Combination drug therapy for Alzheimer's disease: What is evidence-based, and what is not?

Glen Xiong, P. Murali Doraiswamy

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Although FDA-approved Alzheimer's disease (AD) treatment strategies (cholinesterase inhibitors and memantine) offer proven benefits, providers recognize unmet needs beyond what is currently available. Consequently there is a significant use of anecdotal yet unproven combinations for treating AD in practice. Based on the best evidence, combination drug therapy is the standard of care for treating other medical conditions such as malignancies, human immunodeficiency virus (HIV), and hypertension. We review recent combination drug therapy studies in AD. To date, the best evidence-based combination strategy is for moderate-to-severe AD, in which the addition of memantine to stable donepezil therapy was found to benefit cognition, behavior, and function. In milder stages of AD, the benefit of combination drug therapy has not been demonstrated. This review highlights the urgent need to systematically test additional rational drug combinations and the need for future trials to enroll adequate sample sizes and utilize relevant and sensitive outcome measures.

Original languageEnglish (US)
Pages (from-to)22-26
Number of pages5
Issue number6
StatePublished - Jun 2005
Externally publishedYes


  • Alzheimer's disease
  • Cholinesterase inhibitor
  • Memantine combination drug therapy
  • Polypharmacy

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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