Combined force and photonic probe microscope with single molecule sensitivity

Aleksandr Noy, Thomas R Huser

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


An experimental approach to direct integration of atomic force microscopy (AFM) imaging with single molecule optical detection to combine the resolving power of AFM with the chemical identification capabilities of optical techniques is presented. An instrument that combines AFM and scanning confocal optical microscopy in a single multifunctional setup that maximizes the use of commercially available parts is described. The technique's identification capabilities are demonstrated using a model system of dye-labeled beads.

Original languageEnglish (US)
Pages (from-to)1217-1221
Number of pages5
JournalReview of Scientific Instruments
Issue number3 I
StatePublished - Mar 2003
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)
  • Instrumentation


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