Collateral damage: Microbiota-derived metabolites and immune function in the antibiotic era

Christopher A. Lopez, Dawn D. Kingsbury, Eric M. Velazquez, Andreas J Baumler

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Our long-standing evolutionary association with gut-associated microbial communities has given rise to an intimate relationship, which affects many aspects of human health. Recent studies on the mechanisms that link these microbial communities to immune education, nutrition, and protection against pathogens point to microbiota-derived metabolites as key players during these microbe-host interactions. A disruption of gut-associated microbial communities by antibiotic treatment can result in a depletion of microbiota-derived metabolites, thereby enhancing pathogen susceptibility, impairing immune homeostasis, and contributing to the rise of certain chronic inflammatory diseases. Here, we highlight some of the recently elucidated mechanisms that showcase the impacts of microbiota-derived metabolites on human health.

Original languageEnglish (US)
Pages (from-to)156-163
Number of pages8
JournalCell Host and Microbe
Volume16
Issue number2
DOIs
StatePublished - Aug 13 2014

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

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