Combined excision and intralesional bevacizumab for sebaceous carcinoma of the eyelid in an Amur tiger (Panthera tigris altaica)

Michele L. Edelmann, Mary Utter, Lin V. Klein, Kathryn L. Wotman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


An 18-year-old zoo-kept female Amur tiger presented with an approximately 5mm diameter lateral canthal eyelid mass in the left eye which grossly appeared red and irregular. The mass was completely excised via lateral canthoplasty. Histopathologic evaluation was consistent with a diagnosis of sebaceous cell carcinoma, which is a potentially aggressive cutaneous neoplasm. The sebaceous carcinoma recurred within 3months and slowly increased in size until a second surgical excision was performed 9months following the first surgery. The second surgical excision was combined with intralesional injection of 10mg of the antiangiogenic drug bevacizumab. Histology confirmed the diagnosis. The tiger was euthanized 16months postoperatively for reasons unrelated to, and without recurrence of, the eyelid neoplasm. At postmortem, no gross periocular or metastatic lesions were noted, and histopathology of the lateral canthus provided no evidence of recurrence. Surgical excision combined with intralesional bevacizumab treatment induced life-long resolution of the sebaceous carcinoma. Bevacizumab treatment may be associated with the regression of periocular angiogenic proliferative conditions, including neoplasia, by inhibiting angiogenesis.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalVeterinary Ophthalmology
Issue number3
StatePublished - May 1 2013
Externally publishedYes


  • Amur tiger
  • Antiangiogenic
  • Bevacizumab
  • Eyelid
  • Sebaceous carcinoma
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • veterinary(all)


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