Combined force and photonic probe microscope with single molecule sensitivity

Aleksandr Noy, Thomas R Huser

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

An experimental approach to direct integration of atomic force microscopy (AFM) imaging with single molecule optical detection to combine the resolving power of AFM with the chemical identification capabilities of optical techniques is presented. An instrument that combines AFM and scanning confocal optical microscopy in a single multifunctional setup that maximizes the use of commercially available parts is described. The technique's identification capabilities are demonstrated using a model system of dye-labeled beads.

Original languageEnglish (US)
Pages (from-to)1217-1221
Number of pages5
JournalReview of Scientific Instruments
Volume74
Issue number3 I
DOIs
StatePublished - Mar 2003
Externally publishedYes

Fingerprint

Photonics
Atomic force microscopy
Microscopes
microscopes
atomic force microscopy
photonics
Molecules
probes
sensitivity
molecules
Confocal microscopy
Optical resolving power
beads
Optical microscopy
Identification (control systems)
Dyes
dyes
microscopy
Scanning
Imaging techniques

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)
  • Instrumentation

Cite this

Combined force and photonic probe microscope with single molecule sensitivity. / Noy, Aleksandr; Huser, Thomas R.

In: Review of Scientific Instruments, Vol. 74, No. 3 I, 03.2003, p. 1217-1221.

Research output: Contribution to journalArticle

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