A pilot study of triple combination therapy with didanosine (2',3'- dideoxyinosine or ddI), stavudine (2',3'-didehydro-2',3'-dideoxythymidine or d4T) plus hydroxyurea was performed in 19 HIV-1-infected individuals previously treated with nucleoside analogues having a mean CD4 cell count of 226 cells/mm3. Complete data were not available for the entire patient population at the time of this preliminary analysis as patients were still undergoing experimental therapy. There was a rapid decrease in viral load to as many as 2.0 log10 copies/ml less than at baseline accompanied by a modest increase in CD4 cells of 30-35 cells/mm3. The reason for the minimal increase in CD4 cells may have been secondary to a relative decrease in total lymphocyte counts due to hydroxyurea. This triple combination was relatively well tolerated and produced a good antiviral effect.
|Original language||English (US)|
|Number of pages||5|
|State||Published - 1997|
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