Combination therapy with ciclosporine, ketoconazole and 0.1% tacrolimus ointment for fast reduction of perianal fistulae lesions in three military working dogs

Kyoung Won Seo, Jin Ok Ahn, Ye Rin Coh, Chong Woo Park, Ji Sang Chae, Cheol Yong Hwang, Hwa Young Youn

Research output: Contribution to journalArticlepeer-review

Abstract

Three military working dogs (MWDs) were diagnosed with perianal fistulae after a complete physical examination and rectal palpation. The initial treatment protocol was used with short-term oral ciclosporine (CyA) and ketoconazole and 0.1% topical tacrolimus ointment. When lesions were nearly healed, treatment was continued with 0.1% tacrolimus ointment only at a lower frequency. The lesions improved significantly within 2-8 weeks with no noticeable side effects. Complete recovery was determined at weeks 13, 6, and 4 for cases 1, 2, and 3, respectively. This combination protocol was effective at resolving or reducing perianal fistulae (PAF) lesions even communicating with anal sacs in three dogs. The major benefit of this protocol was the rapid reduction of fistulae lesions and this could be helpful to extend the pain-free period. Moreover, this protocol appeared cost-saving as well as time-saving option for PAF dogs.

Original languageEnglish (US)
Pages (from-to)746-750
Number of pages5
JournalJournal of Veterinary Clinics
Volume27
Issue number6
StatePublished - Dec 1 2010
Externally publishedYes

Keywords

  • Canine
  • Ciclosporine
  • Combination therapy
  • Perianal fistulae
  • Tacrolimus

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'Combination therapy with ciclosporine, ketoconazole and 0.1% tacrolimus ointment for fast reduction of perianal fistulae lesions in three military working dogs'. Together they form a unique fingerprint.

Cite this