Combined junction pore-fiber entrance layer model for capillary permeability

Ruey Tug Tsay, Fitz Roy E Curry, Bing mei Fu, Sheldon Weinbaum

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In Tsay, et. al., (1989) and Weinbaum, et. al., (1992) a new three-dimensional junction-pore-matrix model was developed to examine the combined role of pores formed by small breaks in the intercellular junction strand and matrix structures in the wide parts of the cleft in the regulation of capillary permeability. In this study the junction pore model was extended to examine the effect of a thin fiber layer at the entrance of the cleft or at the endothelial surface. The matrix structure was represented by either an ordered or random array of perpendicular cylindrical fibers in the entrance region of the wide part of the cleft or a porous medium with parallel channels running perpendicular to the lumen front at the endothelial surface. Our results indicated that for frog mesentery capillaries a cleft with large junctional pores of 22×44 nm and gap spacing of 480 nm and an ordered or random fiber matrix layer can fit the measured values for solute permeability for small ions and large solutes of the size close to albumin and the values for the hydraulic conductivities with and without a fiber layer present. However, it cannot also fit the measured values of solute permeability for the intermediate size solutes of 0.5 to 2.0 nm radius. The model was then modified to increase both the size of the junctional pores to 22×150 nm, and gap spacing to 2700 nm as described in preliminary ultrastructural by Adamson and Michel (1992). The combined junctional pore-fiber entrance layer model described the permeability of all solutes larger than .5 nm, but underestimated the permeability to smaller solutes. The model has been used to direct further studies to investigate structure-function correlation in the cleft between adjacent endothelial cells.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD
Place of PublicationNew York, NY, United States
PublisherPubl by ASME
Pages93-101
Number of pages9
Volume231
ISBN (Print)0791811115
StatePublished - 1992
Externally publishedYes
EventWinter Annual Meeting of the American Society of Mechanical Engineers - Anaheim, CA, USA
Duration: Nov 8 1992Nov 13 1992

Other

OtherWinter Annual Meeting of the American Society of Mechanical Engineers
CityAnaheim, CA, USA
Period11/8/9211/13/92

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes
  • Mechanical Engineering

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  • Cite this

    Tsay, R. T., Curry, F. R. E., Fu, B. M., & Weinbaum, S. (1992). Combined junction pore-fiber entrance layer model for capillary permeability. In American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD (Vol. 231, pp. 93-101). Publ by ASME.