Abstract
Antibodies to both native and denatured type II collagen were measured in the serum of 63 patients with juvenile onset arthritis (JA) and in 67 patients with adult onset rheumatoid arthritis (RA). Levels of antibodies in the 2 groups were compared with antibody levels in 30 healthy adult controls, and in 20 children with nonrheumatic diseases. Antibodies to denatured and native collagen were increased in RA but not in JA. There was no apparent difference between the collagen antibody levels in any of the 3 subgroups of JA, pauciarticular, polyarticular or systemic onset disease. Antibodies to denatured collagen were not type specific, and reacted similarly with type I and type II collagens, but antibodies to native collagen were much more specific, and most reacted more strongly on type II collagen than on type I collagen. Our results, unlike those in previous reports, imply that antibodies to collagen are infrequent in JA and hence cannot be implicated in the pathogenesis of that disease, which is in contrast to adult onset RA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 289-294 |
| Number of pages | 6 |
| Journal | Journal of Rheumatology |
| Volume | 15 |
| Issue number | 2 |
| State | Published - 1988 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Collagen antibodies in juvenile arthritis and adult rheumatoid arthritis : Differences in levels and type-specificity. / Rowley, M. J.; Gershwin, M. Eric; Mackay, I. R.
In: Journal of Rheumatology, Vol. 15, No. 2, 1988, p. 289-294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Collagen antibodies in juvenile arthritis and adult rheumatoid arthritis
T2 - Differences in levels and type-specificity
AU - Rowley, M. J.
AU - Gershwin, M. Eric
AU - Mackay, I. R.
PY - 1988
Y1 - 1988
N2 - Antibodies to both native and denatured type II collagen were measured in the serum of 63 patients with juvenile onset arthritis (JA) and in 67 patients with adult onset rheumatoid arthritis (RA). Levels of antibodies in the 2 groups were compared with antibody levels in 30 healthy adult controls, and in 20 children with nonrheumatic diseases. Antibodies to denatured and native collagen were increased in RA but not in JA. There was no apparent difference between the collagen antibody levels in any of the 3 subgroups of JA, pauciarticular, polyarticular or systemic onset disease. Antibodies to denatured collagen were not type specific, and reacted similarly with type I and type II collagens, but antibodies to native collagen were much more specific, and most reacted more strongly on type II collagen than on type I collagen. Our results, unlike those in previous reports, imply that antibodies to collagen are infrequent in JA and hence cannot be implicated in the pathogenesis of that disease, which is in contrast to adult onset RA.
AB - Antibodies to both native and denatured type II collagen were measured in the serum of 63 patients with juvenile onset arthritis (JA) and in 67 patients with adult onset rheumatoid arthritis (RA). Levels of antibodies in the 2 groups were compared with antibody levels in 30 healthy adult controls, and in 20 children with nonrheumatic diseases. Antibodies to denatured and native collagen were increased in RA but not in JA. There was no apparent difference between the collagen antibody levels in any of the 3 subgroups of JA, pauciarticular, polyarticular or systemic onset disease. Antibodies to denatured collagen were not type specific, and reacted similarly with type I and type II collagens, but antibodies to native collagen were much more specific, and most reacted more strongly on type II collagen than on type I collagen. Our results, unlike those in previous reports, imply that antibodies to collagen are infrequent in JA and hence cannot be implicated in the pathogenesis of that disease, which is in contrast to adult onset RA.
UR - http://www.scopus.com/inward/record.url?scp=0023833872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023833872&partnerID=8YFLogxK
M3 - Article
VL - 15
SP - 289
EP - 294
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 2
ER -