Collateral damage: Detrimental effect of antibiotics on the development of protective immune memory

Joseph M. Benoun, Jasmine C. Labuda, Stephen J Mcsorley

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Antibiotic intervention is an effective treatment strategy for many bacterial infections and liberates bacterial antigens and stimulatory products that can induce an inflammatory response. Despite the opportunity for bacterial killing to enhance the development of adaptive immunity, patients treated successfully with antibiotics can suffer from reinfection. Studies in mouse models of Salmonella and Chlamydia infection also demonstrate that early antibiotic intervention reduces host protective immunity to subsequent infection. This heightened susceptibility to reinfection correlates with poor development of Th1 and antibody responses in antibiotic-treated mice but can be overcome by delayed antibiotic intervention, thus suggesting a requirement for sustained T cell stimulation for protection. Although the contribution of memory T cell subsets is imperfectly understood in both of these infection models, a protective role for noncirculating memory cells is suggested by recent studies. Together, these data propose a model where antibiotic treatment specifically interrupts tissue-resident memory T cell formation. Greater understanding of the mechanistic basis of this phenomenon might suggest therapeutic interventions to restore a protective memory response in antibiotic-treated patients, thus reducing the incidence of reinfection.

Original languageEnglish (US)
Article numbere01520-16
JournalmBio
Volume7
Issue number6
DOIs
StatePublished - 2016

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Anti-Bacterial Agents
Bacterial Antigens
T-Lymphocytes
Chlamydia Infections
Cytoprotection
Salmonella Infections
T-Lymphocyte Subsets
Adaptive Immunity
Infection
Bacterial Infections
Antibody Formation
Immunity
Therapeutics
Incidence

ASJC Scopus subject areas

  • Microbiology
  • Virology

Cite this

Collateral damage : Detrimental effect of antibiotics on the development of protective immune memory. / Benoun, Joseph M.; Labuda, Jasmine C.; Mcsorley, Stephen J.

In: mBio, Vol. 7, No. 6, e01520-16, 2016.

Research output: Contribution to journalReview article

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