Colchicine Neuropathy or Vitamin B12 Deficiency Neuropathy?

John J. Palopoli, Jack Waxman, Ralph W. Kuncl, Greg Duncan, Danny Watson, Kathy Alderson, Michael A Rogawski, Marilyn Peper

Research output: Contribution to journalLetterpeer-review

11 Scopus citations


To the Editor: Kuncl et al. (June 18 issue)1 argued that colchicine myopathy may be a common disorder among patients who take customary doses of the drug (1.2 mg per day) for gout, and that the disorder is nearly always associated with a mild axonal polyneuropathy. They analyzed 12 cases to determine the primary risk factors but neglected to consider vitamin B12 deficiency as a possible cause of the associated neuropathies. Colchicine can induce the malabsorption of vitamin B12 by means of a dose-related, reversible reduction in the quantity of intrinsic-factor–vitamin B12 receptors in the intestinal mucosa….

Original languageEnglish (US)
Pages (from-to)1290-1291
Number of pages2
JournalNew England Journal of Medicine
Issue number20
StatePublished - Nov 12 1987
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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