Coma and apnea in a dog with hydroxyzine toxicosis

John H. Tegzes, Sean D. Smarick, Birgit Puschner

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hydroxyzine is a commonly prescribed H1-receptor antagonist in small animal practice. The most common adverse effect reported after therapeutic dosing is mild sedation; severe reactions resulting in coma have occasionally been reported in children. We present a case of large po hydroxyzine exposure causing in coma and apnea in a dog. Exposure was confirmed with gas chromatography/mass spectrometry analysis of urine. Extensive therapeutic measures to enhance drug elimination and assist ventilation were required for II d. The positive outcome justifies critical care of similarly exposed animals. Veterinarians should be aware of the potential for coma and apnea secondary to hydroxyzine exposure.

Original languageEnglish (US)
Pages (from-to)24-26
Number of pages3
JournalVeterinary and Human Toxicology
Volume44
Issue number1
StatePublished - 2002

Fingerprint

Hydroxyzine
apnea
coma
Apnea
Coma
poisoning
Dogs
dogs
Animals
drug excretion
small animal practice
Histamine H1 Receptors
therapeutics
urinalysis
Veterinarians
sedation
Gas chromatography
Gas Chromatography-Mass Spectrometry
Ventilation
Mass spectrometry

ASJC Scopus subject areas

  • veterinary(all)
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Coma and apnea in a dog with hydroxyzine toxicosis. / Tegzes, John H.; Smarick, Sean D.; Puschner, Birgit.

In: Veterinary and Human Toxicology, Vol. 44, No. 1, 2002, p. 24-26.

Research output: Contribution to journalArticle

Tegzes, John H. ; Smarick, Sean D. ; Puschner, Birgit. / Coma and apnea in a dog with hydroxyzine toxicosis. In: Veterinary and Human Toxicology. 2002 ; Vol. 44, No. 1. pp. 24-26.
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