Combinatorial libraries of synthetic structures: Synthesis, screening, and structure determination

Viktor Krchňák, Nikolai F. Sepetov, Petr Kocis, Marcel Patek, Kit Lam, Michal Lebl

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

One of the basic questions for which modern science continues to seek an answer is the nature of intermolecular communication. Many biological effects are triggered by the interaction of a ligand with its signaling counterpart, and many diseases are caused by the malfunction of this signaling mechanism. Once the role of a particular signaling mechanism is recognized, one may deliberately intercede in this process in an attempt to obviate pathological activity. If there is no a priori knowledge of structure activity relationships between ligand and receptor, or one would like to discover a novel structural motif, the only practical approach is to test a multitude of compounds for the desired activity. The success of this random screening approach depends on both the number and the spread of diversity among compounds available for testing.

Original languageEnglish (US)
Title of host publicationCombinatorial Libraries
Subtitle of host publicationSynthesis, Screening and Application Potential
Publisherde Gruyter
Pages27-52
Number of pages26
ISBN (Electronic)9783110808902
ISBN (Print)311014395X, 9783110143959
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Krchňák, V., Sepetov, N. F., Kocis, P., Patek, M., Lam, K., & Lebl, M. (2013). Combinatorial libraries of synthetic structures: Synthesis, screening, and structure determination. In Combinatorial Libraries: Synthesis, Screening and Application Potential (pp. 27-52). de Gruyter. https://doi.org/10.1515/9783110808902.39