Colonization resistance: The deconvolution of a complex trait

Erin E. Olsan, Mariana X. Byndloss, Franziska Faber, Fabian Rivera-Chávez, Renee M Tsolis, Andreas J Baumler

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Carbapenemase-producing Enterobacteriaceae are an emerging threat to hospitals worldwide, and antibiotic exposure is a risk factor for developing fecal carriage that may lead to nosocomial infection. Here, we review how antibiotics reduce colonization resistance against Enterobacteriaceae to pinpoint possible control points for curbing their spread. Recent work identifies host-derived respiratory electron acceptors as a critical resource driving a post-antibiotic expansion of Enterobacteriaceae within the large bowel. By providing a conceptual framework for colonization resistance against Enterobacteriaceae, these mechanistic insights point to the metabolism of epithelial cells as a possible target for intervention strategies.

Original languageEnglish (US)
Pages (from-to)8577-8581
Number of pages5
JournalJournal of Biological Chemistry
Volume292
Issue number21
DOIs
StatePublished - May 26 2017

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Colonization resistance: The deconvolution of a complex trait'. Together they form a unique fingerprint.

  • Cite this