Abstract
Stereologic methods were used to determine the amount of growth of colonic adenomatous polyps. Epithelial surfaces were increased from 12 to 226 times compared with the normal mucosa of origin, including the epithelium of the crypts. The number of cells was increased from 12 to 370 times. The supposed villi of the polyps are in reality branched folia, and the crypts between them are slit-like, permitting flow of ingesta through them. The increase in the number of cells is not primarily dependent on mitotic activity but more on amitotic nuclear fragmentation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 331-342 |
| Number of pages | 12 |
| Journal | Diseases of the Colon and Rectum |
| Volume | 24 |
| Issue number | 5 |
| State | Published - 1981 |
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ASJC Scopus subject areas
- Gastroenterology
Cite this
Colonic adenomas : Stereology and growth mechanisms. / Elias, H.; Hyde, D. M.; Mullens, R. S.; Lambert, F. C.
In: Diseases of the Colon and Rectum, Vol. 24, No. 5, 1981, p. 331-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Colonic adenomas
T2 - Stereology and growth mechanisms
AU - Elias, H.
AU - Hyde, D. M.
AU - Mullens, R. S.
AU - Lambert, F. C.
PY - 1981
Y1 - 1981
N2 - Stereologic methods were used to determine the amount of growth of colonic adenomatous polyps. Epithelial surfaces were increased from 12 to 226 times compared with the normal mucosa of origin, including the epithelium of the crypts. The number of cells was increased from 12 to 370 times. The supposed villi of the polyps are in reality branched folia, and the crypts between them are slit-like, permitting flow of ingesta through them. The increase in the number of cells is not primarily dependent on mitotic activity but more on amitotic nuclear fragmentation.
AB - Stereologic methods were used to determine the amount of growth of colonic adenomatous polyps. Epithelial surfaces were increased from 12 to 226 times compared with the normal mucosa of origin, including the epithelium of the crypts. The number of cells was increased from 12 to 370 times. The supposed villi of the polyps are in reality branched folia, and the crypts between them are slit-like, permitting flow of ingesta through them. The increase in the number of cells is not primarily dependent on mitotic activity but more on amitotic nuclear fragmentation.
UR - http://www.scopus.com/inward/record.url?scp=0019467145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019467145&partnerID=8YFLogxK
M3 - Article
C2 - 7261815
AN - SCOPUS:0019467145
VL - 24
SP - 331
EP - 342
JO - Diseases of the Colon and Rectum
JF - Diseases of the Colon and Rectum
SN - 0012-3706
IS - 5
ER -