Abstract
A Maltese (5-years old, castrated male) and a Yorkshire Terrier (8-years old, intact female) were referred to Seoul National University Hospital for Animals with ataxia, circling, depression and anorexia. It was suspected to meningoencephalitis of unknown etiology (MUE) based on neurological signs, magnetic resonance imaging findings, cerebrospinal fluid analysis and canine distemper virus antigen test. Immunosuppressive dose of corticosteroid was initially chosen to treat in two dogs. However, the clinical signs were relapsed and side effects had arisen including polyuria, polydipsia, calcinosis cutis, liver enzyme elevation, weight gain and abdominal distension. Combination therapy of cytosine arabinoside (CA) and prednisolone (PDS) was tried. With this combination, the clinical signs were resolved and the side effects were alleviated. The dose of PDS was tapered to 0.5 mg/kg q48h in one case and the PDS was discontinued in the other case. These cases suggested that combined CA and PDS therapy may be significantly useful for the treatment of MUE uncontrolled by PDS alone.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 462-467 |
| Number of pages | 6 |
| Journal | Journal of Veterinary Clinics |
| Volume | 27 |
| Issue number | 4 |
| State | Published - Dec 14 2010 |
| Externally published | Yes |
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Keywords
- Cytosine arabinoside
- Meningoencephalitis
- MUE
- Prednisolone
ASJC Scopus subject areas
- veterinary(all)
Cite this
Combined cytosine arabinoside and prednisolone therapy for meningoencephalitis of unknown etiology in 2 dogs. / Kim, Tae Ho; Seo, Kyoung Won; Lee, Young Heun; Hwang, Cheol Yong; Lee, Young Won; Youn, Hwa Young.
In: Journal of Veterinary Clinics, Vol. 27, No. 4, 14.12.2010, p. 462-467.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combined cytosine arabinoside and prednisolone therapy for meningoencephalitis of unknown etiology in 2 dogs
AU - Kim, Tae Ho
AU - Seo, Kyoung Won
AU - Lee, Young Heun
AU - Hwang, Cheol Yong
AU - Lee, Young Won
AU - Youn, Hwa Young
PY - 2010/12/14
Y1 - 2010/12/14
N2 - A Maltese (5-years old, castrated male) and a Yorkshire Terrier (8-years old, intact female) were referred to Seoul National University Hospital for Animals with ataxia, circling, depression and anorexia. It was suspected to meningoencephalitis of unknown etiology (MUE) based on neurological signs, magnetic resonance imaging findings, cerebrospinal fluid analysis and canine distemper virus antigen test. Immunosuppressive dose of corticosteroid was initially chosen to treat in two dogs. However, the clinical signs were relapsed and side effects had arisen including polyuria, polydipsia, calcinosis cutis, liver enzyme elevation, weight gain and abdominal distension. Combination therapy of cytosine arabinoside (CA) and prednisolone (PDS) was tried. With this combination, the clinical signs were resolved and the side effects were alleviated. The dose of PDS was tapered to 0.5 mg/kg q48h in one case and the PDS was discontinued in the other case. These cases suggested that combined CA and PDS therapy may be significantly useful for the treatment of MUE uncontrolled by PDS alone.
AB - A Maltese (5-years old, castrated male) and a Yorkshire Terrier (8-years old, intact female) were referred to Seoul National University Hospital for Animals with ataxia, circling, depression and anorexia. It was suspected to meningoencephalitis of unknown etiology (MUE) based on neurological signs, magnetic resonance imaging findings, cerebrospinal fluid analysis and canine distemper virus antigen test. Immunosuppressive dose of corticosteroid was initially chosen to treat in two dogs. However, the clinical signs were relapsed and side effects had arisen including polyuria, polydipsia, calcinosis cutis, liver enzyme elevation, weight gain and abdominal distension. Combination therapy of cytosine arabinoside (CA) and prednisolone (PDS) was tried. With this combination, the clinical signs were resolved and the side effects were alleviated. The dose of PDS was tapered to 0.5 mg/kg q48h in one case and the PDS was discontinued in the other case. These cases suggested that combined CA and PDS therapy may be significantly useful for the treatment of MUE uncontrolled by PDS alone.
KW - Cytosine arabinoside
KW - Meningoencephalitis
KW - MUE
KW - Prednisolone
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UR - http://www.scopus.com/inward/citedby.url?scp=78649945323&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:78649945323
VL - 27
SP - 462
EP - 467
JO - Journal of Veterinary Clinics
JF - Journal of Veterinary Clinics
SN - 1598-298X
IS - 4
ER -