TY - JOUR
T1 - Colonization resistance
T2 - The deconvolution of a complex trait
AU - Olsan, Erin E.
AU - Byndloss, Mariana X.
AU - Faber, Franziska
AU - Rivera-Chávez, Fabian
AU - Tsolis, Renee M
AU - Baumler, Andreas J
PY - 2017/5/26
Y1 - 2017/5/26
N2 - Carbapenemase-producing Enterobacteriaceae are an emerging threat to hospitals worldwide, and antibiotic exposure is a risk factor for developing fecal carriage that may lead to nosocomial infection. Here, we review how antibiotics reduce colonization resistance against Enterobacteriaceae to pinpoint possible control points for curbing their spread. Recent work identifies host-derived respiratory electron acceptors as a critical resource driving a post-antibiotic expansion of Enterobacteriaceae within the large bowel. By providing a conceptual framework for colonization resistance against Enterobacteriaceae, these mechanistic insights point to the metabolism of epithelial cells as a possible target for intervention strategies.
AB - Carbapenemase-producing Enterobacteriaceae are an emerging threat to hospitals worldwide, and antibiotic exposure is a risk factor for developing fecal carriage that may lead to nosocomial infection. Here, we review how antibiotics reduce colonization resistance against Enterobacteriaceae to pinpoint possible control points for curbing their spread. Recent work identifies host-derived respiratory electron acceptors as a critical resource driving a post-antibiotic expansion of Enterobacteriaceae within the large bowel. By providing a conceptual framework for colonization resistance against Enterobacteriaceae, these mechanistic insights point to the metabolism of epithelial cells as a possible target for intervention strategies.
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U2 - 10.1074/jbc.R116.752295
DO - 10.1074/jbc.R116.752295
M3 - Review article
C2 - 28389556
AN - SCOPUS:85019689704
VL - 292
SP - 8577
EP - 8581
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 21
ER -