An experimental approach to direct integration of atomic force microscopy (AFM) imaging with single molecule optical detection to combine the resolving power of AFM with the chemical identification capabilities of optical techniques is presented. An instrument that combines AFM and scanning confocal optical microscopy in a single multifunctional setup that maximizes the use of commercially available parts is described. The technique's identification capabilities are demonstrated using a model system of dye-labeled beads.
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)