal SCC in horses is effective in at least 83% of the horses. Recurrence occurred in about 17% of the horses. Multiple biannual re-examinations are recommended to observe for tumor recurrence.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalVeterinary Ophthalmology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Fingerprint

Strontium
strontium
squamous cell carcinoma
Horses
Squamous Cell Carcinoma
irradiation
Transplants
horses
Recurrence
neoplasms
Color
color
Neoplasms
Appaloosa
sorrel
Limbus Corneae
cornea
Therapeutics
Castanea
regrowth

Keywords

  • Beta-irradiation
  • Equine
  • Keratectomy
  • Limbal
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Combined keratectomy, strontium-90 irradiation and permanent bulbar conjunctival grafts for corneolimbal squamous cell carcinomas in horses (1990-2002) : 38 Horses. / Plummer, C. E.; Smith, S.; Andrew, S. E.; Utter, Mary; Gelatt, K. N.; Brooks, D. E.; Kallberg, M. E.; Ollivier, F. J.

In: Veterinary Ophthalmology, Vol. 10, No. 1, 01.01.2007, p. 37-42.

Research output: Contribution to journalArticle

Plummer, C. E. ; Smith, S. ; Andrew, S. E. ; Utter, Mary ; Gelatt, K. N. ; Brooks, D. E. ; Kallberg, M. E. ; Ollivier, F. J. / Combined keratectomy, strontium-90 irradiation and permanent bulbar conjunctival grafts for corneolimbal squamous cell carcinomas in horses (1990-2002) : 38 Horses. In: Veterinary Ophthalmology. 2007 ; Vol. 10, No. 1. pp. 37-42.
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abstract = "Objective: The purpose of this study was to evaluate the effectiveness of postoperative beta-irradiation with strontium-90 as an adjunctive treatment to superficial keratectomy and permanent bulbar conjunctival graft for removal of equine corneolimbal squamous cell carcinoma (SCC), in decreasing recurrence rate. Study: The retrospective case study included 38 horses diagnosed and treated for SCC of the eye that involved the limbus and/or cornea. The patients were treated between 1990 and 2002, with strontium-90 irradiation immediately after corneal and conjunctival graft surgery. Recurrence was defined as the postoperative and postirradiation regrowth of SCC in the same site and globe that was previously treated. Results: The Appaloosa was the most commonly represented breed and horses that had more than one base coat color represented the majority of the cases (53{\%}). The coat colors of white, chestnut/sorrel and gray were the most commonly represented colors of the horses treated. Eight horses (21{\%}) could not be assessed for tumor recurrence due to lack of two or more post-treatment examinations, and another horse was enucleated 6 days postoperatively due to progressive corneal ulceration. Twenty-four horses (63{\%} of the entire study population; 83{\%} of the followed cases) had a mean ± SD of 1754 ± 1319 days without tumor recurrence, ranging from 14 days to 5110 days. Five horses (13{\%} of the entire study population; 17{\%} of the assessed horses) had tumor recurrence at a mean ± SD of 449 ± 339 days with a range of 29 days to 900 days. For the five recurrences, treatment included local excision (n = 1), enucleation (n = 2), and additional strontium-90 therapy (n = 3). Conclusions: The combination of superficial keratectomy, β-irradiation and permanent bulbar conjunctival grafts for limbal, corneal or corneolimbal SCC in horses is effective in at least 83{\%} of the horses. Recurrence occurred in about 17{\%} of the horses. Multiple biannual re-examinations are recommended to observe for tumor recurrence.",
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T2 - 38 Horses

AU - Plummer, C. E.

AU - Smith, S.

AU - Andrew, S. E.

AU - Utter, Mary

AU - Gelatt, K. N.

AU - Brooks, D. E.

AU - Kallberg, M. E.

AU - Ollivier, F. J.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Objective: The purpose of this study was to evaluate the effectiveness of postoperative beta-irradiation with strontium-90 as an adjunctive treatment to superficial keratectomy and permanent bulbar conjunctival graft for removal of equine corneolimbal squamous cell carcinoma (SCC), in decreasing recurrence rate. Study: The retrospective case study included 38 horses diagnosed and treated for SCC of the eye that involved the limbus and/or cornea. The patients were treated between 1990 and 2002, with strontium-90 irradiation immediately after corneal and conjunctival graft surgery. Recurrence was defined as the postoperative and postirradiation regrowth of SCC in the same site and globe that was previously treated. Results: The Appaloosa was the most commonly represented breed and horses that had more than one base coat color represented the majority of the cases (53%). The coat colors of white, chestnut/sorrel and gray were the most commonly represented colors of the horses treated. Eight horses (21%) could not be assessed for tumor recurrence due to lack of two or more post-treatment examinations, and another horse was enucleated 6 days postoperatively due to progressive corneal ulceration. Twenty-four horses (63% of the entire study population; 83% of the followed cases) had a mean ± SD of 1754 ± 1319 days without tumor recurrence, ranging from 14 days to 5110 days. Five horses (13% of the entire study population; 17% of the assessed horses) had tumor recurrence at a mean ± SD of 449 ± 339 days with a range of 29 days to 900 days. For the five recurrences, treatment included local excision (n = 1), enucleation (n = 2), and additional strontium-90 therapy (n = 3). Conclusions: The combination of superficial keratectomy, β-irradiation and permanent bulbar conjunctival grafts for limbal, corneal or corneolimbal SCC in horses is effective in at least 83% of the horses. Recurrence occurred in about 17% of the horses. Multiple biannual re-examinations are recommended to observe for tumor recurrence.

AB - Objective: The purpose of this study was to evaluate the effectiveness of postoperative beta-irradiation with strontium-90 as an adjunctive treatment to superficial keratectomy and permanent bulbar conjunctival graft for removal of equine corneolimbal squamous cell carcinoma (SCC), in decreasing recurrence rate. Study: The retrospective case study included 38 horses diagnosed and treated for SCC of the eye that involved the limbus and/or cornea. The patients were treated between 1990 and 2002, with strontium-90 irradiation immediately after corneal and conjunctival graft surgery. Recurrence was defined as the postoperative and postirradiation regrowth of SCC in the same site and globe that was previously treated. Results: The Appaloosa was the most commonly represented breed and horses that had more than one base coat color represented the majority of the cases (53%). The coat colors of white, chestnut/sorrel and gray were the most commonly represented colors of the horses treated. Eight horses (21%) could not be assessed for tumor recurrence due to lack of two or more post-treatment examinations, and another horse was enucleated 6 days postoperatively due to progressive corneal ulceration. Twenty-four horses (63% of the entire study population; 83% of the followed cases) had a mean ± SD of 1754 ± 1319 days without tumor recurrence, ranging from 14 days to 5110 days. Five horses (13% of the entire study population; 17% of the assessed horses) had tumor recurrence at a mean ± SD of 449 ± 339 days with a range of 29 days to 900 days. For the five recurrences, treatment included local excision (n = 1), enucleation (n = 2), and additional strontium-90 therapy (n = 3). Conclusions: The combination of superficial keratectomy, β-irradiation and permanent bulbar conjunctival grafts for limbal, corneal or corneolimbal SCC in horses is effective in at least 83% of the horses. Recurrence occurred in about 17% of the horses. Multiple biannual re-examinations are recommended to observe for tumor recurrence.

KW - Beta-irradiation

KW - Equine

KW - Keratectomy

KW - Limbal

KW - Squamous cell carcinoma

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